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ChemicalBook >> CAS DataBase List >> CGP 57380

CGP 57380

$32 - $5034
Product name: CGP 57380
CAS: 522629-08-9
MF: C11H9FN6
MW: 244.23
EINECS:
MDL Number:MFCD03861062
Synonyms:CGP 57380;CGP57380, N3-(4-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamine;MNK1 Inhibitor;N3-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine;CGP57380; CGP-57380;CS-1420;MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem;P 57380

Price42 Properties Safety Information Description

42 prices

Selected condition：

Brand

AK Scientific
Ambeed
American Custom Chemicals Corporation
ApexBio Technology
Apolloscientific
Axon Medchem
Biorbyt Ltd
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Sigma-Aldrich
Tocris
TRC
Usbiological

Package

10
1mg
5mg
10mg
25mg
50mg
1
100mg
250mg
50
1g
10mM(in 1mL DMSO)
1000mg

ManufacturerAK Scientific
Product number2314AH
Product description3-N-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
Packaging1mg
Price$105
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA151588
Product descriptionCGP 57380 98+%
Packaging1mg
Price$32
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA151588
Product descriptionCGP 57380 98+%
Packaging5mg
Price$79
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA151588
Product descriptionCGP 57380 98+%
Packaging10mg
Price$135
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA151588
Product descriptionCGP 57380 98+%
Packaging50mg
Price$493
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA151588
Product descriptionCGP 57380 98+%
Packaging100mg
Price$839
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA151588
Product descriptionCGP 57380 98+%
Packaging250mg
Price$1678
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA151588
Product descriptionCGP 57380 98+%
Packaging1g
Price$5034
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberKIN0000072
Product descriptionCGP 57380 95.00%
Packaging1MG
Price$148.05
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberKIN0000072
Product descriptionCGP 57380 95.00%
Packaging10MG
Price$721.59
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberKIN0000072
Product descriptionCGP 57380 95.00%
Packaging50MG
Price$1327.97
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB3570
Product descriptionCGP 57380
Packaging10mM(in 1mL DMSO)
Price$60
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB3570
Product descriptionCGP 57380
Packaging5mg
Price$81
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB3570
Product descriptionCGP 57380
Packaging10mg
Price$130
Updated2021-12-16
Buy

ManufacturerApolloscientific
Product numberBISN0182
Product descriptionCGP 57380
Packaging1mg
Price$58
Updated2021-12-16
Buy

ManufacturerApolloscientific
Product numberBISN0182
Product descriptionCGP 57380
Packaging5mg
Price$131
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
AK Scientific	2314AH	3-N-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine	1mg	$105	2021-12-16	Buy
Ambeed	A151588	CGP 57380 98+%	1mg	$32	2021-12-16	Buy
Ambeed	A151588	CGP 57380 98+%	5mg	$79	2021-12-16	Buy
Ambeed	A151588	CGP 57380 98+%	10mg	$135	2021-12-16	Buy
Ambeed	A151588	CGP 57380 98+%	50mg	$493	2021-12-16	Buy
Ambeed	A151588	CGP 57380 98+%	100mg	$839	2021-12-16	Buy
Ambeed	A151588	CGP 57380 98+%	250mg	$1678	2021-12-16	Buy
Ambeed	A151588	CGP 57380 98+%	1g	$5034	2021-12-16	Buy
American Custom Chemicals Corporation	KIN0000072	CGP 57380 95.00%	1MG	$148.05	2021-12-16	Buy
American Custom Chemicals Corporation	KIN0000072	CGP 57380 95.00%	10MG	$721.59	2021-12-16	Buy
American Custom Chemicals Corporation	KIN0000072	CGP 57380 95.00%	50MG	$1327.97	2021-12-16	Buy
ApexBio Technology	B3570	CGP 57380	10mM(in 1mL DMSO)	$60	2021-12-16	Buy
ApexBio Technology	B3570	CGP 57380	5mg	$81	2021-12-16	Buy
ApexBio Technology	B3570	CGP 57380	10mg	$130	2021-12-16	Buy
Apolloscientific	BISN0182	CGP 57380	1mg	$58	2021-12-16	Buy
Apolloscientific	BISN0182	CGP 57380	5mg	$131	2021-12-16	Buy

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Properties

storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
color :white to beige

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning		P264, P280, P305+P351+P338,P337+P313P

Precautionary statements:

P305+P351+P338

IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

CGP 57380 is a selective inhibitor of MAP kinase-interacting kinase 1 (MNK1) in vitro (IC50 = 2.2 μM), with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. It blocks the phosphorylation of eIF4E in response to TNF-α, arsenite, anisomycin, PMA, or fetal calf serum in 293 cells (IC50 = 3 μM). CGP 57380 also dose-dependently inhibits TNF-α production in RAW 264.7 cells that have been co-treated with agonists for Toll-like receptor (TLR)2 (HKLM), TLR4 (LPS), TLR6/2 (FSL), TLR7 (imiquimod), or TLR9 (CpG DNA), presumably by inhibiting MNK1.

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