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NU6140

NU6140 Structure
  • ₹0
  • Product name: NU6140
  • CAS: 444723-13-1
  • MF: C23H30N6O2
  • MW: 422.52
  • EINECS:
  • MDL Number:MFCD09264153
  • Synonyms:NU6140;4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide;4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide;Benzamide, 4-[[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino]-N,N-diethyl-;CDK,Inhibitor,NU6140,Aurora Kinase,inhibit,NU 6140,NU-6140,Cyclin dependent kinase
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :707.8±70.0 °C(Predicted)
Density :1.234±0.06 g/cm3(Predicted)
storage temp. :Desiccate at +4°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
form :White to off-white solid.
pka :9.41±0.10(Predicted)
color :White to light yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

NU 6140 is a cyclin-dependent kinase 2 (Cdk2) inhibitor (IC50 = 0.41 μM) that demonstrates 10- to 36-fold selectivity against Cdk2-cyclin A compared to Cdk1-cyclin B, Cdk4-cyclin D, Cdk5-p25, or Cdk7-cyclin H. NU 6140 has been found to induce cell-cycle arrest at the G2-M phase and to potentiate the apoptotic effect of paclitaxel in HeLa cells by inhibiting the anti-apoptotic protein, survivin.

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