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ACS Applied Energy Materials

IF: 5.4
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2-Phenylacetamide Isolated from the Seeds of Lepidium apetalum and Its Estrogen-Like Effects In Vitro and In Vivo.

Published:7 September 2018 DOI: 10.3390/molecules23092293 PMID: 30205508
Mengnan Zeng, Meng Li, Miao Li, Beibei Zhang, Benke Li, Li Zhang, Weisheng Feng, Xiaoke Zheng

Abstract

The aim of this study was to investigate the estrogen-like effects of 2-phenylacetamide (PA), which is the main compound isolated from the seeds of Lepidium apetalum Willd (LA). Results showed that LA and PA could promote the proliferation of MCF-7 cells. The mouse uterine weight test showed that, LA and PA could increase the uterus index of immature female mice, and the levels of luteinizing hormone (LH) and estrogen (E2). LA could increase the expression of ERα and ERβ, while PA could increase the expression of ERα, ERβ and GPR30 in the uterus and MCF-7 cells. In addition, co-incubation of the estrogen receptor blocker with LA or PA abolished the inductive effect of the proliferation. PA has estrogenic activities and was the material basis of LA that played the estrogenic effect. LA and PA might be used for the treatment of perimenopause syndrome in a novel application.

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Procduct Name CAS Molecular Formula Supplier Price
2-Phenylacetamide 103-81-1 C8H9NO 423 suppliers $13.00-$2404.59
Diethylstilbestrol 56-53-1 C18H20O2 377 suppliers $21.00-$3326.40
ESTROGEN RECEPTOR-ALPHA, HUMAN 44 suppliers $356.00-$2190.00
HLH 39341-83-8 NULL 21 suppliers $154.00-$996.00
GPR30 9 suppliers $290.70-$588.00
ERβ (1531) 1 suppliers Inquiry
Lepidium apetalum 1 suppliers Inquiry
ERα 1 suppliers Inquiry

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