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ChemicalBook > Product Catalogue >Biochemical Engineering >Biochemical Reagents >Acid-base indicator >α-Naphthoflavone

α-Naphthoflavone

α-Naphthoflavone Structure
  • ₹730 - ₹25679
  • Product name: α-Naphthoflavone
  • CAS: 604-59-1
  • MF: C19H12O2
  • MW: 272.3
  • EINECS:210-071-1
  • MDL Number:MFCD00004985
  • Synonyms:7,8-BENZOFLAVONE;ALPHA-NAPHTHOFLAVONE;A-NAPHTHOFLAVANONE;A-NAPHTHOFLAVONE;BENZOFLAVONE;NAPHTHOFLAVANONE, A-;NAPHTHOFLAVONE, A-;2-b)pyran-4-one,2-phenyl-4h-naphtho(
9 prices
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)
  • ALFA India
  • SRL

Package

  • 1G
  • 5G
  • 25g
  • 1Gms
  • 5Gms
  • 25Gms
  • ManufacturerTCI Chemicals (India)
  • Product numberB0056
  • Product descriptionα-Naphthoflavone
  • Packaging1G
  • Price₹2000
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB0056
  • Product descriptionα-Naphthoflavone
  • Packaging5G
  • Price₹2900
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberN5757
  • Product descriptionα-Naphthoflavone ≥98%
  • Packaging1G
  • Price₹4503.2
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberN5757
  • Product descriptionα-Naphthoflavone ≥98%
  • Packaging5G
  • Price₹5423.33
  • Updated2022-06-14
  • Buy
  • ManufacturerALFA India
  • Product numberALF-A18542-14
  • Product descriptionalpha-Naphthoflavone, 97%
  • Packaging25g
  • Price₹25679
  • Updated2022-05-26
  • Buy
  • ManufacturerALFA India
  • Product numberALF-A18542-06
  • Product descriptionalpha-Naphthoflavone, 97%
  • Packaging5g
  • Price₹5135
  • Updated2022-05-26
  • Buy
  • ManufacturerSRL
  • Product number57955
  • Product descriptiona-Naphthoflavone extrapure AR, 98%
  • Packaging1Gms
  • Price₹730
  • Updated2022-05-26
  • Buy
  • ManufacturerSRL
  • Product number57955
  • Product descriptiona-Naphthoflavone extrapure AR, 98%
  • Packaging5Gms
  • Price₹2650
  • Updated2022-05-26
  • Buy
  • ManufacturerSRL
  • Product number57955
  • Product descriptiona-Naphthoflavone extrapure AR, 98%
  • Packaging25Gms
  • Price₹12040
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) B0056 α-Naphthoflavone 1G ₹2000 2022-05-26 Buy
TCI Chemicals (India) B0056 α-Naphthoflavone 5G ₹2900 2022-05-26 Buy
Sigma-Aldrich(India) N5757 α-Naphthoflavone ≥98% 1G ₹4503.2 2022-06-14 Buy
Sigma-Aldrich(India) N5757 α-Naphthoflavone ≥98% 5G ₹5423.33 2022-06-14 Buy
ALFA India ALF-A18542-14 alpha-Naphthoflavone, 97% 25g ₹25679 2022-05-26 Buy
ALFA India ALF-A18542-06 alpha-Naphthoflavone, 97% 5g ₹5135 2022-05-26 Buy
SRL 57955 a-Naphthoflavone extrapure AR, 98% 1Gms ₹730 2022-05-26 Buy
SRL 57955 a-Naphthoflavone extrapure AR, 98% 5Gms ₹2650 2022-05-26 Buy
SRL 57955 a-Naphthoflavone extrapure AR, 98% 25Gms ₹12040 2022-05-26 Buy

Properties

Melting point :153-157 °C (lit.)
Boiling point :375.35°C (rough estimate)
Density :1.1382 (rough estimate)
refractive index :1.5510 (estimate)
storage temp. :2-8°C
solubility :Chloroform (Slightly), Ethyl Acetate (Slightly)
form :Crystalline Powder or Crystals
color :yellow
BRN :210862
Stability :Stable. Incompatible with strong oxidizing agents.
LogP :5.003 (est)
CAS DataBase Reference :604-59-1(CAS DataBase Reference)
EPA Substance Registry System :4H-Naphtho[1,2-b]pyran-4-one, 2-phenyl- (604-59-1)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.

Description

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. α-Naphthoflavone is a flavone that modulates xenobiotic metabolism at several points. It antagonizes AhR, blocking the expression of phase I and II genes at nanomolar concentrations, although it can agonize AhR at higher concentrations (10 μM). α-Naphthoflavone inhibits CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50s = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4 μM). Dietary α-naphthoflavone can contribute to carcinogenesis in the presence of synthetic estrogens.

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