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ChemicalBook >> CAS DataBase List >> 1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE

1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE

1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE price.
  • $17 - $4718
  • Product name: 1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE
  • CAS: 162054-19-5
  • MF: C17H12F4N2O2S
  • MW: 384.35
  • EINECS:
  • MDL Number:MFCD00930300
  • Synonyms:SC-58125;1-[(4-METHYLSULFONYL)PHENYL]-3-TRIFLUOROMETHYL-5-(4-FLUOROPHENYL)PYRAZOLE;5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)pyrazole;5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-3-trifluoromethyl-1H-pyrazole;1H-Pyrazole, 5-(4-fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-;Cyclooxygenase,cancer,SC58125,COX,Inhibitor,SC-58125,inflammatory,antitumor,COX-2,edema,inhibit
Price19 Properties Safety Information Description
19 prices
Selected condition：
Brand
  • AHH
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 1mg
  • 5mg
  • 10mg
  • 10
  • 0.025g
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAHH
  • Product numberMT-18860
  • Product description1-[(4-Methylsulfonyl)phenyl]-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole 98%
  • Packaging0.025g
  • Price$415
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number1132AH
  • Product description1-[(4-Methylsulfonyl)phenyl]-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole
  • Packaging1mg
  • Price$116
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number1132AH
  • Product description1-[(4-Methylsulfonyl)phenyl]-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole
  • Packaging10mg
  • Price$229
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA432665
  • Product description5-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole 98+%
  • Packaging10mg
  • Price$186
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA432665
  • Product description5-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole 98+%
  • Packaging25mg
  • Price$315
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA432665
  • Product description5-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole 98+%
  • Packaging50mg
  • Price$473
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5347
  • Product descriptionSC58125
  • Packaging10mg
  • Price$245
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number70655
  • Product descriptionSC-58125 ≥98%
  • Packaging1mg
  • Price$17
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number70655
  • Product descriptionSC-58125 ≥98%
  • Packaging5mg
  • Price$67
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number70655
  • Product descriptionSC-58125 ≥98%
  • Packaging10mg
  • Price$118
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number70655
  • Product descriptionSC-58125 ≥98%
  • Packaging25mg
  • Price$257
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM331359
  • Product description5-(4-fluorophenyl)-1-(4-methylsulfonylphenyl)-3-(trifluoromethyl)pyrazole 95%+
  • Packaging50mg
  • Price$2408
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM331359
  • Product description5-(4-fluorophenyl)-1-(4-methylsulfonylphenyl)-3-(trifluoromethyl)pyrazole 95%+
  • Packaging100mg
  • Price$4718
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number52994
  • Product descriptionSC-58125
  • Packaging10mg
  • Price$640
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberPZ0139
  • Product descriptionSC-58125 ≥98% (HPLC)
  • Packaging5mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberPZ0139
  • Product descriptionSC-58125 ≥98% (HPLC)
  • Packaging25mg
  • Price$404
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH MT-18860 1-[(4-Methylsulfonyl)phenyl]-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole 98% 0.025g $415 2021-12-16 Buy
AK Scientific 1132AH 1-[(4-Methylsulfonyl)phenyl]-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole 1mg $116 2021-12-16 Buy
AK Scientific 1132AH 1-[(4-Methylsulfonyl)phenyl]-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole 10mg $229 2021-12-16 Buy
Ambeed A432665 5-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole 98+% 10mg $186 2021-12-16 Buy
Ambeed A432665 5-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole 98+% 25mg $315 2021-12-16 Buy
Ambeed A432665 5-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole 98+% 50mg $473 2021-12-16 Buy
ApexBio Technology B5347 SC58125 10mg $245 2021-12-16 Buy
Cayman Chemical 70655 SC-58125 ≥98% 1mg $17 2024-03-01 Buy
Cayman Chemical 70655 SC-58125 ≥98% 5mg $67 2024-03-01 Buy
Cayman Chemical 70655 SC-58125 ≥98% 10mg $118 2024-03-01 Buy
Cayman Chemical 70655 SC-58125 ≥98% 25mg $257 2024-03-01 Buy
Chemenu CM331359 5-(4-fluorophenyl)-1-(4-methylsulfonylphenyl)-3-(trifluoromethyl)pyrazole 95%+ 50mg $2408 2021-12-16 Buy
Chemenu CM331359 5-(4-fluorophenyl)-1-(4-methylsulfonylphenyl)-3-(trifluoromethyl)pyrazole 95%+ 100mg $4718 2021-12-16 Buy
Medical Isotopes, Inc. 52994 SC-58125 10mg $640 2021-12-16 Buy
Sigma-Aldrich PZ0139 SC-58125 ≥98% (HPLC) 5mg $109 2024-03-01 Buy
Sigma-Aldrich PZ0139 SC-58125 ≥98% (HPLC) 25mg $404 2024-03-01 Buy
Next Last

Properties

storage temp. :Store at +4°C
solubility :DMSO: ≥20mg/mL
form :powder
color :white to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SC-58125 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK 966 (rofecoxib), DUP-697, and celecoxib. SC-58125 is a potent and time-dependent inhibitor of COX-2. When tested on the isolated recombinant enzymes, SC-58125 is at least 150 times more potent in the inhibition of COX-2 as COX-1. In cultured HUVEC cells, SC-58125 inhibits COX-2 with an IC50 of 70 nM. It also inhibits the growth of the COX-2 expressing cell line HCA-7 in nude mice at 5-10 mg/kg when given intraperitoneally.

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Suppliers and manufacturers

Alchem Pharmtech,Inc.
TargetMol Chemicals Inc.
Amadis Chemical Company Limited J & K SCIENTIFIC LTD. 3B Pharmachem (Wuhan) International Co.,Ltd. Chemsky（shanghai）International Co.,Ltd. Guangzhou Isun Pharmaceutical Co., Ltd Tianjin Kailiqi Biotechnology Co., Ltd. MQ (shanghai) Pharmaceuticals Co., Ltd. Shanghai Jizhi Biochemical Technology Co. Ltd.