(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone
![(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone price.](/CAS/20180531/GIF/1883423-59-3.gif)
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- $73 - $1950
- Product name: (S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone
- CAS: 1883423-59-3
- MF: C18H17ClN4O
- MW: 340.81
- EINECS:-0
- MDL Number:MFCD31382190
- Synonyms:(S)-(2-(4-chlorophenyl)pyrrolidin-1-yl)(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone;MSC2530818;CPD1540;[(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl]-(3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)methanone;Methanone, [(2S)-2-(4-chlorophenyl)-1-pyrrolidinyl](3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-;Cyclin dependent kinase,Inhibitor,CDK,MSC2530818,inhibit,MSC 2530818,MSC-2530818
13 prices
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Brand
- AK Scientific
- American Custom Chemicals Corporation
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 1mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerAK Scientific
- Product number5991EF
- Product description[(2s)-2-(4-Chlorophenyl)pyrrolidin-1-Yl](3-Methyl-1h-Pyrazolo[3,4-B]pyridin-5-Yl)methanone
- Packaging1mg
- Price$179
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number5991EF
- Product description[(2s)-2-(4-Chlorophenyl)pyrrolidin-1-Yl](3-Methyl-1h-Pyrazolo[3,4-B]pyridin-5-Yl)methanone
- Packaging10mg
- Price$498
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0005703
- Product descriptionMETHANONE, [(2S)-2-(4-CHLOROPHENYL)-1-PYRROLIDINYL](3-METHYL-1H-PYRAZOLO[3,4-B]PYRIDIN-5-YL)- 95.00%
- Packaging5MG
- Price$459.97
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number29669
- Product descriptionMSC2530818
- Packaging1mg
- Price$73
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29669
- Product descriptionMSC2530818
- Packaging5mg
- Price$217
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29669
- Product descriptionMSC2530818
- Packaging10mg
- Price$359
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29669
- Product descriptionMSC2530818
- Packaging25mg
- Price$717
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-6912
- Product descriptionMSC2530818 99.69%
- Packaging5mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6912
- Product descriptionMSC2530818 99.69%
- Packaging10mg
- Price$310
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6912
- Product descriptionMSC2530818 99.69%
- Packaging25mg
- Price$660
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6912
- Product descriptionMSC2530818 99.69%
- Packaging50mg
- Price$1130
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6912
- Product descriptionMSC2530818 99.69%
- Packaging100mg
- Price$1950
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10627
- Product descriptionMSC2530818 >98%
- Packaging100mg
- Price$650
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 5991EF | [(2s)-2-(4-Chlorophenyl)pyrrolidin-1-Yl](3-Methyl-1h-Pyrazolo[3,4-B]pyridin-5-Yl)methanone | 1mg | $179 | 2021-12-16 | Buy |
| AK Scientific | 5991EF | [(2s)-2-(4-Chlorophenyl)pyrrolidin-1-Yl](3-Methyl-1h-Pyrazolo[3,4-B]pyridin-5-Yl)methanone | 10mg | $498 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0005703 | METHANONE, [(2S)-2-(4-CHLOROPHENYL)-1-PYRROLIDINYL](3-METHYL-1H-PYRAZOLO[3,4-B]PYRIDIN-5-YL)- 95.00% | 5MG | $459.97 | 2021-12-16 | Buy |
| Cayman Chemical | 29669 | MSC2530818 | 1mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 29669 | MSC2530818 | 5mg | $217 | 2024-03-01 | Buy |
| Cayman Chemical | 29669 | MSC2530818 | 10mg | $359 | 2024-03-01 | Buy |
| Cayman Chemical | 29669 | MSC2530818 | 25mg | $717 | 2024-03-01 | Buy |
| ChemScene | CS-6912 | MSC2530818 99.69% | 5mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-6912 | MSC2530818 99.69% | 10mg | $310 | 2021-12-16 | Buy |
| ChemScene | CS-6912 | MSC2530818 99.69% | 25mg | $660 | 2021-12-16 | Buy |
| ChemScene | CS-6912 | MSC2530818 99.69% | 50mg | $1130 | 2021-12-16 | Buy |
| ChemScene | CS-6912 | MSC2530818 99.69% | 100mg | $1950 | 2021-12-16 | Buy |
| DC Chemicals | DC10627 | MSC2530818 >98% | 100mg | $650 | 2021-12-16 | Buy |
Properties
Boiling point :576.5±50.0 °C(Predicted)
Density :1.373±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.50 mg/ml; DMSO: 15 mg/ml; Ethanol: 10 mg/ml
form :A crystalline solid
pka :9.65±0.40(Predicted)
color :White to off-white
Density :1.373±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.50 mg/ml; DMSO: 15 mg/ml; Ethanol: 10 mg/ml
form :A crystalline solid
pka :9.65±0.40(Predicted)
color :White to off-white
Safety Information
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| Signal word: | Warning | |||||||
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Description
MSC2530818 is an orally bioavailable cyclin-dependent kinase 8 (Cdk8) inhibitor (IC50 = 2.6 nM). It is selective for Cdk8 over a panel of 264 kinases at 1 μM but does inhibit glycogen synthase kinase 3α (GSK3α; IC50 = 691 nM). MSC2530818 inhibits STAT1 phosphorylation in SW620 colorectal cancer cells with an IC50 value of 8 nM. It also inhibits Wnt-dependent transcription in LS 174T, COLO 205, and PA-1 cancer cells (IC50s = 32, 9, and 52 nM, respectively, in luciferase reporter assays). MSC2530818 (50 and 100 mg/kg) reduces tumor growth in a SW620 mouse xenograft model.Related product price
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