Isothiazolinones
Product identifier
- Product name: Isothiazolinones
- CBnumber: CB4132565
- CAS: 26172-55-4
- EINECS Number: 247-500-7
- Synonyms: CMIT,Isothiazolinones
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 3, Dermal
Skin corrosion, Sub-category 1B
Skin sensitization, Category 1
Serious eye damage, Category 1
Specific target organ toxicity – single exposure, Category 3
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Label elements
Pictogram(s)
-
Signal word
Danger
H301+H311 Toxic if swallowed or in contact with skin
H314 Causes severe skin burns and eye damage
H317 May cause an allergic skin reaction
H318 Causes serious eye damage
H335 May cause respiratory irritation
H400 Very toxic to aquatic life
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P333+P317 If skin irritation or rash occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P317 Get medical help.
P319 Get medical help if you feel unwell.
P391 Collect spillage.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: Isothiazolinones
- Synonyms: CMIT,Isothiazolinones
- CAS: 26172-55-4
- EC number: 247-500-7
- MF: C4H4ClNOS
- MW: 149.6
Description of first aid measures
If inhaledMove the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms and effects, both acute and delayed
no data available
Indication of any immediate medical attention and special treatment needed
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Poisons A and B
Extinguishing media
Use dry chemical, carbon dioxide or alcohol-resistant foam.
Specific Hazards Arising from the Chemical
no data available
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
Control parameters
Occupational Exposure limit valuesno data available
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
no data available
Information on basic physicochemical properties
- Physical state
Liquid
- Colour
Crystals from ligroin (60-90 deg C)
- Odour
no data available
- Melting point/freezing point
54-55 deg C
- Boiling point or initial boiling point and boiling range
200.2°C at 760 mmHg
- Flammability
no data available
- Lower and upper explosion limit/flammability limit
no data available
- Flash point
74.9°C
- Auto-ignition temperature
no data available
- Decomposition temperature
no data available
- pH
no data available
- Kinematic viscosity
no data available
- Solubility
Solubility in g/100 mL solvent: water, infinite
- Partition coefficient n-octanol/water
log Kow = 0.401 at 24 deg C
- Vapour pressure
0.328mmHg at 25°C
- Density and/or relative density
1.25 (14% aq.)
- Relative vapour density
no data available
- Particle characteristics
no data available
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
When heated to decomposition it emits toxic vapors of NOx, SOx, and Cl-
Acute toxicity
- Oral: no data available
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
Toxicity
- Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill) weight 0.58 g; Conditions: freshwater, flow through; Concentration: 300 ug/L for 96 hr (95% confidence interval: 260-340 ug/L) /14.17% purity
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, flow through; Concentration: 180 ug/L for 48 hr (95% confidence interval: 120-300 ug/L); Effect: intoxication, immobilization /14.17% purity
- Toxicity to algae: EC50; Species: Anabaena flosaquae (Blue-Green Algae); Conditions: freshwater, static; Concentration: 290 ug/L for 5 days (95% confidence interval: 190-450 ug/L); Effect: population, abundance /13.9% purity
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: Utilizing a CO2 evolution test with a freshly prepared activated sludge inoculum, 5-chloro-2-methyl-4-isothiazolin-3-one reached 38.8% and 62.0% CO2 evolution, at initial concentrations of 0.3 and 0.03 ppm, respectively, over a 28 day incubation period(1); the results classified the compound as inherently biodegradable and demonstrated a dependence on concentration(1). Microcosm studies found degradation of 5-chloro-2-methyl-4-isothiazolin-3-one to be primarily due to biodegradation based on tests using sterile controls(1). The half-life of 5-chloro-2-methyl-4-isothiazolin-3-one in an aerobic microcosm using river water and sediment was 17 days(1). At 1 ppm, [14C][5-chloro-2-methyl-4-isothiazolin-3-one], ring-labeled at the 4 and 5 carbons, degraded with a half-life of 5.4 hours in sandy loam soil that was incubated in the dark at 24-26 deg C for 64 days, and 75% of field moisture capacity(2). 5-Chloro-2-methyl-4-isothiazolin-3-one, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(3); 5-chloro-2-methyl-4-isothiazolin-3-one is a biocide(1), and the high concentration (100 ppm) may have been toxic to the microorganisms(SRC).
Bioaccumulative potential
A BCF of 5 was determined in bioaccumulation studies performed with bluegill sunfish(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
Ring-labeled [4,5-14C][5-chloro-2-methyl-4-isothiazolin-3-one] was very mobile in sandy loam, silt loam, clay loam, and sand soils under aerobic conditions; with Freundlich Kd values of 0.1-1.5, and in sandy loam sediment with a Freundlich Kd value of 4.9 being measured(1). Koc values were 30-144 for the soils and 310 for the sediment(1). According to a classification scheme(2), these Koc values suggest that 5-chloro-2-methyl-4-isothiazolin-3-one is expected to have very high to high mobility in soil and moderate mobility in sediment.
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: UN1760 (For reference only, please check.)
IMDG: UN1760 (For reference only, please check.)
IATA: UN1760 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: CORROSIVE LIQUID, N.O.S. (For reference only, please check.)
IMDG: CORROSIVE LIQUID, N.O.S. (For reference only, please check.)
IATA: CORROSIVE LIQUID, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 8 (For reference only, please check.)
IMDG: 8 (For reference only, please check.)
IATA: 8 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.