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ChemicalBook >> CAS DataBase List >> 6-O-Benzylguanine

6-O-Benzylguanine

6-O-Benzylguanine price.
  • $5 - $4010
  • Product name: 6-O-Benzylguanine
  • CAS: 19916-73-5
  • MF: C12H11N5O
  • MW: 241.25
  • EINECS:1592732-453-0
  • MDL Number:MFCD00269931
  • Synonyms:O(sup 6)benzylguanidine;2-Amino-6-(benzyloxy)-9H-purine;6-(Benzyloxy)-1H-purin-2-amine;6-(PhenylMethoxy)-9H-purin-2-aMine;NSC 637037;6-oxo -benzylguanine;6-O-Benzylguanine(O6BG);9H-Purin-2-amine,6-(phenylmethoxy)-
43 prices
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Brand
  • AccelPharmtech
  • AK Scientific
  • Alfa Aesar
  • Alichem
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
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  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • SynQuest Laboratories
  • Usbiological
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  • ManufacturerAccelPharmtech
  • Product numberC1238
  • Product description6-O-Benzylguanine 97.00%
  • Packaging25G
  • Price$4010
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberC1238
  • Product description6-O-Benzylguanine 97.00%
  • Packaging5G
  • Price$2180
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberC1238
  • Product description6-O-Benzylguanine 97.00%
  • Packaging1G
  • Price$1940
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ92255
  • Product description6-O-Benzylguanine
  • Packaging1g
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ92255
  • Product description6-O-Benzylguanine
  • Packaging25g
  • Price$49
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ10132
  • Product description6-O-Benzylguanine
  • Packaging1g
  • Price$79
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberH60274
  • Product descriptionO6-Benzylguanine, 98%
  • Packaging250mg
  • Price$47.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAlichem
  • Product number19916735
  • Product description6-(Benzyloxy)-7H-purin-2-amine
  • Packaging25g
  • Price$150.48
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number19916735
  • Product description6-(Benzyloxy)-7H-purin-2-amine
  • Packaging100g
  • Price$371.42
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA394978
  • Product description6-(Benzyloxy)-7H-purin-2-amine 98%
  • Packaging100mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA394978
  • Product description6-(Benzyloxy)-7H-purin-2-amine 98%
  • Packaging1g
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA394978
  • Product description6-(Benzyloxy)-7H-purin-2-amine 98%
  • Packaging5g
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA394978
  • Product description6-(Benzyloxy)-7H-purin-2-amine 98%
  • Packaging10g
  • Price$16
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA394978
  • Product description6-(Benzyloxy)-7H-purin-2-amine 98%
  • Packaging25g
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA394978
  • Product description6-(Benzyloxy)-7H-purin-2-amine 98%
  • Packaging100g
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA394978
  • Product description6-(Benzyloxy)-7H-purin-2-amine 98%
  • Packaging500g
  • Price$421
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AccelPharmtech C1238 6-O-Benzylguanine 97.00% 25G $4010 2021-12-16 Buy
AccelPharmtech C1238 6-O-Benzylguanine 97.00% 5G $2180 2021-12-16 Buy
AccelPharmtech C1238 6-O-Benzylguanine 97.00% 1G $1940 2021-12-16 Buy
AK Scientific J92255 6-O-Benzylguanine 1g $10 2021-12-16 Buy
AK Scientific J92255 6-O-Benzylguanine 25g $49 2021-12-16 Buy
AK Scientific J10132 6-O-Benzylguanine 1g $79 2021-12-16 Buy
Alfa Aesar H60274 O6-Benzylguanine, 98% 250mg $47.65 2024-03-01 Buy
Alichem 19916735 6-(Benzyloxy)-7H-purin-2-amine 25g $150.48 2021-12-16 Buy
Alichem 19916735 6-(Benzyloxy)-7H-purin-2-amine 100g $371.42 2021-12-16 Buy
Ambeed A394978 6-(Benzyloxy)-7H-purin-2-amine 98% 100mg $5 2021-12-16 Buy
Ambeed A394978 6-(Benzyloxy)-7H-purin-2-amine 98% 1g $6 2021-12-16 Buy
Ambeed A394978 6-(Benzyloxy)-7H-purin-2-amine 98% 5g $9 2021-12-16 Buy
Ambeed A394978 6-(Benzyloxy)-7H-purin-2-amine 98% 10g $16 2021-12-16 Buy
Ambeed A394978 6-(Benzyloxy)-7H-purin-2-amine 98% 25g $28 2021-12-16 Buy
Ambeed A394978 6-(Benzyloxy)-7H-purin-2-amine 98% 100g $105 2021-12-16 Buy
Ambeed A394978 6-(Benzyloxy)-7H-purin-2-amine 98% 500g $421 2021-12-16 Buy

Properties

Melting point :193(dec.)
Boiling point :459.3±55.0 °C(Predicted)
Density :1.48±0.1 g/cm3(Predicted)
storage temp. :room temp
solubility :methanol: 20 mg/mL
form :solid
pka :7.47±0.20(Predicted)
color :Off-White to Light Yellow
CAS DataBase Reference :19916-73-5(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

O6-Alkylguanine-DNA alkyltransferase (AGT, also known as methylguanine DNA methyltransferase, or MGMT) is a DNA repair protein that directly removes alkyl groups located on the O6-position of guanine from DNA, restoring DNA integrity in a single step. In the process, AGT is alkylated and irreversibly inactivated. O6-Benzylguanine is a guanine analog with antineoplastic activity. It serves as a pseudosubstrate for AGT, transferring a benzyl moiety to the active site cysteine of the enzyme. This leads to irreversible inactivation, with 40% reduction in alkyltransferase activity of recombinant human AGT achieved at 0.06 μM. O6-Benzylguanine is effective in vivo as well as in vitro. Inactivation of AGT increases the chemotherapeutic effectiveness of chloroethylating and methylating agents.

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