Entacapone
- ₹7707.4 - ₹25958.35
- Product name: Entacapone
- CAS: 130929-57-6
- MF: C14H15N3O5
- MW: 305.29
- EINECS:212-686-0
- MDL Number:MFCD00866580
- Synonyms:(E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-pmpenamide;Entacapone (150 mg);(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enaMide;2-PropenaMide,2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-;Entacapone (isomer E);(E)-2-cyano-3-(5-(dihydroxyamino)-3,4-dioxocyclohexa-1,5-dienyl)-N,N-diethylacrylamide;ENTACAPONE;2-cyano-3-(5-dihydroxyamino-3,4-dioxo-1-cyclohexa-1,5-dienyl)-n,n-diethyl-prop-2-enamide
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 10MG
- 50MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0654
- Product descriptionEntacapone ≥98% (HPLC)
- Packaging10MG
- Price₹7707.4
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0654
- Product descriptionEntacapone ≥98% (HPLC)
- Packaging50MG
- Price₹25958.35
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML0654 | Entacapone ≥98% (HPLC) | 10MG | ₹7707.4 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML0654 | Entacapone ≥98% (HPLC) | 50MG | ₹25958.35 | 2022-06-14 | Buy |
Properties
Melting point :162-1630C
Boiling point :526.6±50.0 °C(Predicted)
Density :1.392±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :pKa ~4.5(at 25℃)
color :white to light brown
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :JRURYQJSLYLRLN-BJMVGYQFSA-N
CAS DataBase Reference :130929-57-6(CAS DataBase Reference)
Boiling point :526.6±50.0 °C(Predicted)
Density :1.392±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :pKa ~4.5(at 25℃)
color :white to light brown
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :JRURYQJSLYLRLN-BJMVGYQFSA-N
CAS DataBase Reference :130929-57-6(CAS DataBase Reference)
Safety Information
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Signal word: | Warning | |||||||||||||||||||||
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Description
Catechol O-methyltransferase (COMT) is a key enzyme involved in the degradation of catecholamines including dopamine, epinephrine, and norepinephrine. COMPT metabolizes L-3,4-dihydroxyphenylalanine (L-DOPA) to 3-O-methyldopa (3-OMD), and then further to vanillactic acid, which is excreted in urine. Entacapone is a peripherally acting, selective and reversible COMT inhibitor with IC50 values of 150-300 nM in rat liver (Ki = 145 nM) and 10-20 nM in rat brain tissues. It was designed as an adjuvant to L-DOPA/dopa decarboxylase inhibitor treatment for Parkinson’s disease. Peripheral COMT inhibition with entacapone can decrease 3-OMD levels in the rat brain by 16-52% and prolong the bioavailability of L-DOPA in patients with Parkinson’s disease.More related product prices
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