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ChemicalBook >> CAS DataBase List >> Encorafenib (LGX818)

Encorafenib (LGX818)

Encorafenib (LGX818) price.
  • $37 - $5210.5
  • Product name: Encorafenib (LGX818)
  • CAS: 1269440-17-6
  • MF: C22H27ClFN7O4S
  • MW: 540.01
  • EINECS:
  • MDL Number:MFCD25976758
  • Synonyms:LGX 818;LGX-818;(S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate;Encorafenib (LGX818);Carbamic acid, N-[(1S)-2-[[4-[3-[5-chloro-2-fluoro-3-[(methylsulfonyl)amino]phenyl]-1-(1-methylethyl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]-1-methylethyl]-, methyl ester;LGX 818 (S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate;LGX818, >=98%;LGX818, Encorafenib
Price27 Properties Safety Information Description
27 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological
Package
  • 0.5mg
  • 500μg
  • 500ug
  • 1MG
  • 2mg
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberY1910
  • Product descriptionLGX-818
  • Packaging2mg
  • Price$225
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0018401
  • Product descriptionLGX-818 95.00%
  • Packaging1MG
  • Price$305.55
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0018401
  • Product descriptionLGX-818 95.00%
  • Packaging5MG
  • Price$495.87
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1174
  • Product descriptionLGX818
  • Packaging1mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1174
  • Product descriptionLGX818
  • Packaging5mg
  • Price$185
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180851
  • Product descriptionLGX-818(Encorafenib) >98%
  • Packaging100mg
  • Price$1431.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180851
  • Product descriptionLGX-818(Encorafenib) >98%
  • Packaging250mg
  • Price$2618
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180851
  • Product descriptionLGX-818(Encorafenib) >98%
  • Packaging1g
  • Price$5210.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC65061
  • Product descriptionLGX 818
  • Packaging1mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC65061
  • Product descriptionLGX 818
  • Packaging2mg
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC65061
  • Product descriptionLGX 818
  • Packaging5mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC65061
  • Product descriptionLGX 818
  • Packaging10mg
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC65061
  • Product descriptionLGX 818
  • Packaging25mg
  • Price$650
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16994
  • Product descriptionEncorafenib ≥98%
  • Packaging500μg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16994
  • Product descriptionEncorafenib ≥98%
  • Packaging1mg
  • Price$70
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16994
  • Product descriptionEncorafenib ≥98%
  • Packaging5mg
  • Price$163
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific Y1910 LGX-818 2mg $225 2021-12-16 Buy
American Custom Chemicals Corporation API0018401 LGX-818 95.00% 1MG $305.55 2021-12-16 Buy
American Custom Chemicals Corporation API0018401 LGX-818 95.00% 5MG $495.87 2021-12-16 Buy
ApexBio Technology B1174 LGX818 1mg $90 2021-12-16 Buy
ApexBio Technology B1174 LGX818 5mg $185 2021-12-16 Buy
Biorbyt Ltd orb180851 LGX-818(Encorafenib) >98% 100mg $1431.4 2021-12-16 Buy
Biorbyt Ltd orb180851 LGX-818(Encorafenib) >98% 250mg $2618 2021-12-16 Buy
Biorbyt Ltd orb180851 LGX-818(Encorafenib) >98% 1g $5210.5 2021-12-16 Buy
Biosynth Carbosynth FC65061 LGX 818 1mg $90 2021-12-16 Buy
Biosynth Carbosynth FC65061 LGX 818 2mg $130 2021-12-16 Buy
Biosynth Carbosynth FC65061 LGX 818 5mg $250 2021-12-16 Buy
Biosynth Carbosynth FC65061 LGX 818 10mg $400 2021-12-16 Buy
Biosynth Carbosynth FC65061 LGX 818 25mg $650 2021-12-16 Buy
Cayman Chemical 16994 Encorafenib ≥98% 500μg $37 2024-03-01 Buy
Cayman Chemical 16994 Encorafenib ≥98% 1mg $70 2024-03-01 Buy
Cayman Chemical 16994 Encorafenib ≥98% 5mg $163 2024-03-01 Buy
Next Last

Properties

Melting point :184-185°C
Density :1.45±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :5.94±0.10(Predicted)
form :Solid
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. A mutation of B-Raf in exon 15 at codon 600 where a valine is substituted by glutamic acid (V600E) has been linked to melanoma. Encorafenib is a selective inhibitor of B-RafV600E mutant melanoma cell proliferation (EC50 = 4 nM) with little activity against wild-type B-Raf or a panel of 100 other kinases (IC50s = 900 nM). At oral doses of 6 mg/kg in human melanoma xenograft models, encorafenib was shown to decrease phosphorylation of the B-Raf substrate MEK.

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Suppliers and manufacturers

career henan chemical co
Encorafenib (LGX818)
$6.60 /1KG
Encorafenib (LGX818) CAS:1269440-17-6
Shanghai Rochi Pharmaceutical Co.,Ltd.
Jinan Carbotang Biotech Co.,Ltd.
Hubei Jusheng Technology Co.,Ltd.
BOC Sciences
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Dideu Industries Group Limited
Baoji Guokang Bio-Technology Co., Ltd.
Zhejiang J&C Biological Technology Co.,Limited
Hangzhou Proserre Chemical Co.,Ltd.