PREPARATION OF PROCAINE & PROCAINE HCL

Procaine base

CAS: 59-46-1

Appearance: white crystalline powder

Melting point (boiling point): 59 ~ 62 ℃

Molecular formula: c13h2on2o2

Molecular weight: 236.31

Procaine hcl

CAS: 51-05-8

Appearance: white crystal or crystalline powder

Melting point (boiling point): 154 ℃ ~ 157 ℃

Molecular formula: c13h21cln2o2

Molecular weight: 272.77

 

 

 

 

 

In a 250ml three necked flask with stirrer and thermometer, nitrocaine solution with pH of 4.0-4.2 is added. Under full stirring, activated iron powder is added at 25 ℃ in several times. After adding, the reaction temperature rises automatically and maintains 40-45 ℃. The reaction time was 2 hours. After filtration, the filter residue is washed twice with a small amount of water, the washing solution is combined with the filtrate, acidified to pH 5 with dilute hydrochloric acid (10%), and the saturated sodium sulfide solution is added to pH 7.8-8.0 to precipitate the iron salt in the reaction solution. The filtrate is acidified to ph6 with a small amount of dilute hydrochloric acid, and then heated at 50-60 ℃ for 10 minutes with a small amount of activated carbon. The filter residue is washed once with a small amount of water, the washing solution is combined with the filtrate, cooled to below 10 ℃, and alkalized with 20% NaOH until procaine is completely separated (pH 9.5-10.5). Filter, wash twice, press and drain for salt forming(procaine hcl)

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procaine lidocaine benzocaine Dimethocaine fresh stock, Guarantee delivery.

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pmk powder

443998-65-0

2079878-75-2 Ketoclomazone

705-60-2 p2np

288573-56-8

28578-16-7

20320-59-6 liquid / 25547-51-7 powder form

79099-07-3

5451-09-2

Phenacetin 62-44-2 powder /white little crystals two type

 

Dimethocaine

benzocaine

lidocaine

tetracaine hcl

procaine

boric acid flakes/ chunks

N-methlformamide 123-39-7/ NMF

4-Methylpropiophenone 5337-93-9

49851-31-2

1-Phenyl-1-pentanone 1009-14-9

236117-38-7 2-IODO-1-P-TOLYL- PROPAN-1-ONE

1451-82-7 2-bromo-4-methylpropiophenone

CAS 139755-83-2 Sildenafil

CAS 148553-50-8 pregabalin

CAS 171596-29-5 Tadalafil

CAS 16595-80-5 Levamisole HCL

CAS 5086-74-8 Tetramisole HCL

CAS 171596-29-5 Tadalafil

CAS 16595-80-5 Levamisole HCL

CAS 5086-74-8 Tetramisole HCL

 

 Methoxyethylamine

methoxyethylamine is mainly used as a synthetic intermediate and can also be used as a contrast medium intermediate, CAS NO109-85-3, produced by Baolong Chemical

Chinese name 2-methoxyethylamine Foreign name 2-methoxyethylamine fraction C3H9NOCAS109-85-31.   Properties: Colorless transparent liquid.

2. Density (g/mL,20℃) : 0.874

3. Boiling point (ºC, atmospheric pressure) : 93

4. Boiling point (ºC,kPa) : Not determined

5. Refractive index: 1.406

6. Flash point (ºC) : 12

7 solubility: easily soluble in ethanol and diethyl ether main use

Used as a synthetic intermediate.  

The synthetic methods

1. Methyl 2-methoxyacetic acid was dissolved in methanol, refluxed with ammonia, detected by GC until the reaction was complete, frozen, and filtered to obtain the intermediate 2-methoxyacetamide.

2. Dissolved in anhydrous tetrahydrofuran under the protection of nitrogen, borane dimethyl sulfide was slowly dropped in the reflux state, and the reaction was tested by GC.

3, phosphoric acid aqueous solution destruction, concentrated phosphate, ethanol recrystallization, phosphate pure products.

