EW-7197
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- $70 - $7560
- Product name: EW-7197
- CAS: 1352608-82-2
- MF: C22H18FN7
- MW: 399.42
- EINECS:
- MDL Number:MFCD28348363
- Synonyms:EW-7197;N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazole-2-methanamine;NOV-1301;TEW-7197;N-[[4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]methyl]-2-fluoroaniline;CPD3325-A5;N-(2-Fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-1H-imidazole;CPD3325
26 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
Package
- 1mg
- 2mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number2408AH
- Product descriptionEW-7197
- Packaging25mg
- Price$448
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2408AH
- Product descriptionEW-7197
- Packaging100mg
- Price$967
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0002500
- Product descriptionEW-7197 95.00%
- Packaging5MG
- Price$498.11
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5946
- Product descriptionEW-7197
- Packaging5mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBT168124
- Product descriptionTEW 7197
- Packaging10mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBT168124
- Product descriptionTEW 7197
- Packaging25mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBT168124
- Product descriptionTEW 7197
- Packaging50mg
- Price$175
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBT168124
- Product descriptionTEW 7197
- Packaging100mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBT168124
- Product descriptionTEW 7197
- Packaging250mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19231
- Product descriptionEW-7197 ≥98%
- Packaging1mg
- Price$121
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19231
- Product descriptionEW-7197 ≥98%
- Packaging5mg
- Price$230
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19231
- Product descriptionEW-7197 ≥98%
- Packaging10mg
- Price$362
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-5679
- Product descriptionVactosertib 99.58%
- Packaging2mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5679
- Product descriptionVactosertib 99.58%
- Packaging5mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5679
- Product descriptionVactosertib 99.58%
- Packaging10mg
- Price$220
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5679
- Product descriptionVactosertib 99.58%
- Packaging25mg
- Price$490
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2408AH | EW-7197 | 25mg | $448 | 2021-12-16 | Buy |
| AK Scientific | 2408AH | EW-7197 | 100mg | $967 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0002500 | EW-7197 95.00% | 5MG | $498.11 | 2021-12-16 | Buy |
| ApexBio Technology | B5946 | EW-7197 | 5mg | $140 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BT168124 | TEW 7197 | 10mg | $70 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BT168124 | TEW 7197 | 25mg | $100 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BT168124 | TEW 7197 | 50mg | $175 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BT168124 | TEW 7197 | 100mg | $300 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BT168124 | TEW 7197 | 250mg | $600 | 2021-12-16 | Buy |
| Cayman Chemical | 19231 | EW-7197 ≥98% | 1mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 19231 | EW-7197 ≥98% | 5mg | $230 | 2024-03-01 | Buy |
| Cayman Chemical | 19231 | EW-7197 ≥98% | 10mg | $362 | 2024-03-01 | Buy |
| ChemScene | CS-5679 | Vactosertib 99.58% | 2mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-5679 | Vactosertib 99.58% | 5mg | $130 | 2021-12-16 | Buy |
| ChemScene | CS-5679 | Vactosertib 99.58% | 10mg | $220 | 2021-12-16 | Buy |
| ChemScene | CS-5679 | Vactosertib 99.58% | 25mg | $490 | 2021-12-16 | Buy |
Properties
Melting point :>85oC (dec.)
Density :1.40±0.1 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
pka :8.51±0.10(Predicted)
form :Solid
color :Pale Yellow to Light Yellow
Density :1.40±0.1 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
pka :8.51±0.10(Predicted)
form :Solid
color :Pale Yellow to Light Yellow
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
EW-7197 is a novel ALK-5 kinase inhibitor as well as TGF-β Type I Receptor Kinase Inhibitor. Study has shown that it can potently inhibit the breast to lung metastasis. Mice study has demonstrated that EW-7197 inhibited Smad/TGFβ signaling, cell migration, invasion, and lung metastasis in MMTV/c-Neu mice and 4T1 orthotopic-grafted mice. EW-7197 also inhibited the epithelial-to-mesenchymal transition (EMT) in both TGFβ-treated breast cancer cells and 4T1 orthotopic-grafted mice. Furthermore, EW-7197 enhanced cytotoxic T lymphocyte activity in 4T1 orthotopic-grafted mice and increased the survival time of 4T1-Luc and 4T1 breast tumor-bearing mice. It can also inhibit hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling. Therefore, it is a potential antitumor reagent.Related product price
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