Ko 143
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- $80 - $2500
- Product name: Ko 143
- CAS: 461054-93-3
- MF: C26H35N3O5
- MW: 469.57
- EINECS:
- MDL Number:MFCD11042273
- Synonyms:Pyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid, 1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxo-, 1,1-dimethylethyl ester, (3S,6S,12aS)-(Ko143);Ko 143;(3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester;12a-octahydro-9-Methoxy-6-(2-Methylpropyl)-1;12aS)-;4-b]indole-3-propanoicacid;4-dioxo-;6]pyrido[3
21 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 1
- 1MG
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000360
- Product descriptionKO 143 95.00%
- Packaging1MG
- Price$641.55
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3533
- Product descriptionKo143
- Packaging10mg
- Price$244
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15215
- Product descriptionKo 143 ≥98%
- Packaging5mg
- Price$120
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15215
- Product descriptionKo 143 ≥98%
- Packaging10mg
- Price$216
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15215
- Product descriptionKo 143 ≥98%
- Packaging25mg
- Price$448
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15215
- Product descriptionKo 143 ≥98%
- Packaging50mg
- Price$834
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0298
- Product descriptionKo143 99.79%
- Packaging5mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0298
- Product descriptionKo143 99.79%
- Packaging10mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0298
- Product descriptionKo143 99.79%
- Packaging25mg
- Price$280
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0298
- Product descriptionKo143 99.79%
- Packaging50mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0298
- Product descriptionKo143 99.79%
- Packaging100mg
- Price$900
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8788
- Product descriptionKo143 >98%
- Packaging100mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8788
- Product descriptionKo143 >98%
- Packaging250mg
- Price$1200
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8788
- Product descriptionKo143 >98%
- Packaging1g
- Price$2500
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberK2144
- Product descriptionKo143 hydrate ≥98% (HPLC)
- Packaging1mg
- Price$125
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberK2144
- Product descriptionKo143 hydrate ≥98% (HPLC)
- Packaging5mg
- Price$497
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | INB0000360 | KO 143 95.00% | 1MG | $641.55 | 2021-12-16 | Buy |
| ApexBio Technology | A3533 | Ko143 | 10mg | $244 | 2021-12-16 | Buy |
| Cayman Chemical | 15215 | Ko 143 ≥98% | 5mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 15215 | Ko 143 ≥98% | 10mg | $216 | 2024-03-01 | Buy |
| Cayman Chemical | 15215 | Ko 143 ≥98% | 25mg | $448 | 2024-03-01 | Buy |
| Cayman Chemical | 15215 | Ko 143 ≥98% | 50mg | $834 | 2024-03-01 | Buy |
| ChemScene | CS-0298 | Ko143 99.79% | 5mg | $80 | 2021-12-16 | Buy |
| ChemScene | CS-0298 | Ko143 99.79% | 10mg | $140 | 2021-12-16 | Buy |
| ChemScene | CS-0298 | Ko143 99.79% | 25mg | $280 | 2021-12-16 | Buy |
| ChemScene | CS-0298 | Ko143 99.79% | 50mg | $500 | 2021-12-16 | Buy |
| ChemScene | CS-0298 | Ko143 99.79% | 100mg | $900 | 2021-12-16 | Buy |
| DC Chemicals | DC8788 | Ko143 >98% | 100mg | $650 | 2021-12-16 | Buy |
| DC Chemicals | DC8788 | Ko143 >98% | 250mg | $1200 | 2021-12-16 | Buy |
| DC Chemicals | DC8788 | Ko143 >98% | 1g | $2500 | 2021-12-16 | Buy |
| Sigma-Aldrich | K2144 | Ko143 hydrate ≥98% (HPLC) | 1mg | $125 | 2024-03-01 | Buy |
| Sigma-Aldrich | K2144 | Ko143 hydrate ≥98% (HPLC) | 5mg | $497 | 2024-03-01 | Buy |
Properties
Melting point :147 ºC
Boiling point :689.8±55.0 °C(Predicted)
Density :1.24
storage temp. :Desiccate at -20°C
solubility :DMSO: >10mg/mL
form :powder
pka :13.31±0.60(Predicted)
color :white to off-white
Stability :Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Boiling point :689.8±55.0 °C(Predicted)
Density :1.24
storage temp. :Desiccate at -20°C
solubility :DMSO: >10mg/mL
form :powder
pka :13.31±0.60(Predicted)
color :white to off-white
Stability :Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety Information
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Description
Breast cancer resistance protein (BCRP) is an ATP-binding cassette protein known also as ABCG2. While it normally functions as a high-capacity urate exporter in the renal system, it also acts as a xenobiotic transporter and contributes to multidrug resistance (e.g., to mitoxantrone) in certain types of cancer. BCRP is abundant at the intestinal epithelium and blood-brain barrier, potentially restricting the distribution of certain drugs. Ko 143 is a potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell lines (EC50s = 23 and 26 nM, respectively). It is much less effective at the transporters P-glycoprotein and multidrug resistance-associated protein 1, MRP1. Ko 143 is effective in vivo in mice.Related product price
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