5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine
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- $36 - $1900
- Product name: 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine
- CAS: 1225037-39-7
- MF: C17H20F3N7O2
- MW: 411.38
- EINECS:-0
- MDL Number:MFCD28902193
- Synonyms:5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine;PI3K-IN-2;PQR309;Bimiralisib;PQR309 Bimiralisib;CS-2024;PQR309;PQR 309;PQR-309;Bimiralisib (PQR309)(free base)
15 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- ManufacturerAK Scientific
- Product number0926DP
- Product descriptionBimiralisib
- Packaging10mg
- Price$421
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number23441
- Product descriptionBimiralisib ≥98%
- Packaging1mg
- Price$36
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23441
- Product descriptionBimiralisib ≥98%
- Packaging5mg
- Price$155
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23441
- Product descriptionBimiralisib ≥98%
- Packaging10mg
- Price$290
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23441
- Product descriptionBimiralisib ≥98%
- Packaging25mg
- Price$638
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-4672
- Product descriptionBimiralisib 98.74%
- Packaging2mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4672
- Product descriptionBimiralisib 98.74%
- Packaging5mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4672
- Product descriptionBimiralisib 98.74%
- Packaging10mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4672
- Product descriptionBimiralisib 98.74%
- Packaging50mg
- Price$440
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4672
- Product descriptionBimiralisib 98.74%
- Packaging100mg
- Price$640
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004212
- Product descriptionPQR309 98+%
- Packaging25mg
- Price$261
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004212
- Product descriptionPQR309 98+%
- Packaging50mg
- Price$445
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004212
- Product descriptionPQR309 98+%
- Packaging100mg
- Price$748
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8335
- Product descriptionPQR-309(Bimiralisib) >98%
- Packaging100mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8335
- Product descriptionPQR-309(Bimiralisib) >98%
- Packaging1g
- Price$1900
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 0926DP | Bimiralisib | 10mg | $421 | 2021-12-16 | Buy |
| Cayman Chemical | 23441 | Bimiralisib ≥98% | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 23441 | Bimiralisib ≥98% | 5mg | $155 | 2024-03-01 | Buy |
| Cayman Chemical | 23441 | Bimiralisib ≥98% | 10mg | $290 | 2024-03-01 | Buy |
| Cayman Chemical | 23441 | Bimiralisib ≥98% | 25mg | $638 | 2024-03-01 | Buy |
| ChemScene | CS-4672 | Bimiralisib 98.74% | 2mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-4672 | Bimiralisib 98.74% | 5mg | $100 | 2021-12-16 | Buy |
| ChemScene | CS-4672 | Bimiralisib 98.74% | 10mg | $140 | 2021-12-16 | Buy |
| ChemScene | CS-4672 | Bimiralisib 98.74% | 50mg | $440 | 2021-12-16 | Buy |
| ChemScene | CS-4672 | Bimiralisib 98.74% | 100mg | $640 | 2021-12-16 | Buy |
| Crysdot | CD31004212 | PQR309 98+% | 25mg | $261 | 2021-12-16 | Buy |
| Crysdot | CD31004212 | PQR309 98+% | 50mg | $445 | 2021-12-16 | Buy |
| Crysdot | CD31004212 | PQR309 98+% | 100mg | $748 | 2021-12-16 | Buy |
| DC Chemicals | DC8335 | PQR-309(Bimiralisib) >98% | 100mg | $550 | 2021-12-16 | Buy |
| DC Chemicals | DC8335 | PQR-309(Bimiralisib) >98% | 1g | $1900 | 2021-12-16 | Buy |
Properties
Boiling point :643.7±65.0 °C(Predicted)
Density :1.418±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:22.0(Max Conc. mg/mL);53.48(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);24.31(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);4.86(Max Conc. mM) form :A crystalline solid
pka :4.92±0.10(Predicted)
color :White to gray
Density :1.418±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:22.0(Max Conc. mg/mL);53.48(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);24.31(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);4.86(Max Conc. mM) form :A crystalline solid
pka :4.92±0.10(Predicted)
color :White to gray
Safety Information
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Description
Bimiralisib is a potent and orally bioavailable inhibitor of phosphatidylinositol 3-kinases (PI3Ks; IC50s = 33, 661, 708, and 451 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively) and the mammalian target of rapamycin (mTOR; IC50 = 89 nM). It is selective for these kinases over a panel of cell surface and nuclear receptors, membrane channels, transporters, kinases, proteases, and phosphodiesterases at a concentration of 10 μM. Bimiralisib has anticancer activity with an average GI50 value of 0.7 μM across the National Cancer Institute (NCI) 60 human cancer cell line panel. In vivo, bimiralisib (5-15 mg/kg) reduces tumor growth in a dose-dependent manner in a PC3 prostate cancer mouse xenograft model. Formulations containing bimiralisib are under clinical investigation for the treatment of relapsed and refractory lymphoma and advanced solid tumors.Related product price
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$1.00 /1KG
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine CAS:1225037-39-7
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine CAS:1225037-39-7