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Anecortave Acetate

Anecortave Acetate Structure
  • ₹0
  • Product name: Anecortave Acetate
  • CAS: 7753-60-8
  • MF: C23H30O5
  • MW: 386.48
  • EINECS:231-812-5
  • MDL Number:MFCD00921393
  • Synonyms:17-alpha,21-dihydroxypregna-4,9(11)-diene-3,20-dione21-acetate ;17-Hydroxypregna-4,9(11)-diene-3,20-dione-21-acetate ;anecortave acetate;17-ALPHA-HYDROXY-3,20-DIOXOPREGNA-4,9(11)-DIENE-21-YL ACETATE;21-Acetoxy-17-hydroxypregna-4,9(11)-diene-3,20-dione;21-Acetoxy-17α-hydroxypregna-4,9(11)-diene-3,20-dione;3,20-Dioxopregna-4,9(11)-diene-17,21-diol 21-acetate;3,20-Dioxopregna-4,9(11)-diene-17α,21-diol 21-acetate
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Properties

Melting point :230-234°C
alpha :D +117° (c = 1.0 in CHCl3); D22 +124° (c = 1.04 in CHCl3).
Boiling point :551.8±50.0 °C(Predicted)
Density :1.23±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly), Methanol (Slightly)
form :Solid
pka :12.47±0.60(Predicted)
color :Off-White to Beige

Safety Information

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Description

Anecortave acetate, an angiogenesis inhibitor, was launched in Australia by Alcon for the treatment of age-related macular degeneration (AMD). AMD is the leading cause of untreatable blindness among people aged 65 to 74 years in the U.S. Worldwide, approximately 20 to 25 million people suffer from AMD, a disease that until recently was untreatable. Anecortave, an angiostatic steroid, down-regulates the expression MMP-2 and -9 to exert its antiangiogenic effects.

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