ISRIB (trans-isoMer)
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- $81 - $1600
- Product name: ISRIB (trans-isoMer)
- CAS: 1597403-47-8
- MF: C22H24Cl2N2O4
- MW: 451.34
- EINECS:
- MDL Number:MFCD27952932
- Synonyms:ISRIB (trans-isoMer);trans-N,N'-(cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide);N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) ISRIB(trans-isomer);Trans-ISRIB;Acetamide, N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)-;N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide];CS-1768;ISRIB - trans-ISRIB
19 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- ChemScene
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- Usbiological
Package
- 10
- 5MG
- 10mg
- 25mg
- 50
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0027387
- Product descriptionTRANS-N,N'-(CYCLOHEXANE-1,4-DIYL)BIS(2-(4-CHLOROPHENOXY)ACETAMIDE) 95.00%
- Packaging5MG
- Price$504.28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3699
- Product descriptionISRIB(trans-isomer)
- Packaging10mg
- Price$109
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2278
- Product descriptionISRIB-trans-ISRIB 99%
- Packaging10mg
- Price$104.5
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2278
- Product descriptionISRIB-trans-ISRIB 99%
- Packaging50mg
- Price$374
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16258
- Product descriptiontrans-ISRIB ≥95%
- Packaging5mg
- Price$81
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16258
- Product descriptiontrans-ISRIB ≥95%
- Packaging10mg
- Price$152
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16258
- Product descriptiontrans-ISRIB ≥95%
- Packaging25mg
- Price$356
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-3602
- Product descriptionISRIBtrans-isomer 99.37%
- Packaging10mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3602
- Product descriptionISRIBtrans-isomer 99.37%
- Packaging50mg
- Price$432
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3602
- Product descriptionISRIBtrans-isomer 99.37%
- Packaging100mg
- Price$780
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7431
- Product descriptionISRIB >98%
- Packaging100mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7431
- Product descriptionISRIB >98%
- Packaging250mg
- Price$800
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7431
- Product descriptionISRIB >98%
- Packaging1g
- Price$1600
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number46960
- Product descriptionISRIB
- Packaging25mg
- Price$800
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML0843
- Product descriptionISRIB ≥98%(HPLC)
- Packaging5mg
- Price$118
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML0843
- Product descriptionISRIB ≥98% (HPLC)
- Packaging25MG
- Price$478
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0027387 | TRANS-N,N'-(CYCLOHEXANE-1,4-DIYL)BIS(2-(4-CHLOROPHENOXY)ACETAMIDE) 95.00% | 5MG | $504.28 | 2021-12-16 | Buy |
| ApexBio Technology | B3699 | ISRIB(trans-isomer) | 10mg | $109 | 2021-12-16 | Buy |
| Axon Medchem | Axon2278 | ISRIB-trans-ISRIB 99% | 10mg | $104.5 | 2021-12-16 | Buy |
| Axon Medchem | Axon2278 | ISRIB-trans-ISRIB 99% | 50mg | $374 | 2021-12-16 | Buy |
| Cayman Chemical | 16258 | trans-ISRIB ≥95% | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 16258 | trans-ISRIB ≥95% | 10mg | $152 | 2024-03-01 | Buy |
| Cayman Chemical | 16258 | trans-ISRIB ≥95% | 25mg | $356 | 2024-03-01 | Buy |
| ChemScene | CS-3602 | ISRIBtrans-isomer 99.37% | 10mg | $130 | 2021-12-16 | Buy |
| ChemScene | CS-3602 | ISRIBtrans-isomer 99.37% | 50mg | $432 | 2021-12-16 | Buy |
| ChemScene | CS-3602 | ISRIBtrans-isomer 99.37% | 100mg | $780 | 2021-12-16 | Buy |
| DC Chemicals | DC7431 | ISRIB >98% | 100mg | $400 | 2021-12-16 | Buy |
| DC Chemicals | DC7431 | ISRIB >98% | 250mg | $800 | 2021-12-16 | Buy |
| DC Chemicals | DC7431 | ISRIB >98% | 1g | $1600 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 46960 | ISRIB | 25mg | $800 | 2021-12-16 | Buy |
| Sigma-Aldrich | SML0843 | ISRIB ≥98%(HPLC) | 5mg | $118 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0843 | ISRIB ≥98% (HPLC) | 25MG | $478 | 2024-03-01 | Buy |
Properties
Boiling point :719.0±60.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :insoluble in EtOH; insoluble in H2O; insoluble in EtOH; ≥8.96 mg/mL in DMSO with gentle warming
form :solid
pka :13.63±0.40(Predicted)
color :White to off-white
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :insoluble in EtOH; insoluble in H2O; insoluble in EtOH; ≥8.96 mg/mL in DMSO with gentle warming
form :solid
pka :13.63±0.40(Predicted)
color :White to off-white
Safety Information
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Description
Phosphorylation of eIF2α by several kinases in response to cellular stress, including accumulation of unfolded proteins in the ER, results in a decrease in overall protein synthesis but upregulation of a small number of key regulatory proteins. trans-ISRIB (Integrated Stress Response Inhibitor) is a symmetric bis-glycolamide that inhibits the eIF2α phosphorylation-mediated unfolded protein response following induction of ER stress (IC50 = 5 nM in a cell-reporter assay). Although the mechanism of action is not established, it does not directly inhibit phosphorylation of eIF2α by upstream kinases. trans-ISRIB is able to pass through the blood-brain barrier and significantly enhances learning and memory in mice and rats.Related product price
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