TAK-242(Resatorvid)

Chemical Name:

(6R)-6-[[(2-Chloro-4-fluorophenyl)amino]sulfonyl]-1-cyclohexene-1-carboxylic acid ethyl ester

cas:243984-11-4

Biological Activity:TAK-242 (resatorvid), a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4. Cys747 in TLR4 has been identified previously as the binding site of TAK-242. However, the mechanism by which TAK-242 inhibits TLR4 signaling after binding to TLR4 remains unknown. The present study demonstrated, using coimmunoprecipitation, that TAK-242 interferes with protein-protein interactions between TLR4 and its adaptor molecules,

 

 

Shanghai Yingxuan Chempharm . is a custom synthesis & contract manufacturer and supplier in Chinese pharmaceutical and chemical market. We are dedicated to the research, development(R&D), manufacture and marketing pharmaceutical intermediates, APIs and new moleculars. Our main products include Anti-cancer Drugs(Antineoplastics), Antivirals, Plant Extracts, Pharmaceutical Peptides, Antibiotics and Research Standard Samples for Pharmaceutical Studies(Reference Standards). Our Products have been exported to USA, Europe, Japan, South Korea and etc. Quality of our products complies