Senicapoc
- $12 - $2975
- Product name: Senicapoc
- CAS: 289656-45-7
- MF: C20H15F2NO
- MW: 323.34
- EINECS:
- MDL Number:MFCD09027349
- Synonyms:2,2-bis(4-fluorophenyl)-2-phenyl-acetamide;Benzeneacetamide, 4-fluoro-a-(4-fluorophenyl)-a-phenyl-;4-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide;4-Fluoro-A-(4-Fluorophenyl)-A-Phenyl-BenzeneacetaMide;ICA 17043;Senicapoc;ICA-17043;ICA 17043;ICA17043;Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl-
27 prices
Selected condition:
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- JR MediChem
- Matrix Scientific
Package
- 1mg
- 5mg
- 10mg
- 50mg
- 100mg
- 250mg
- 500mg
- 0.5G
- 1g
- 5g
- 10g
- ManufacturerAK Scientific
- Product numberY5374
- Product description2,2-bis(4-Fluorophenyl)-2-phenylacetamide
- Packaging10mg
- Price$84
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY5374
- Product description2,2-bis(4-Fluorophenyl)-2-phenylacetamide
- Packaging50mg
- Price$112
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY5374
- Product description2,2-bis(4-Fluorophenyl)-2-phenylacetamide
- Packaging250mg
- Price$172
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA239412
- Product descriptionSenicapoc 98+%
- Packaging1mg
- Price$12
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA239412
- Product descriptionSenicapoc 98+%
- Packaging5mg
- Price$27
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA239412
- Product descriptionSenicapoc 98+%
- Packaging10mg
- Price$39
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA239412
- Product descriptionSenicapoc 98+%
- Packaging50mg
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA239412
- Product descriptionSenicapoc 98+%
- Packaging100mg
- Price$132
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA239412
- Product descriptionSenicapoc 98+%
- Packaging250mg
- Price$195
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA239412
- Product descriptionSenicapoc 98+%
- Packaging1g
- Price$498
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA239412
- Product descriptionSenicapoc 98+%
- Packaging10g
- Price$2975
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008101
- Product descriptionICA-17043 95.00%
- Packaging0.5G
- Price$414
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFS100781
- Product descriptionSenicapoc
- Packaging10mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFS100781
- Product descriptionSenicapoc
- Packaging50mg
- Price$262.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number29679
- Product descriptionSenicapoc
- Packaging50mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29679
- Product descriptionSenicapoc
- Packaging100mg
- Price$57
- Updated2024-03-01
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | Y5374 | 2,2-bis(4-Fluorophenyl)-2-phenylacetamide | 10mg | $84 | 2021-12-16 | Buy |
AK Scientific | Y5374 | 2,2-bis(4-Fluorophenyl)-2-phenylacetamide | 50mg | $112 | 2021-12-16 | Buy |
AK Scientific | Y5374 | 2,2-bis(4-Fluorophenyl)-2-phenylacetamide | 250mg | $172 | 2021-12-16 | Buy |
Ambeed | A239412 | Senicapoc 98+% | 1mg | $12 | 2021-12-16 | Buy |
Ambeed | A239412 | Senicapoc 98+% | 5mg | $27 | 2021-12-16 | Buy |
Ambeed | A239412 | Senicapoc 98+% | 10mg | $39 | 2021-12-16 | Buy |
Ambeed | A239412 | Senicapoc 98+% | 50mg | $88 | 2021-12-16 | Buy |
Ambeed | A239412 | Senicapoc 98+% | 100mg | $132 | 2021-12-16 | Buy |
Ambeed | A239412 | Senicapoc 98+% | 250mg | $195 | 2021-12-16 | Buy |
Ambeed | A239412 | Senicapoc 98+% | 1g | $498 | 2021-12-16 | Buy |
Ambeed | A239412 | Senicapoc 98+% | 10g | $2975 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0008101 | ICA-17043 95.00% | 0.5G | $414 | 2021-12-16 | Buy |
Biosynth Carbosynth | FS100781 | Senicapoc | 10mg | $75 | 2021-12-16 | Buy |
Biosynth Carbosynth | FS100781 | Senicapoc | 50mg | $262.5 | 2021-12-16 | Buy |
Cayman Chemical | 29679 | Senicapoc | 50mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 29679 | Senicapoc | 100mg | $57 | 2024-03-01 | Buy |
Properties
Melting point :180-181 °C(Solv: hexane (110-54-3); dichloromethane (75-09-2))
Boiling point :460.7±45.0 °C(Predicted)
Density :1.250±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO : 50 mg/mL (154.64 mM; Need ultrasonic)
form :Powder
pka :15.41±0.50(Predicted)
color :White to yellow
InChI :InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
InChIKey :SCTZUZTYRMOMKT-UHFFFAOYSA-N
SMILES :C(C1C=CC=CC=1)(C1C=CC(F)=CC=1)(C1C=CC(F)=CC=1)C(=O)N
Boiling point :460.7±45.0 °C(Predicted)
Density :1.250±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO : 50 mg/mL (154.64 mM; Need ultrasonic)
form :Powder
pka :15.41±0.50(Predicted)
color :White to yellow
InChI :InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
InChIKey :SCTZUZTYRMOMKT-UHFFFAOYSA-N
SMILES :C(C1C=CC=CC=1)(C1C=CC(F)=CC=1)(C1C=CC(F)=CC=1)C(=O)N
Safety Information
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Description
Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels. It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (; IC50s = 11 and 30 nM, respectively). Senicapoc (10 mg/kg twice per day) reduces IKCa1/KCa3.1 channel activity, increases potassium levels in RBCs, and decreases erythrocyte density in the SAD transgenic mouse model of sickle cell disease. It inhibits IL-2, IFN-γ, IL-12, and IL-17A production in CD3+ T cells stimulated with phorbol 12-myristate 13-acetate (PMA; ) and ionomycin (Item Nos. 10004974 | 11932) when used at a concentration of 1 μM. Senicapoc (100 mg/kg) increases the paw withdrawal threshold in a rat model of chronic constriction injury (CCI) of the sciatic nerve.Related product price
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$12-2975