UNC0379
- ₹0
- Product name: UNC0379
- CAS: 1620401-82-2
- MF: C23H35N5O2
- MW: 413.56
- EINECS:
- MDL Number:MFCD28167817
- Synonyms:UNC0379;6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine;6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine UNC0379;UNC0379, >=98%;UNC03;6,7-Dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-4-quinazolinamine;UNC0379, UNC-0379, UNC 0379;UNC 0379; UNC-0379
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Properties
Boiling point :606.3±65.0 °C(Predicted)
Density :1.168±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to 30 mg/ml)
pka :10.54±0.20(Predicted)
form :solid
color :Tan
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Density :1.168±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to 30 mg/ml)
pka :10.54±0.20(Predicted)
form :solid
color :Tan
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety Information
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Description
SET domain-containing protein 8 (SET8) is a methyltransferase that selectively mono-methylates histone H4 at lysine residue 20, an event proven to have an important role in chromatin structure and transcriptional activation. It is also a regulator of p53, mono-methylating lysine 382 of the tumor suppressor. UNC0379 is a substrate-competitive inhibitor of the lysine methyltransferase SET8 (IC50 = 7.3 μM; Kd = 18.3 μM). It is selective for SET8 over 15 other methyltransferases, including G9a and GLP (IC50s = >100 μM).More related product prices
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