N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine
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- $44 - $1200
- Product name: N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine
- CAS: 1380432-32-5
- MF: C25H30N6O
- MW: 430.55
- EINECS:-0
- MDL Number:MFCD23143628
- Synonyms:EHop-016;EHOP-016;N4-(9-ETHYL-9H-CARBAZOL-3-YL)-N2-(3-MORPHOLIN-4-YL-PROPYL)-PYRIMIDINE-2,4-DIAMINE;N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine;N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine;N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine Ehop-016;EHop-016, >=98%;EHOP016; EHOP-016; EHOP 016; EHOP016; EHOP-016; EHOP 016.;EHOP 016;EHOP016
23 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- Axon Medchem
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 5
- 5mg
- 10mg
- 25mg
- 25
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberJ96436
- Product descriptionEHOP-016
- Packaging5mg
- Price$48
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA206639
- Product descriptionEHop-016 98+%
- Packaging5mg
- Price$44
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA206639
- Product descriptionEHop-016 98+%
- Packaging10mg
- Price$58
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA206639
- Product descriptionEHop-016 98+%
- Packaging50mg
- Price$99
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2351
- Product descriptionEHop016 99%
- Packaging10mg
- Price$93.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number21557
- Product descriptionEHop-016 ≥98%
- Packaging5mg
- Price$49
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21557
- Product descriptionEHop-016 ≥98%
- Packaging10mg
- Price$87
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21557
- Product descriptionEHop-016 ≥98%
- Packaging25mg
- Price$190
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21557
- Product descriptionEHop-016 ≥98%
- Packaging50mg
- Price$356
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-4186
- Product descriptionEHop-016 99.43%
- Packaging10mg
- Price$84
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4186
- Product descriptionEHop-016 99.43%
- Packaging50mg
- Price$288
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4186
- Product descriptionEHop-016 99.43%
- Packaging100mg
- Price$480
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003684
- Product descriptionEHop-016 98+%
- Packaging50mg
- Price$273
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003684
- Product descriptionEHop-016 98+%
- Packaging100mg
- Price$455
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7728
- Product descriptionEHop-016 >98%
- Packaging100mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7728
- Product descriptionEHop-016 >98%
- Packaging250mg
- Price$600
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | J96436 | EHOP-016 | 5mg | $48 | 2021-12-16 | Buy |
| Ambeed | A206639 | EHop-016 98+% | 5mg | $44 | 2021-12-16 | Buy |
| Ambeed | A206639 | EHop-016 98+% | 10mg | $58 | 2021-12-16 | Buy |
| Ambeed | A206639 | EHop-016 98+% | 50mg | $99 | 2021-12-16 | Buy |
| Axon Medchem | Axon2351 | EHop016 99% | 10mg | $93.5 | 2021-12-16 | Buy |
| Cayman Chemical | 21557 | EHop-016 ≥98% | 5mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 21557 | EHop-016 ≥98% | 10mg | $87 | 2024-03-01 | Buy |
| Cayman Chemical | 21557 | EHop-016 ≥98% | 25mg | $190 | 2024-03-01 | Buy |
| Cayman Chemical | 21557 | EHop-016 ≥98% | 50mg | $356 | 2024-03-01 | Buy |
| ChemScene | CS-4186 | EHop-016 99.43% | 10mg | $84 | 2021-12-16 | Buy |
| ChemScene | CS-4186 | EHop-016 99.43% | 50mg | $288 | 2021-12-16 | Buy |
| ChemScene | CS-4186 | EHop-016 99.43% | 100mg | $480 | 2021-12-16 | Buy |
| Crysdot | CD31003684 | EHop-016 98+% | 50mg | $273 | 2021-12-16 | Buy |
| Crysdot | CD31003684 | EHop-016 98+% | 100mg | $455 | 2021-12-16 | Buy |
| DC Chemicals | DC7728 | EHop-016 >98% | 100mg | $300 | 2021-12-16 | Buy |
| DC Chemicals | DC7728 | EHop-016 >98% | 250mg | $600 | 2021-12-16 | Buy |
Properties
Boiling point :633.9±65.0 °C(Predicted)
Density :1.27
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :7.30±0.10(Predicted)
form :powder
color :white to beige
Density :1.27
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :7.30±0.10(Predicted)
form :powder
color :white to beige
Safety Information
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Description
EHop-016 is an inhibitor of the small Rho GTPases Rac1 and Rac3. It inhibits Rac1 activity in MDA-MB-435 breast cancer cells with an IC50 value of 1.1 μM in a Rac1 activation assay. At a concentration of 1 μM, EHop-016 inhibits 58% of Rac3 activity, and it inhibits Cdc42 activity but only at higher concentrations (5-10 μM). It also increases Rho GTPase RhoA activity ~1.3-fold at concentrations greater than 2 μM. EHop-016 (2-4 μM) inhibits Rac-regulated functions in MDA-MB-435 cells, including lamellipodia formation and serine/threonine p21-activated kinase 1 (PAK1)-mediated cell migration. In a nude mouse model of breast cancer metastasis, EHop-016 (25 mg/kg) significantly lowers mammary fat pad tumor growth, metastasis, and angiogenesis. It also inhibits mutant receptor tyrosine kinase (KIT)-induced growth in systemic mastocytosis and acute myeloid leukemia (AML) cells (≥2.5 μM).More related product prices
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$1.00 /1KG
4-N-(9-ethylcarbazol-3-yl)-2-N-(3-morpholin-4-ylpropyl)pyrimidine-2,4-diamine CAS:1380432-32-5
4-N-(9-ethylcarbazol-3-yl)-2-N-(3-morpholin-4-ylpropyl)pyrimidine-2,4-diamine CAS:1380432-32-5
