GNF-2
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- $24 - $2395.3
- Product name: GNF-2
- CAS: 778270-11-4
- MF: C18H13F3N4O2
- MW: 374.32
- EINECS:200-256-5
- MDL Number:MFCD09265253
- Synonyms:3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide GNF-2;GNF-2 3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide;GNF 2, >=98%;3-(6-(4-(TRIFLUOROMETHOXY)PHENYLAMINO)PYRIMIDIN-4-YL)BENZAMIDE;Benzamide, 3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-;GNF-2;Bcr-abl Inhibitor;3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
33 prices
Selected condition：
Brand
- Abosyn
- AK Scientific
- Ambeed
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 2mg
- 5mg
- 1mg
- 50
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 10
- 1g
- ManufacturerAbosyn
- Product number61-11441
- Product description3-(6-((4-(Trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide 95-98%
- Packaging1g
- Price$890
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN5355
- Product descriptionGNF-2
- Packaging100mg
- Price$1660
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA175756
- Product descriptionGNF-2 98%
- Packaging2mg
- Price$24
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA175756
- Product descriptionGNF-2 98%
- Packaging5mg
- Price$31
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA175756
- Product descriptionGNF-2 98%
- Packaging10mg
- Price$40
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA175756
- Product descriptionGNF-2 98%
- Packaging50mg
- Price$67
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA175756
- Product descriptionGNF-2 98%
- Packaging100mg
- Price$111
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA175756
- Product descriptionGNF-2 98%
- Packaging250mg
- Price$220
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA175756
- Product descriptionGNF-2 98%
- Packaging1g
- Price$660
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8603
- Product descriptionGNF2
- Packaging25mg
- Price$329
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1882
- Product descriptionGNF2 99%
- Packaging10mg
- Price$137.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146076
- Product descriptionGNF-2 >98%
- Packaging100mg
- Price$615.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146076
- Product descriptionGNF-2 >98%
- Packaging250mg
- Price$1208.7
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146076
- Product descriptionGNF-2 >98%
- Packaging1g
- Price$2395.3
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16253
- Product descriptionGNF-2 ≥98%
- Packaging1mg
- Price$93
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16253
- Product descriptionGNF-2 ≥98%
- Packaging5mg
- Price$161
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Abosyn | 61-11441 | 3-(6-((4-(Trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide 95-98% | 1g | $890 | 2021-12-16 | Buy |
| AK Scientific | SYN5355 | GNF-2 | 100mg | $1660 | 2021-12-16 | Buy |
| Ambeed | A175756 | GNF-2 98% | 2mg | $24 | 2021-12-16 | Buy |
| Ambeed | A175756 | GNF-2 98% | 5mg | $31 | 2021-12-16 | Buy |
| Ambeed | A175756 | GNF-2 98% | 10mg | $40 | 2021-12-16 | Buy |
| Ambeed | A175756 | GNF-2 98% | 50mg | $67 | 2021-12-16 | Buy |
| Ambeed | A175756 | GNF-2 98% | 100mg | $111 | 2021-12-16 | Buy |
| Ambeed | A175756 | GNF-2 98% | 250mg | $220 | 2021-12-16 | Buy |
| Ambeed | A175756 | GNF-2 98% | 1g | $660 | 2021-12-16 | Buy |
| ApexBio Technology | A8603 | GNF2 | 25mg | $329 | 2021-12-16 | Buy |
| Axon Medchem | Axon1882 | GNF2 99% | 10mg | $137.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146076 | GNF-2 >98% | 100mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146076 | GNF-2 >98% | 250mg | $1208.7 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146076 | GNF-2 >98% | 1g | $2395.3 | 2021-12-16 | Buy |
| Cayman Chemical | 16253 | GNF-2 ≥98% | 1mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 16253 | GNF-2 ≥98% | 5mg | $161 | 2024-03-01 | Buy |
Properties
storage temp. :2-8°C
solubility :H2O: <2mg/mL
form :White solid
color :off-white
solubility :H2O: <2mg/mL
form :White solid
color :off-white
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Bcr-Abl, a fusion protein with deregulated tyrosine kinase activity, is highly expressed in chronic myelogenous leukemia. GNF-2 is a Bcr-Abl inhibitor that binds to the myristoyl binding pocket, an allosteric site distant from the active site, stabilizing the inactive form of the kinase. Thus, it can selectively inhibit Bcr-Abl phosphorylation (IC50 = 267 nM) without affecting native c-Abl or a panel of 63 additional kinases. It demonstrates exclusive antiproliferative activity toward Bcr-Abl-transformed cells (IC50 = 138 nM), inducing apoptosis in these cells without cytotoxic consequences in nontransformed cells.More related product prices
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