4, sodium hydroxide methanol solution neutralization, distillation of pure 2-methoxyethylamine.

Storage conditions

• Remind to store in a cool and ventilated warehouse.
• 2. It should be stored separately from oxidants and acids, and should not be mixed.
• 3. Equip the appropriate type and quantity of fire fighting equipment.
• 4. The storage area should be equipped with leakage emergency treatment equipment and appropriate holding materials.

PMK/PMK Glycidate/PMK methyl glycidate CAS28578-16-7

AND BMK  CAS20320-59-6

Name	PMK/PMK Glycidate/PMK methyl glycidate
CAS	28578-16-7
Density	1.3±0.1 g/cm3
Boiling Point	312.8±42.0 °C at 760 mmHg
Molecular Formula	C12H12O5
Molecular Weight	236.221
Usage	Mainly used in organic intermediates, anti - rust agent
Storage condition	keep in a cool and dry place
Delivery	1-3days
Sample	Available

 Synonyms:

Ethyl 3-(1,3-benzodioxol-5-yl)-2-methyl-2-oxiranecarboxylate

2-Oxiranecarboxylic acid, 3-(1,3-benzodioxol-5-yl)-2-methyl-, ethyl ester

PMK ethyl glycidate

 

Payment and delivery

Delivery : We have special line transportation, or we can give it to your forwarder Our special line transport is to ensure safe delivery to your designated location, can be free of customs clearance(FedEx/EMS/UPS/DHL/TNT)

Payment: t/t, paypal, alibaba trade assurance,western union,bitcoin…All means are acceptable as long as they are convenient for you(We do not accept L/C and D/P during coronavirus)

Packaging & Shipping

1.Can be customized

2.The existing packaging

1kg     packing ：Packed with aluminium bags with ziplock bags inside.

10kg   paper carton  (Three high : 500mm 、300mm 、400mm)

25kg   barrel （The diameter：350mm  high：510mm）Packed with paper drum with double plastic bags inside.

Place orders

MOQ: 10 gram

Packing: Aluminum foil bag / customized/ barrel

Payment Terms: Western Union / Money Gram / BTC / T/T / L/C

Mode of Transportation: By air or ship

Express: FedEx, UPS, DHL, TNT, EMS

Loading Port: Shanghai, China/ optional

Delivery Lead Time: Within 3 days

Diethyl phenyl malonate

Chinese name: diethyl phenyllevulonate

Diethyl(phenylacetyl)malonate

CAS no. : 20320-59-6

Molecular formula: C15H18O5

Molecular weight: 278.3

EINECS no. : 205-854-1

Mol file :20320-59-6. Mol Diethyl phenyl malonate properties

Boiling point 120 °C(Press: 0.01 Torr)

1.148 + / - 0.06 g/cm3 density (Predicted)

The coefficient of acidity (pKa) 8.76±0.59

 

1.Can be customized

2.The existing packaging

1kg     packing ：Packed with aluminium bags with ziplock bags inside.

10kg   paper carton  (Three high : 500mm 、300mm 、400mm)

25kg   barrel （The diameter：350mm  high：510mm）Packed with paper drum with double plastic bags inside.

Place orders

MOQ: 10 gram

Packing: Aluminum foil bag / customized/ barrel

Payment Terms: Western Union / Money Gram / BTC / T/T / L/C

Mode of Transportation: By air or ship

Express: FedEx, UPS, DHL, TNT, EMS

Loading Port: Shanghai, China/ optional

Delivery Lead Time: Within 3 days

 

Delivery : We have special line transportation, or we can give it to your forwarder Our special line transport is to ensure safe delivery to your designated location, can be free of customs clearance(FedEx/EMS/UPS/DHL/TNT)

Payment: t/t, paypal, alibaba trade assurance,western union,bitcoin…All means are acceptable as long as they are convenient for you(We do not accept L/C and D/P during coronavirus)