2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide
![2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide price.](/CAS/GIF/290297-26-6.gif)
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- $14 - $3500
- Product name: 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide
- CAS: 290297-26-6
- MF: C30H32F6N4O
- MW: 578.59
- EINECS:1308068-626-2
- MDL Number:MFCD25976831
- Synonyms:2-[3,5-Bis(trifluoromethyl)phenyl]-N-[6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl]-N-methylisobutyramide;2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide;Ro 67-31898/000;2-(3,5-bis(trifluoroMethyl)phenyl)-N,2- diMethyl-N-(6-(4-Methylpiperazin-1-yl)-4- o-tolylpyridin-3-yl)propanaMide;BenzeneacetaMide, N,a,a-triMethyl-N-[4-(2-Methylphenyl)-6-(4-Methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoroMethyl)-;2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-;Ro 67-31898;Netupitan
42 prices
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Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- ManufacturerAK Scientific
- Product numberJ98850
- Product descriptionNetupitant
- Packaging100mg
- Price$460
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3924AH
- Product descriptionNetupitant
- Packaging100mg
- Price$614
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA913871
- Product descriptionNetupitant 98+%
- Packaging1mg
- Price$14
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA913871
- Product descriptionNetupitant 98+%
- Packaging5mg
- Price$27
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA913871
- Product descriptionNetupitant 98+%
- Packaging10mg
- Price$35
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA913871
- Product descriptionNetupitant 98+%
- Packaging25mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA913871
- Product descriptionNetupitant 98+%
- Packaging50mg
- Price$58
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA913871
- Product descriptionNetupitant 98+%
- Packaging100mg
- Price$79
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA913871
- Product descriptionNetupitant 98+%
- Packaging250mg
- Price$161
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA913871
- Product descriptionNetupitant 98+%
- Packaging1g
- Price$380
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberBRS0000944
- Product description2-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-N-[6-(4-METHYLPIPERAZIN-1-YL)-4-(ORTHO-TOLYL)PYRIDIN-3-YL]-N-METHYL ISOBUTYRAMIDE 98.00%
- Packaging5MG
- Price$497.78
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6142
- Product descriptionNetupitant
- Packaging5mg
- Price$103
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFN103430
- Product descriptionNetupitant
- Packaging100mg
- Price$730
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFN103430
- Product descriptionNetupitant
- Packaging50mg
- Price$505
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFN103430
- Product descriptionNetupitant
- Packaging25mg
- Price$325
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFN103430
- Product descriptionNetupitant
- Packaging10mg
- Price$205
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | J98850 | Netupitant | 100mg | $460 | 2021-12-16 | Buy |
| AK Scientific | 3924AH | Netupitant | 100mg | $614 | 2021-12-16 | Buy |
| Ambeed | A913871 | Netupitant 98+% | 1mg | $14 | 2021-12-16 | Buy |
| Ambeed | A913871 | Netupitant 98+% | 5mg | $27 | 2021-12-16 | Buy |
| Ambeed | A913871 | Netupitant 98+% | 10mg | $35 | 2021-12-16 | Buy |
| Ambeed | A913871 | Netupitant 98+% | 25mg | $45 | 2021-12-16 | Buy |
| Ambeed | A913871 | Netupitant 98+% | 50mg | $58 | 2021-12-16 | Buy |
| Ambeed | A913871 | Netupitant 98+% | 100mg | $79 | 2021-12-16 | Buy |
| Ambeed | A913871 | Netupitant 98+% | 250mg | $161 | 2021-12-16 | Buy |
| Ambeed | A913871 | Netupitant 98+% | 1g | $380 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BRS0000944 | 2-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-N-[6-(4-METHYLPIPERAZIN-1-YL)-4-(ORTHO-TOLYL)PYRIDIN-3-YL]-N-METHYL ISOBUTYRAMIDE 98.00% | 5MG | $497.78 | 2021-12-16 | Buy |
| ApexBio Technology | B6142 | Netupitant | 5mg | $103 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FN103430 | Netupitant | 100mg | $730 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FN103430 | Netupitant | 50mg | $505 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FN103430 | Netupitant | 25mg | $325 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FN103430 | Netupitant | 10mg | $205 | 2021-12-16 | Buy |
Properties
Melting point :156.2-160.0 °C
Boiling point :597.4±50.0 °C(Predicted)
Density :1.255
storage temp. :2-8°C
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka :7.89±0.38(Predicted)
form :Solid
color :White to Off-White
InChIKey :WAXQNWCZJDTGBU-UHFFFAOYSA-N
SMILES :C(N(C)C1=C(C2C=CC=CC=2C)C=C(N2CCN(C)CC2)N=C1)(=O)C(C1C=C(C(F)(F)F)C=C(C(F)(F)F)C=1)(C)C
Boiling point :597.4±50.0 °C(Predicted)
Density :1.255
storage temp. :2-8°C
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka :7.89±0.38(Predicted)
form :Solid
color :White to Off-White
InChIKey :WAXQNWCZJDTGBU-UHFFFAOYSA-N
SMILES :C(N(C)C1=C(C2C=CC=CC=2C)C=C(N2CCN(C)CC2)N=C1)(=O)C(C1C=C(C(F)(F)F)C=C(C(F)(F)F)C=1)(C)C
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Netupitant, originally developed by Helsinn Healthcare and later licensed to Eisai, Inc., was approved in the USA in October 2014 for the treatment of chemotherapy-induced nausea and emesis. Akynzeo ® is a fixed-dose combination of the new drug netupitant and the previously-approved 5-HT3 antagonist palonosetron. While palonosetron obtained approval previously for treating nausea and emesis occurring within the first 24 hours (acute phase) after chemotherapy, netupitant provides a synergistic effect with palonosetron, assisting in prevention of nausea and emesis in later stages following chemotherapy (25–120 h after chemotherapy treatment). Several clinical trials showed that this combination of netupitant and palonosetron (Akynzeo ?), in comparison to treatment with palonosetron treatment alone, led to an improved percentage of patients in all phases who did not experience any nausea and emesis after undergoing chemotherapy. Netupitant itself joins the class of selective Neurokinin- 1 (NK1) receptor antagonists which, in addition to their use for treating chemotherapy-induced nausea and emesis, also play an important role as therapies for depression and anxiety.Suppliers and manufacturers
Aceschem Inc.
Beijing Cooperate Pharmaceutical Co.,Ltd
Henan Tianfu Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
TianYuan Pharmaceutical CO.,LTD
BOC Sciences
