NMS 873
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- $38 - $2839
- Product name: NMS 873
- CAS: 1418013-75-8
- MF: C27H28N4O3S2
- MW: 520.67
- EINECS:200-256-5
- MDL Number:MFCD28009371
- Synonyms:NMS 873;NMS873;NMS-873;NMS873/NMS-873;3-[3-(CYCLOPENTYLSULFANYL)-5-({[2-METHYL-4'-(METHYLSULFONYL)-4-BI PHENYLYL]OXY}METHYL)-4H-1,2,4-TRIAZOL-4-YL]PYRIDINE;Pyridine, 3-[3-(cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]-;3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine NMS-873;NMS 873 3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine
35 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
Package
- 25
- 5
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 10mM(in 1mL DMSO)
- 1000mg
- 1g
- ManufacturerAK Scientific
- Product number2591AH
- Product description3-[3-Cyclopentylsulfanyl-5-(4'-methanesulfonyl-2-methylbiphenyl-4-yloxymethyl)-[1,2,4]triazol-4-yl]-pyridine
- Packaging5mg
- Price$153
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2591AH
- Product description3-[3-Cyclopentylsulfanyl-5-(4'-methanesulfonyl-2-methylbiphenyl-4-yloxymethyl)-[1,2,4]triazol-4-yl]-pyridine
- Packaging10mg
- Price$239
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA197765
- Product descriptionNMS-873 98+%
- Packaging5mg
- Price$242
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA197765
- Product descriptionNMS-873 98+%
- Packaging10mg
- Price$314
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA197765
- Product descriptionNMS-873 98+%
- Packaging50mg
- Price$530
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA197765
- Product descriptionNMS-873 98+%
- Packaging100mg
- Price$689
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004726
- Product description3-[3-(CYCLOPENTYLTHIO)-5-[[[2-METHYL-4'-(METHYLSULFONYL)[1,1'-BIPHENYL]-4-YL]OXY]METHYL]-4H-1,2,4-TRIAZOL-4-YL]-PYRIDINE 95.00%
- Packaging5MG
- Price$499.28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2168
- Product descriptionNMS-873
- Packaging5mg
- Price$68
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2168
- Product descriptionNMS-873
- Packaging10mM(in 1mL DMSO)
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2168
- Product descriptionNMS-873
- Packaging50mg
- Price$399
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60294
- Product descriptionNMS-873 ≥98%
- Packaging10mg
- Price$278
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181067
- Product descriptionNMS-873 >99%
- Packaging100mg
- Price$765
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181067
- Product descriptionNMS-873 >99%
- Packaging250mg
- Price$1431.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181067
- Product descriptionNMS-873 >99%
- Packaging1000mg
- Price$2839
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17674
- Product descriptionNMS-873 ≥98%
- Packaging1mg
- Price$38
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17674
- Product descriptionNMS-873 ≥98%
- Packaging5mg
- Price$111
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2591AH | 3-[3-Cyclopentylsulfanyl-5-(4'-methanesulfonyl-2-methylbiphenyl-4-yloxymethyl)-[1,2,4]triazol-4-yl]-pyridine | 5mg | $153 | 2021-12-16 | Buy |
| AK Scientific | 2591AH | 3-[3-Cyclopentylsulfanyl-5-(4'-methanesulfonyl-2-methylbiphenyl-4-yloxymethyl)-[1,2,4]triazol-4-yl]-pyridine | 10mg | $239 | 2021-12-16 | Buy |
| Ambeed | A197765 | NMS-873 98+% | 5mg | $242 | 2021-12-16 | Buy |
| Ambeed | A197765 | NMS-873 98+% | 10mg | $314 | 2021-12-16 | Buy |
| Ambeed | A197765 | NMS-873 98+% | 50mg | $530 | 2021-12-16 | Buy |
| Ambeed | A197765 | NMS-873 98+% | 100mg | $689 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004726 | 3-[3-(CYCLOPENTYLTHIO)-5-[[[2-METHYL-4'-(METHYLSULFONYL)[1,1'-BIPHENYL]-4-YL]OXY]METHYL]-4H-1,2,4-TRIAZOL-4-YL]-PYRIDINE 95.00% | 5MG | $499.28 | 2021-12-16 | Buy |
| ApexBio Technology | B2168 | NMS-873 | 5mg | $68 | 2021-12-16 | Buy |
| ApexBio Technology | B2168 | NMS-873 | 10mM(in 1mL DMSO) | $110 | 2021-12-16 | Buy |
| ApexBio Technology | B2168 | NMS-873 | 50mg | $399 | 2021-12-16 | Buy |
| Arctom | CFN60294 | NMS-873 ≥98% | 10mg | $278 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181067 | NMS-873 >99% | 100mg | $765 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181067 | NMS-873 >99% | 250mg | $1431.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181067 | NMS-873 >99% | 1000mg | $2839 | 2021-12-16 | Buy |
| Cayman Chemical | 17674 | NMS-873 ≥98% | 1mg | $38 | 2024-03-01 | Buy |
| Cayman Chemical | 17674 | NMS-873 ≥98% | 5mg | $111 | 2024-03-01 | Buy |
Properties
Melting point :>220°C (dec.)
Boiling point :769.3±70.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble25mg/mL, clear
pka :2.48±0.12(Predicted)
form :powder
color :white to beige
Boiling point :769.3±70.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble25mg/mL, clear
pka :2.48±0.12(Predicted)
form :powder
color :white to beige
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
The p97 AAA (ATPase associated with diverse cellular activities) is a ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. Valosin-containing protein (VCP), also known as VCP/p97, is an AAA ATPase family member that serves as an integral component of the ubiquitin fusion degradation pathway and is overexpressed in many tumor types. NMS-873 is a VCP inhibitor (IC50 = 24 nM) that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM). It has been shown to inhibit the proliferation of HCT116 cancer cells with an IC50 value of 380 nM.Related product price
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