N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester
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- $40 - $4473
- Product name: N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester
- CAS: 918633-87-1
- MF: C9H16Br2N5O4P
- MW: 449.04
- EINECS:
- MDL Number:MFCD22420822
- Synonyms:N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester;TH 302;EvofosfaMide;TH-302, >=98%;TH-302 (Evofosfamide);(1-methyl-2-nitro-1H-imidazol-5-yl)methylN,N'-bis(2-bromoethyl)diamidophosphate;EOS-61724;Evofosfamide(TH 302)
17 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- Chemenu
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 30MG
- 50MG
- 100MG
- 200mg
- 250mg
- 1g
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product numberX5809
- Product description(1-Methyl-2-nitro-1H-imidazol-5-yl)methylN,N'-bis(2-bromoethyl)phosphorodiamidate
- Packaging250mg
- Price$667
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX5809
- Product description(1-Methyl-2-nitro-1H-imidazol-5-yl)methylN,N'-bis(2-bromoethyl)phosphorodiamidate
- Packaging1g
- Price$1580
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0005715
- Product descriptionTH-302 95.00%
- Packaging30MG
- Price$1558
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0005715
- Product descriptionTH-302 95.00%
- Packaging50MG
- Price$2446.5
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0005715
- Product descriptionTH-302 95.00%
- Packaging100MG
- Price$4473
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3872
- Product descriptionTH-302
- Packaging5mg
- Price$190
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3872
- Product descriptionTH-302
- Packaging10mM(in 1mL DMSO)
- Price$270
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number22195
- Product descriptionTH-302 ≥95%
- Packaging1mg
- Price$40
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22195
- Product descriptionTH-302 ≥95%
- Packaging5mg
- Price$168
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22195
- Product descriptionTH-302 ≥95%
- Packaging10mg
- Price$276
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22195
- Product descriptionTH-302 ≥95%
- Packaging25mg
- Price$590
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM191919
- Product descriptionEvofosfamide 98%
- Packaging100mg
- Price$1095
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000257
- Product descriptionEvofosfamide(TH302) 98+%
- Packaging5mg
- Price$182
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000257
- Product descriptionEvofosfamide(TH302) 98+%
- Packaging100mg
- Price$939
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7689
- Product descriptionEvofosfamide(TH-302) >98%
- Packaging100mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number67266
- Product descriptionTH-302
- Packaging200mg
- Price$3400
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X5809 | (1-Methyl-2-nitro-1H-imidazol-5-yl)methylN,N'-bis(2-bromoethyl)phosphorodiamidate | 250mg | $667 | 2021-12-16 | Buy |
| AK Scientific | X5809 | (1-Methyl-2-nitro-1H-imidazol-5-yl)methylN,N'-bis(2-bromoethyl)phosphorodiamidate | 1g | $1580 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0005715 | TH-302 95.00% | 30MG | $1558 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0005715 | TH-302 95.00% | 50MG | $2446.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0005715 | TH-302 95.00% | 100MG | $4473 | 2021-12-16 | Buy |
| ApexBio Technology | A3872 | TH-302 | 5mg | $190 | 2021-12-16 | Buy |
| ApexBio Technology | A3872 | TH-302 | 10mM(in 1mL DMSO) | $270 | 2021-12-16 | Buy |
| Cayman Chemical | 22195 | TH-302 ≥95% | 1mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 22195 | TH-302 ≥95% | 5mg | $168 | 2024-03-01 | Buy |
| Cayman Chemical | 22195 | TH-302 ≥95% | 10mg | $276 | 2024-03-01 | Buy |
| Cayman Chemical | 22195 | TH-302 ≥95% | 25mg | $590 | 2024-03-01 | Buy |
| Chemenu | CM191919 | Evofosfamide 98% | 100mg | $1095 | 2021-12-16 | Buy |
| Crysdot | CD31000257 | Evofosfamide(TH302) 98+% | 5mg | $182 | 2021-12-16 | Buy |
| Crysdot | CD31000257 | Evofosfamide(TH302) 98+% | 100mg | $939 | 2021-12-16 | Buy |
| DC Chemicals | DC7689 | Evofosfamide(TH-302) >98% | 100mg | $550 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 67266 | TH-302 | 200mg | $3400 | 2021-12-16 | Buy |
Properties
Melting point :97-98°C
Boiling point :565.4±60.0 °C(Predicted)
Density :1.97
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :0.34±0.70(Predicted)
form :Solid
color :Off-White to Pale Yellow
Boiling point :565.4±60.0 °C(Predicted)
Density :1.97
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :0.34±0.70(Predicted)
form :Solid
color :Off-White to Pale Yellow
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
TH-302 is a hypoxia-activated prodrug and DNA alkylating agent with anticancer activity. It is selectively cytotoxic to H460 human non-small cell lung cancer (NSCLC) cells grown under hypoxic over normoxic conditions (IC50s = 0.019 and 5.1 μM, respectively). Under hypoxic conditions, TH-302 undergoes a one-electron reduction to form an active radical intermediate that is then further reduced to form a DNA-intercalating hydroxylamine. Under normoxic conditions, the radical intermediate is quenched and induces reformation of the inactive nitroazole prodrug. TH-302 reduces survival of H460 and HT-29 cells in a clonogenic assay (IC50s = 0.2 and 0.2 μM, respectively). In vivo, TH-302 (33 mg/kg per day) inhibits primary tumor growth by 41% in an MIA PaCa-2-RFP mouse orthotopic xenograft model. It inhibits tumor growth by greater than 40% in Calu-6 NSCLC, H82 small cell lung, A375 melanoma, PC-3 prostate, and BxPC-3 pancreatic cancer mouse xenograft models when administered at 50 mg/kg.Related product price
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Suppliers and manufacturers
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Wuhan Topule Biopharmaceutical Co., Ltd
Shanghai Acmec Biochemical Technology Co., Ltd.
Aladdin Scientific
$7.00 /1KG
N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester CAS:918633-87-1
N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester CAS:918633-87-1