CX-4945
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- $42 - $3575
- Product name: CX-4945
- CAS: 1009820-21-6
- MF: C19H12ClN3O2
- MW: 349.77
- EINECS:
- MDL Number:MFCD13184796
- Synonyms:5-[(3-chlorophenyl)amino]-Benzo[c]-2,6-naphthyridine-8-carboxylic acid;CX-4945;Silmitasertib;CX-4945 Silmitasertib;CX-4945, CX4945;Silmitasertib(CX-4945);5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylic acid CX-4945 (Silmitasertib);CX-4945, >=98%
34 prices
Selected condition：
Brand
- Adipogen Life Sciences
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Atlantic Research Chemicals
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
Package
- 1mg
- 10mM(in 1mL DMSO)
- 500μg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1000mg
- 1g
- 1gm:
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3629-M001
- Product descriptionCX-4945.hydrochloride ≥98%
- Packaging1mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3629-M025
- Product descriptionCX-4945.hydrochloride ≥98%
- Packaging25mg
- Price$495
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103748
- Product description5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylicacid 98+%
- Packaging2mg
- Price$42
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103748
- Product description5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylicacid 98+%
- Packaging5mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103748
- Product description5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylicacid 98+%
- Packaging10mg
- Price$72
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103748
- Product description5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylicacid 98+%
- Packaging50mg
- Price$122
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103748
- Product description5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylicacid 98+%
- Packaging100mg
- Price$159
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103748
- Product description5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylicacid 98+%
- Packaging250mg
- Price$313
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103748
- Product description5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylicacid 98+%
- Packaging1g
- Price$483
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000725
- Product descriptionCX-4945 95.00%
- Packaging1MG
- Price$228.9
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000725
- Product descriptionCX-4945 95.00%
- Packaging5MG
- Price$498.12
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8330
- Product descriptionCX-4945(Silmitasertib)
- Packaging5mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8330
- Product descriptionCX-4945(Silmitasertib)
- Packaging10mM(in 1mL DMSO)
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8330
- Product descriptionCX-4945(Silmitasertib)
- Packaging50mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60071
- Product descriptionSilmitasertib(CX-4945) ≥98%
- Packaging10mg
- Price$308
- Updated2021-12-16
- Buy
- ManufacturerAtlantic Research Chemicals
- Product numberCA100155
- Product description5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylicacid 95%
- Packaging1gm:
- Price$562
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3629-M001 | CX-4945.hydrochloride ≥98% | 1mg | $60 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-3629-M025 | CX-4945.hydrochloride ≥98% | 25mg | $495 | 2021-12-16 | Buy |
| Ambeed | A103748 | 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylicacid 98+% | 2mg | $42 | 2021-12-16 | Buy |
| Ambeed | A103748 | 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylicacid 98+% | 5mg | $55 | 2021-12-16 | Buy |
| Ambeed | A103748 | 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylicacid 98+% | 10mg | $72 | 2021-12-16 | Buy |
| Ambeed | A103748 | 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylicacid 98+% | 50mg | $122 | 2021-12-16 | Buy |
| Ambeed | A103748 | 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylicacid 98+% | 100mg | $159 | 2021-12-16 | Buy |
| Ambeed | A103748 | 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylicacid 98+% | 250mg | $313 | 2021-12-16 | Buy |
| Ambeed | A103748 | 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylicacid 98+% | 1g | $483 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000725 | CX-4945 95.00% | 1MG | $228.9 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000725 | CX-4945 95.00% | 5MG | $498.12 | 2021-12-16 | Buy |
| ApexBio Technology | A8330 | CX-4945(Silmitasertib) | 5mg | $80 | 2021-12-16 | Buy |
| ApexBio Technology | A8330 | CX-4945(Silmitasertib) | 10mM(in 1mL DMSO) | $90 | 2021-12-16 | Buy |
| ApexBio Technology | A8330 | CX-4945(Silmitasertib) | 50mg | $350 | 2021-12-16 | Buy |
| Arctom | CFN60071 | Silmitasertib(CX-4945) ≥98% | 10mg | $308 | 2021-12-16 | Buy |
| Atlantic Research Chemicals | CA100155 | 5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylicacid 95% | 1gm: | $562 | 2021-12-16 | Buy |
Properties
Boiling point :568.5±50.0 °C(Predicted)
Density :1.490
storage temp. :Store at -20°C
solubility :≥103.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :Orange powder.
pka :2.96±0.30(Predicted)
color :Yellow to orange
Density :1.490
storage temp. :Store at -20°C
solubility :≥103.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :Orange powder.
pka :2.96±0.30(Predicted)
color :Yellow to orange
Safety Information
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Description
CX-4945 is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki = 0.38 nM) that competes with ATP by filling the small ATP binding site on the catalytic CK2α subunit, conferring selectivity. It inhibits proliferation in a panel of cancer cell lines that overexpress CK2 and prevents tumor growth of breast and pancreatic cancer cell xenografts in mice. CX-4945 blocks survival and induces apoptosis in cancer stem cells and is effective against glioblastomas and acute myeloid leukemia cells. CX-4945 also inhibits Cdc2-like kinases (Clk; IC50s = 82.3, 3.8, and 90 nM for Clk1, Clk2, and Clk3, respectively), interfering with alternative splicing.More related product prices
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Suppliers and manufacturers
Capot Chemical Co.,Ltd.
Shanghai Daken Advanced Materials Co.,Ltd
ATK CHEMICAL COMPANY LIMITED
Biochempartner
BOC Sciences
Alchem Pharmtech,Inc.
CONIER CHEM AND PHARMA LIMITED
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
![5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid](https://img.chemicalbook.com/ProductImageEN/2019-12/small/6071f2ba-f93d-486f-9cdb-74f52151c90f.png){kind=small}