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ChemicalBook >> CAS DataBase List >> Losmapimod (GW856553X)

Losmapimod (GW856553X)

Losmapimod (GW856553X) price.
  • $34 - $825
  • Product name: Losmapimod (GW856553X)
  • CAS: 585543-15-3
  • MF: C22H26FN3O2
  • MW: 383.46
  • EINECS:
  • MDL Number:MFCD16619322
  • Synonyms:6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide;GW-856553;GSK-AHAB;GW 856553X;LosMapiMod;LosMapiMod,GW-856553;Losmapimod (GW856553X);3-Pyridinecarboxamide, 6-[5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-
24 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological
Package
  • 5mg
  • 50mg
  • 100mg
  • 10mM(in 1mL DMSO)
  • 1MG
  • 10MG
  • 25mg
  • ManufacturerAK Scientific
  • Product number2523AH
  • Product descriptionLosmapimod
  • Packaging25mg
  • Price$188
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008145
  • Product descriptionLOSMAPIMOD 95.00%
  • Packaging1MG
  • Price$411
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008145
  • Product descriptionLOSMAPIMOD 95.00%
  • Packaging10MG
  • Price$510
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4620
  • Product descriptionLosmapimod
  • Packaging10mg
  • Price$68
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4620
  • Product descriptionLosmapimod
  • Packaging10mM(in 1mL DMSO)
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4620
  • Product descriptionLosmapimod
  • Packaging50mg
  • Price$269
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC102246
  • Product description6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide
  • Packaging5mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC102246
  • Product description6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide
  • Packaging10mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC102246
  • Product description6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide
  • Packaging25mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC102246
  • Product description6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide
  • Packaging50mg
  • Price$225
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC102246
  • Product description6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide
  • Packaging100mg
  • Price$350
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13614
  • Product descriptionGW 856553X ≥98%
  • Packaging1mg
  • Price$34
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13614
  • Product descriptionGW 856553X ≥98%
  • Packaging5mg
  • Price$67
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13614
  • Product descriptionGW 856553X ≥98%
  • Packaging10mg
  • Price$117
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13614
  • Product descriptionGW 856553X ≥98%
  • Packaging25mg
  • Price$249
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM178948
  • Product description6-(5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl)-N-neopentylnicotinamide 95+%
  • Packaging50mg
  • Price$216
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2523AH Losmapimod 25mg $188 2021-12-16 Buy
American Custom Chemicals Corporation API0008145 LOSMAPIMOD 95.00% 1MG $411 2021-12-16 Buy
American Custom Chemicals Corporation API0008145 LOSMAPIMOD 95.00% 10MG $510 2021-12-16 Buy
ApexBio Technology B4620 Losmapimod 10mg $68 2021-12-16 Buy
ApexBio Technology B4620 Losmapimod 10mM(in 1mL DMSO) $90 2021-12-16 Buy
ApexBio Technology B4620 Losmapimod 50mg $269 2021-12-16 Buy
Biosynth Carbosynth FC102246 6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide 5mg $65 2021-12-16 Buy
Biosynth Carbosynth FC102246 6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide 10mg $100 2021-12-16 Buy
Biosynth Carbosynth FC102246 6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide 25mg $160 2021-12-16 Buy
Biosynth Carbosynth FC102246 6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide 50mg $225 2021-12-16 Buy
Biosynth Carbosynth FC102246 6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide 100mg $350 2021-12-16 Buy
Cayman Chemical 13614 GW 856553X ≥98% 1mg $34 2024-03-01 Buy
Cayman Chemical 13614 GW 856553X ≥98% 5mg $67 2024-03-01 Buy
Cayman Chemical 13614 GW 856553X ≥98% 10mg $117 2024-03-01 Buy
Cayman Chemical 13614 GW 856553X ≥98% 25mg $249 2024-03-01 Buy
Chemenu CM178948 6-(5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl)-N-neopentylnicotinamide 95+% 50mg $216 2021-12-16 Buy

Properties

Boiling point :529.4±50.0 °C(Predicted)
Density :1.20±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥19.15 mg/mL in DMSO
form :solid
pka :7.75±0.46(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

GW 856553X is a dual inhibitor of p38α and p38β MAPK (Kis = 0.0079 and 0.025 μM, respectively, in cell-free assays). It is selective for p38α and p38β MAPK over p38γ and p38δ MAPK when used at a concentration of 10 μM. GW 856553X inhibits LPS-induced TNF-α production in isolated rat and human peripheral blood mononuclear cells (PBMCs; IC50s = 0.6 and 0.13 μM, respectively). It decreases disease severity in a mouse model of collagen-induced arthritis when administered at doses ranging from 0.8 to 20 mg/kg. GW 856553X (1.2 and 12 mg/kg) improves survival, normalizes blood pressure, and reduces increases in plasma levels of HDL, LDL, and triglycerides in spontaneously hypertensive stroke-prone rats fed a high-salt high-fat diet.

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