KU-0063794
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- ₹15544.7 - ₹62633.45
- Product name: KU-0063794
- CAS: 938440-64-3
- MF: C25H31N5O4
- MW: 465.54
- EINECS:
- MDL Number:MFCD11977741
- Synonyms:BENZENEMETHANOL, 5-[2-[(2R,6S)-2,6-DIMETHYL-4-MORPHOLINYL]-4-(4-MORPHOLINYL)PYRIDO[2,3-D]PYRIMIDIN-7-YL]-2-METHOXY-, REL-;KU0063794;5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol;(5-(2-((2R,6S)-2,6-Dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol;rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol;KU0063794(KU63794);KU-0063794(KU 0063794);BENZENEMETHANOL, 5-[2-[(2R,6S)-2,6-DIMETHYL-4-MORPHOLINYL]-4-(4-MORPHOLINYL)PYRIDO[2,3-D]PYRIMIDIN-7
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0382
- Product descriptionKU 0063794 ≥98% (HPLC)
- Packaging5MG
- Price₹15544.7
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number475990
- Product descriptionmTOR Inhibitor IV, Ku-63794 - CAS 938440-64-3 - Calbiochem The mTOR Inhibitor IV, Ku-63794, also referenced under CAS 938440-64-3, controls the biological activity of mTOR. This small molecule/inhibitor is pri
- Packaging5MG
- Price₹17860
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0382
- Product descriptionKU 0063794 ≥98% (HPLC)
- Packaging25MG
- Price₹62633.45
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0382 | KU 0063794 ≥98% (HPLC) | 5MG | ₹15544.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 475990 | mTOR Inhibitor IV, Ku-63794 - CAS 938440-64-3 - Calbiochem The mTOR Inhibitor IV, Ku-63794, also referenced under CAS 938440-64-3, controls the biological activity of mTOR. This small molecule/inhibitor is pri | 5MG | ₹17860 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0382 | KU 0063794 ≥98% (HPLC) | 25MG | ₹62633.45 | 2022-06-14 | Buy |
Properties
Boiling point :694.3±65.0 °C(Predicted)
Density :1.248
storage temp. :2-8°C
solubility :DMSO: >2mg/mL (warmed)
form :powder
pka :14.20±0.10(Predicted)
color :white to beige
InChIKey :RFSMUFRPPYDYRD-CALCHBBNSA-N
Density :1.248
storage temp. :2-8°C
solubility :DMSO: >2mg/mL (warmed)
form :powder
pka :14.20±0.10(Predicted)
color :white to beige
InChIKey :RFSMUFRPPYDYRD-CALCHBBNSA-N
Safety Information
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| Signal word: | Danger | ||||||||||||||||
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Description
The mammalian target of rapamycin (mTOR) is a serine-threonine kinase which acts as part of two distinct complexes, TORC1 and TORC2. Both complexes (TORC1/2) play central roles in cell growth, gene expression, angiogenesis, and cell survival. Ku-0063794 is a cell-permeable, selective dual inhibitor of mTORC1 and mTORC2 (IC50 = 10 nM). It does not affect the activity of 76 other protein kinases or seven lipid kinases, including PI3Ks. Ku-0063794 inhibits cell growth by inducing G1-cell cycle arrest and autophagy, but not apoptosis, and inhibits tumor growth in a xenograft model of renal cell carcinoma (8 mg/kg for 46 days).More related product prices
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