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ChemicalBook >> CAS DataBase List >> 2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-

2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-

2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- price.
  • $28 - $7252.25
  • Product name: 2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-
  • CAS: 404951-53-7
  • MF: C22H25N3O3
  • MW: 379.45
  • EINECS:
  • MDL Number:
  • Synonyms:2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-;Dacinostat(NVP-LAQ 824);LAQ-824;LAQ824 (Dacinostat);(E)-3-(4-(((2-(1H-indol-3-yl)ethyl)(2-hydroxyethyl)amino)methyl)phenyl)-N-hydroxyacrylamide;(E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]meth yl]phenyl]prop-2-enamide;3-[4-[N-(2-Hydroxyethyl)-N-[2-(1H-indol-3-yl)ethyl]aminomethyl]phenyl]-2(E)-propenohydroxamic acid;LAQ824(NVP-LAQ824,Dacinostat)
Price20 Properties Safety Information Description
20 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • TRC
  • Usbiological
Package
  • 1mg
  • 1unit
  • 5mg
  • 10MG
  • 25mg
  • 50MG
  • 100MG
  • 250mg
  • 1G
  • 1000mg
  • ManufacturerAK Scientific
  • Product numberX7530
  • Product descriptionDacinostat
  • Packaging5mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000914
  • Product descriptionDACINOSTAT 95.00%
  • Packaging10MG
  • Price$885.31
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000914
  • Product descriptionDACINOSTAT 95.00%
  • Packaging50MG
  • Price$1370.41
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000914
  • Product descriptionDACINOSTAT 95.00%
  • Packaging100MG
  • Price$2194.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000914
  • Product descriptionDACINOSTAT 95.00%
  • Packaging1G
  • Price$7252.25
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4103
  • Product descriptionLAQ824(NVP-LAQ824,Dacinostat)
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180988
  • Product descriptionDacinostat (NVP-LAQ824, LAQ824) >98%
  • Packaging100mg
  • Price$690.2
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180988
  • Product descriptionDacinostat (NVP-LAQ824, LAQ824) >98%
  • Packaging250mg
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180988
  • Product descriptionDacinostat (NVP-LAQ824, LAQ824) >98%
  • Packaging1000mg
  • Price$2541.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD43358
  • Product descriptionDacinostat
  • Packaging10mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD43358
  • Product descriptionDacinostat
  • Packaging50mg
  • Price$437.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16427
  • Product descriptionLAQ824 ≥95%
  • Packaging1mg
  • Price$35
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16427
  • Product descriptionLAQ824 ≥95%
  • Packaging5mg
  • Price$123
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16427
  • Product descriptionLAQ824 ≥95%
  • Packaging10mg
  • Price$210
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1974
  • Product descriptionDacinostat 98.45%
  • Packaging10mg
  • Price$216
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1974
  • Product descriptionDacinostat 98.45%
  • Packaging50mg
  • Price$576
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7530 Dacinostat 5mg $280 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000914 DACINOSTAT 95.00% 10MG $885.31 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000914 DACINOSTAT 95.00% 50MG $1370.41 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000914 DACINOSTAT 95.00% 100MG $2194.5 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000914 DACINOSTAT 95.00% 1G $7252.25 2021-12-16 Buy
ApexBio Technology A4103 LAQ824(NVP-LAQ824,Dacinostat) 1unit $28 2021-12-16 Buy
Biorbyt Ltd orb180988 Dacinostat (NVP-LAQ824, LAQ824) >98% 100mg $690.2 2021-12-16 Buy
Biorbyt Ltd orb180988 Dacinostat (NVP-LAQ824, LAQ824) >98% 250mg $1208.7 2021-12-16 Buy
Biorbyt Ltd orb180988 Dacinostat (NVP-LAQ824, LAQ824) >98% 1000mg $2541.5 2021-12-16 Buy
Biosynth Carbosynth FD43358 Dacinostat 10mg $125 2021-12-16 Buy
Biosynth Carbosynth FD43358 Dacinostat 50mg $437.5 2021-12-16 Buy
Cayman Chemical 16427 LAQ824 ≥95% 1mg $35 2024-03-01 Buy
Cayman Chemical 16427 LAQ824 ≥95% 5mg $123 2024-03-01 Buy
Cayman Chemical 16427 LAQ824 ≥95% 10mg $210 2024-03-01 Buy
ChemScene CS-1974 Dacinostat 98.45% 10mg $216 2021-12-16 Buy
ChemScene CS-1974 Dacinostat 98.45% 50mg $576 2021-12-16 Buy
Next Last

Properties

Density :1.290±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥17.45 mg/mL in DMSO
form :solid
pka :8.81±0.23(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

LAQ824 is a hydroxamate-based inhibitor of histone deacetylases (HDACs) with an IC50 value of 30 nM. It inhibits the growth of colon, breast, prostate, and non-small cell lung cancer cell lines at concentrations of less than 1 μM. LAQ824 augments the actions of fludarabine and imatinib mesylate in human leukemia cells. Through its effects on HDACs, LAQ824 induces acetylation of histones, α-tubulin, and heat shock protein 90 (Hsp90). Acetylation of Hsp90 blocks its chaperone function, resulting in changes in levels of several client proteins, including estrogen receptor-α, Hsp72, and Raf-1.

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Suppliers and manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-
$0.00 /25kg
2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- CAS:404951-53-7
career henan chemical co
2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-
$1.00 /100g
2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- CAS:404951-53-7
Shanghai Daken Advanced Materials Co.,Ltd
ATK CHEMICAL COMPANY LIMITED
Hubei xin bonus chemical co. LTD
CONIER CHEM AND PHARMA LIMITED
TargetMol Chemicals Inc.
CR Corporation Limited
InvivoChem
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd