NU6140
- ₹0
- Product name: NU6140
- CAS: 444723-13-1
- MF: C23H30N6O2
- MW: 422.52
- EINECS:
- MDL Number:MFCD09264153
- Synonyms:NU6140;4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide;4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide;Benzamide, 4-[[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino]-N,N-diethyl-;CDK,Inhibitor,NU6140,Aurora Kinase,inhibit,NU 6140,NU-6140,Cyclin dependent kinase
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Properties
Boiling point :707.8±70.0 °C(Predicted)
Density :1.234±0.06 g/cm3(Predicted)
storage temp. :Desiccate at +4°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
form :White to off-white solid.
pka :9.41±0.10(Predicted)
color :White to light yellow
Density :1.234±0.06 g/cm3(Predicted)
storage temp. :Desiccate at +4°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
form :White to off-white solid.
pka :9.41±0.10(Predicted)
color :White to light yellow
Safety Information
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Description
NU 6140 is a cyclin-dependent kinase 2 (Cdk2) inhibitor (IC50 = 0.41 μM) that demonstrates 10- to 36-fold selectivity against Cdk2-cyclin A compared to Cdk1-cyclin B, Cdk4-cyclin D, Cdk5-p25, or Cdk7-cyclin H. NU 6140 has been found to induce cell-cycle arrest at the G2-M phase and to potentiate the apoptotic effect of paclitaxel in HeLa cells by inhibiting the anti-apoptotic protein, survivin.More related product prices
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Suppliers and manufacturers
TargetMol Chemicals Inc.
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Aladdin Scientific
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Kaifeng Mingren Pharmaceutical Co.,LTD