a-Hydroxy Tamoxifen
- ₹0
- Product name: a-Hydroxy Tamoxifen
- CAS: 97151-02-5
- MF: C26H29NO2
- MW: 387.52
- EINECS:
- MDL Number:MFCD02101152
- Synonyms:(E)-α-Hydroxy Tamoxifen;(E)-(+/-)-alpha-Hydroxytamoxifen;α-OHTAM;Benzeneethanol, β-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]-α-methyl-, (βE)-;α-hydroxy Tamoxifen;(E)-α-Hydroxy tamoxifen;α-OHTAM;Benzeneethanol,b-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]-a-methyl-,(bE)-
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Properties
Melting point :115-119°C
Boiling point :533.8±50.0 °C(Predicted)
Density :1.094±0.06 g/cm3(Predicted)
storage temp. :Amber Vial, -20°C Freezer
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :14.13±0.20(Predicted)
form :Solid
color :Pale Yellow to Pale Beige
Boiling point :533.8±50.0 °C(Predicted)
Density :1.094±0.06 g/cm3(Predicted)
storage temp. :Amber Vial, -20°C Freezer
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :14.13±0.20(Predicted)
form :Solid
color :Pale Yellow to Pale Beige
Safety Information
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Description
Tamoxifen is a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. Although it is an antagonist of ER action in breast tissue, it acts as an ER agonist in bone and blood vessels and a partial ER agonist in uterine tissues. α-hydroxy Tamoxifen is a reactive metabolite of tamoxifen that is formed by the action of cytochrome P450 3A4 in human liver. It can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety, which in rats has been linked with hepatocarcinoma.Related product price
- ALPHA-HYDROXYMETOPROLOL
₹93040.88 - Tamoxifen
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