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ChemicalBook >> CAS DataBase List >> AZD9496

AZD9496

AZD9496 price.
  • $44 - $2205
  • Product name: AZD9496
  • CAS: 1639042-08-2
  • MF: C25H25F3N2O2
  • MW: 442.47
  • EINECS:
  • MDL Number:MFCD28902195
  • Synonyms:(E)-3-[3,5-Difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]phenyl]acrylic acid;3-[3,5-Difluoro-4-[(1r,3r)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1h-pyrido[3,4-b]indol-1-yl]phenyl]-2-propenoic acid;AZD9496;AZD9496, 98%, a potent and selective estrogen receptor (ERα) antagonist;CS-2107;AZD-9496;AZD 9496;2-Propenoic acid, 3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]phenyl]-, (2E)-
Price15 Properties Safety Information Description
15 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • Crysdot
  • DC Chemicals
Package
  • 1mg
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product number5289EA
  • Product description(E)-3-[3,5-Difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoicacid
  • Packaging10mg
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number5289EA
  • Product description(E)-3-[3,5-Difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoicacid
  • Packaging50mg
  • Price$640
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0005709
  • Product descriptionAZD9496 95.00%
  • Packaging5MG
  • Price$505.49
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7821
  • Product descriptionAZD9496
  • Packaging100mg
  • Price$2205
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA162614
  • Product descriptionAZD 9496
  • Packaging10mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA162614
  • Product descriptionAZD 9496
  • Packaging50mg
  • Price$437.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number21805
  • Product descriptionAZD 9496 ≥98%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21805
  • Product descriptionAZD 9496 ≥98%
  • Packaging5mg
  • Price$193
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21805
  • Product descriptionAZD 9496 ≥98%
  • Packaging10mg
  • Price$341
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21805
  • Product descriptionAZD 9496 ≥98%
  • Packaging25mg
  • Price$638
  • Updated2024-03-01
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003094
  • Product descriptionAZD9496 98+%
  • Packaging5mg
  • Price$115
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003094
  • Product descriptionAZD9496 98+%
  • Packaging10mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003094
  • Product descriptionAZD9496 98+%
  • Packaging25mg
  • Price$380
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003094
  • Product descriptionAZD9496 98+%
  • Packaging50mg
  • Price$620
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC9268
  • Product descriptionAZD9496 >98%
  • Packaging100mg
  • Price$850
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 5289EA (E)-3-[3,5-Difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoicacid 10mg $218 2021-12-16 Buy
AK Scientific 5289EA (E)-3-[3,5-Difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoicacid 50mg $640 2021-12-16 Buy
American Custom Chemicals Corporation INB0005709 AZD9496 95.00% 5MG $505.49 2021-12-16 Buy
ApexBio Technology B7821 AZD9496 100mg $2205 2021-12-16 Buy
Biosynth Carbosynth FA162614 AZD 9496 10mg $125 2021-12-16 Buy
Biosynth Carbosynth FA162614 AZD 9496 50mg $437.5 2021-12-16 Buy
Cayman Chemical 21805 AZD 9496 ≥98% 1mg $44 2024-03-01 Buy
Cayman Chemical 21805 AZD 9496 ≥98% 5mg $193 2024-03-01 Buy
Cayman Chemical 21805 AZD 9496 ≥98% 10mg $341 2024-03-01 Buy
Cayman Chemical 21805 AZD 9496 ≥98% 25mg $638 2024-03-01 Buy
Crysdot CD31003094 AZD9496 98+% 5mg $115 2021-12-16 Buy
Crysdot CD31003094 AZD9496 98+% 10mg $190 2021-12-16 Buy
Crysdot CD31003094 AZD9496 98+% 25mg $380 2021-12-16 Buy
Crysdot CD31003094 AZD9496 98+% 50mg $620 2021-12-16 Buy
DC Chemicals DC9268 AZD9496 >98% 100mg $850 2021-12-16 Buy

Properties

Boiling point :541.0±50.0 °C(Predicted)
Density :1.286±0.06 g/cm3(Predicted)
storage temp. :4°C, protect from light, stored under nitrogen
solubility :Soluble in DMSO
form :A crystalline solid
pka :4.08±0.10(Predicted)
color :Light yellow to brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

AZD 9496 is a potent and selective estrogen receptor downregulator (SERD) with an IC50 value of 0.138 nM for estrogen receptor α (ERα) downregulation. It is selective for ERα compared to other nuclear hormone receptors with IC50 values of 0.0008, 0.54, 9.2, and 30 μM for ERα, progesterone receptor (PR), glucocorticoid receptor (GR), and androgen receptor (AR), respectively. AZD 9496 decreases ERα activity (IC50 = 0.282 nM), measured via quantification of downstream PR activity, and reduces proliferation of MCF-7 breast cancer cells (IC50 = 0.0398 nM). It also inhibits MCF-7 xenograft growth in mice in a dose-dependent manner. AZD 9496 is orally bioavailable and formulations containing it are under investigation in clinical trials for treatment of ER positive breast cancer.

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Suppliers and manufacturers

career henan chemical co
AZD9496
$3.00 /1KG
AZD9496 CAS:1639042-08-2
Nanjing ChemLin Chemical Industry Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
Zhejiang ZETian Fine Chemicals Co. LTD
BOC Sciences
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Zhejiang J&C Biological Technology Co.,Limited
CR Corporation Lomited
InvivoChem
LEAP CHEM CO., LTD.