N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide
![N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide price.](/CAS2/GIF/717906-29-1.gif)
|
- $32 - $2200
- Product name: N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide
- CAS: 717906-29-1
- MF: C22H21F3N6O3S
- MW: 506.5
- EINECS:
- MDL Number:MFCD16038300
- Synonyms:N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide;N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]phenyl]-N-MethylMethanesulfonaMide;N-methyl-N-(2-((2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)phenyl)methanesulfonamide;N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide PF-431396;N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-Methanesulfonamide hydrate;PF-431396 hydrate;PF 431396, >=98%;PF-431396;PF431396
18 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5mg
- 2x5mg
- 10MG
- 25mg
- 50mg
- 100MG
- 200mg
- 250mg
- 1g
- 5g
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product number2637AH
- Product descriptionN-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamide
- Packaging250mg
- Price$1204
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2568AH
- Product descriptionN-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)Amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamidehydrate
- Packaging5g
- Price$1072
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000642
- Product descriptionPF431396 95.00%
- Packaging10MG
- Price$779.63
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000642
- Product descriptionPF431396 95.00%
- Packaging100MG
- Price$2194.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8692
- Product descriptionPF-431396
- Packaging10mM(in 1mL DMSO)
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8692
- Product descriptionPF-431396
- Packaging10mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8692
- Product descriptionPF-431396
- Packaging50mg
- Price$280
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8692
- Product descriptionPF-431396
- Packaging200mg
- Price$700
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2107
- Product descriptionPF431396 99%
- Packaging2x5mg
- Price$143
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17665
- Product descriptionPF-431396 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17665
- Product descriptionPF-431396 ≥98%
- Packaging5mg
- Price$100
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17665
- Product descriptionPF-431396 ≥98%
- Packaging10mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17665
- Product descriptionPF-431396 ≥98%
- Packaging50mg
- Price$456
- Updated2024-03-01
- Buy
- ManufacturerDC Chemicals
- Product numberDC7941
- Product descriptionPF-431396 >98%
- Packaging1g
- Price$2200
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number48133
- Product descriptionPF431396
- Packaging10mg
- Price$675
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberPZ0185
- Product descriptionPF-431396 hydrate ≥98% (HPLC)
- Packaging25mg
- Price$516
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2637AH | N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamide | 250mg | $1204 | 2021-12-16 | Buy |
| AK Scientific | 2568AH | N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)Amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamidehydrate | 5g | $1072 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000642 | PF431396 95.00% | 10MG | $779.63 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000642 | PF431396 95.00% | 100MG | $2194.5 | 2021-12-16 | Buy |
| ApexBio Technology | A8692 | PF-431396 | 10mM(in 1mL DMSO) | $60 | 2021-12-16 | Buy |
| ApexBio Technology | A8692 | PF-431396 | 10mg | $80 | 2021-12-16 | Buy |
| ApexBio Technology | A8692 | PF-431396 | 50mg | $280 | 2021-12-16 | Buy |
| ApexBio Technology | A8692 | PF-431396 | 200mg | $700 | 2021-12-16 | Buy |
| Axon Medchem | Axon2107 | PF431396 99% | 2x5mg | $143 | 2021-12-16 | Buy |
| Cayman Chemical | 17665 | PF-431396 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 17665 | PF-431396 ≥98% | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 17665 | PF-431396 ≥98% | 10mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 17665 | PF-431396 ≥98% | 50mg | $456 | 2024-03-01 | Buy |
| DC Chemicals | DC7941 | PF-431396 >98% | 1g | $2200 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 48133 | PF431396 | 10mg | $675 | 2021-12-16 | Buy |
| Sigma-Aldrich | PZ0185 | PF-431396 hydrate ≥98% (HPLC) | 25mg | $516 | 2024-03-01 | Buy |
Properties
Density :1.506
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
form :powder
pka :13.66±0.20(Predicted)
color :off-white to blue-gray
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
form :powder
pka :13.66±0.20(Predicted)
color :off-white to blue-gray
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Danger | |||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||
| Precautionary statements: |
|
Description
Proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK) are nonreceptor tyrosine kinases that constitute the focal adhesion kinase subfamily. PYK2 is expressed in both bone-forming osteoblasts and bone-resorbing osteoclasts where it has a positive role in osteoclast maturation and bone resorption. PF-431396 is a pyrimidine-based dual inhibitor of FAK and PYK2 (IC50s = 2 and 11 nM, respectively). In ovariectomized rats, it has been shown to increase bone formation, promoting osteoblast recruitment and activity.More related product prices
N-Methyldiethanolamine N-Methylolacrylamide Ibrutinib 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide Fasudil hydrochloride Enzastaurin (LY317615) PF06869206 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione 947303-87-9 PF-9366 PF-6274484 PF-562271 PF-06281355 PF-05212384 PF-3758309 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid PF 573228 PF 05105679 1144035-53-9 OclacitinibRelated product price
- N-Methyldiethanolamine
$20-1183.57 - N-Methylolacrylamide
$10-156 - Ibrutinib
$5-1208.7
![N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide](https://img.chemicalbook.com/ProductImageEN/2018-8/small/1a2acf69-077d-47a2-a6d9-c4ee16bb0d03.jpg){kind=small}
