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ChemicalBook >> CAS DataBase List >> N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide

N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide

N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide price.
  • $44 - $12026
  • Product name: N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
  • CAS: 1072959-67-1
  • MF: C22H24N4O4
  • MW: 408.45
  • EINECS:
  • MDL Number:MFCD16619390
  • Synonyms:SR3677;N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl-2,3-dihydro-1,4-benzodioxin-2-carboxamidehydrochloride;SR 3677 hydrochloride;N-(2-(2-(diMethylaMino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxaMide;SR 3677 dihydrochloride;N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-ca;N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-benzo[b][1,4]dioxin-2-carboxamide;N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
Price35 Properties Safety Information Description
35 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
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  • 25mg
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  • 250mg
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  • 5g
  • 10g
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1083-M010
  • Product descriptionSR 3677 ≥95%
  • Packaging10mg
  • Price$227
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000777
  • Product descriptionSR 3677 95.00%
  • Packaging1MG
  • Price$228.9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000777
  • Product descriptionSR 3677 95.00%
  • Packaging10MG
  • Price$757.97
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000777
  • Product descriptionSR 3677 95.00%
  • Packaging50MG
  • Price$1478.35
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1294
  • Product descriptionSR 3677
  • Packaging10mg
  • Price$189
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1294
  • Product descriptionSR 3677
  • Packaging50mg
  • Price$605
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1294
  • Product descriptionSR 3677
  • Packaging100mg
  • Price$1040
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181097
  • Product descriptionSR 3677 >98%
  • Packaging100mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181097
  • Product descriptionSR 3677 >98%
  • Packaging250mg
  • Price$1133.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181097
  • Product descriptionSR 3677 >98%
  • Packaging1000mg
  • Price$2691.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD151497
  • Product descriptionN-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
  • Packaging2mg
  • Price$59
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD151497
  • Product descriptionN-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
  • Packaging5mg
  • Price$117
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD151497
  • Product descriptionN-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
  • Packaging10mg
  • Price$203
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD151497
  • Product descriptionN-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
  • Packaging25mg
  • Price$405
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD151497
  • Product descriptionN-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
  • Packaging50mg
  • Price$704
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16708
  • Product descriptionSR 3677 ≥95%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1083-M010 SR 3677 ≥95% 10mg $227 2021-12-16 Buy
American Custom Chemicals Corporation INB0000777 SR 3677 95.00% 1MG $228.9 2021-12-16 Buy
American Custom Chemicals Corporation INB0000777 SR 3677 95.00% 10MG $757.97 2021-12-16 Buy
American Custom Chemicals Corporation INB0000777 SR 3677 95.00% 50MG $1478.35 2021-12-16 Buy
ApexBio Technology B1294 SR 3677 10mg $189 2021-12-16 Buy
ApexBio Technology B1294 SR 3677 50mg $605 2021-12-16 Buy
ApexBio Technology B1294 SR 3677 100mg $1040 2021-12-16 Buy
Biorbyt Ltd orb181097 SR 3677 >98% 100mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb181097 SR 3677 >98% 250mg $1133.9 2021-12-16 Buy
Biorbyt Ltd orb181097 SR 3677 >98% 1000mg $2691.1 2021-12-16 Buy
Biosynth Carbosynth FD151497 N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide 2mg $59 2021-12-16 Buy
Biosynth Carbosynth FD151497 N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide 5mg $117 2021-12-16 Buy
Biosynth Carbosynth FD151497 N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide 10mg $203 2021-12-16 Buy
Biosynth Carbosynth FD151497 N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide 25mg $405 2021-12-16 Buy
Biosynth Carbosynth FD151497 N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide 50mg $704 2021-12-16 Buy
Cayman Chemical 16708 SR 3677 ≥95% 1mg $44 2024-03-01 Buy
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Properties

Boiling point :646.9±55.0 °C(Predicted)
Density :1.298
storage temp. :Desiccate at RT
solubility :DMSO: soluble15mg/mL, clear
pka :11.90±0.70(Predicted)
form :powder
color :white to light brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SR 3677 is a potent, ATP-competitive inhibitor of Rho-associated kinases (ROCKs) that shows greater potency against ROCK-II than ROCK-I in enzyme and cell-based assays (IC50 values are 3 and 56 nM, respectively). At 3 μM, SR 3677 inhibits only 5 (Akt3, Clk1, Clk2, Clk4, Lats2) out of 353 kinases with greater than 50% inhibition. SR 3677 is efficacious at inhibiting myosin light chain phosphorylation and increasing aqueous humor outflow in porcine eyes in an ex vivo model of glaucoma treatment.

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