NVP-HSP990(HSP990)
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- $37 - $3734
- Product name: NVP-HSP990(HSP990)
- CAS: 934343-74-5
- MF: C20H18FN5O2
- MW: 379.39
- EINECS:
- MDL Number:MFCD22628859
- Synonyms:NVP-HSP990(HSP990);HSP-990;NVP-HSP990;(R)-2-Amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one;(7R)-2-amino-7-[4-fluoro-2-(6-methoxy-2-pyridinyl)phenyl]-7,8-dihydro-4-methyl-pyrido[4,3-d]pyrimidin-5(6H)-one;HSP990 (NVP-HSP990);(7R)-2-Amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydro-6H-pyrido[4,3-d;NVP-HSP990(HSP990) USP/EP/BP
22 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 10mM(in 1mL DMSO)
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number2608AH
- Product descriptionNVP-HSP990
- Packaging1g
- Price$3734
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4797
- Product descriptionHSP990(NVP-HSP990)
- Packaging5mg
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4797
- Product descriptionHSP990(NVP-HSP990)
- Packaging10mM(in 1mL DMSO)
- Price$116
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4797
- Product descriptionHSP990(NVP-HSP990)
- Packaging25mg
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4797
- Product descriptionHSP990(NVP-HSP990)
- Packaging100mg
- Price$700
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146192
- Product descriptionNVP-HSP990 (HSP990) >99%
- Packaging100mg
- Price$765
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146192
- Product descriptionNVP-HSP990 (HSP990) >99%
- Packaging250mg
- Price$1504.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146192
- Product descriptionNVP-HSP990 (HSP990) >99%
- Packaging1g
- Price$2986.9
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19149
- Product descriptionHSP-990 ≥98%
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19149
- Product descriptionHSP-990 ≥98%
- Packaging5mg
- Price$161
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19149
- Product descriptionHSP-990 ≥98%
- Packaging10mg
- Price$283
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19149
- Product descriptionHSP-990 ≥98%
- Packaging25mg
- Price$573
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-3941
- Product descriptionNVP-HSP990 99.47%
- Packaging5mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3941
- Product descriptionNVP-HSP990 99.47%
- Packaging10mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3941
- Product descriptionNVP-HSP990 99.47%
- Packaging25mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3941
- Product descriptionNVP-HSP990 99.47%
- Packaging50mg
- Price$420
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2608AH | NVP-HSP990 | 1g | $3734 | 2021-12-16 | Buy |
| ApexBio Technology | B4797 | HSP990(NVP-HSP990) | 5mg | $105 | 2021-12-16 | Buy |
| ApexBio Technology | B4797 | HSP990(NVP-HSP990) | 10mM(in 1mL DMSO) | $116 | 2021-12-16 | Buy |
| ApexBio Technology | B4797 | HSP990(NVP-HSP990) | 25mg | $330 | 2021-12-16 | Buy |
| ApexBio Technology | B4797 | HSP990(NVP-HSP990) | 100mg | $700 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146192 | NVP-HSP990 (HSP990) >99% | 100mg | $765 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146192 | NVP-HSP990 (HSP990) >99% | 250mg | $1504.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146192 | NVP-HSP990 (HSP990) >99% | 1g | $2986.9 | 2021-12-16 | Buy |
| Cayman Chemical | 19149 | HSP-990 ≥98% | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 19149 | HSP-990 ≥98% | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 19149 | HSP-990 ≥98% | 10mg | $283 | 2024-03-01 | Buy |
| Cayman Chemical | 19149 | HSP-990 ≥98% | 25mg | $573 | 2024-03-01 | Buy |
| ChemScene | CS-3941 | NVP-HSP990 99.47% | 5mg | $75 | 2021-12-16 | Buy |
| ChemScene | CS-3941 | NVP-HSP990 99.47% | 10mg | $125 | 2021-12-16 | Buy |
| ChemScene | CS-3941 | NVP-HSP990 99.47% | 25mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-3941 | NVP-HSP990 99.47% | 50mg | $420 | 2021-12-16 | Buy |
Properties
Density :1.332
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥12.3 mg/mL in DMSO
form :solid
color :Off-white to yellow
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥12.3 mg/mL in DMSO
form :solid
color :Off-white to yellow
Safety Information
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Description
The heat shock proteins (Hsps) act as molecular chaperones. Hsp90 is an abundant protein with roles in protein folding, cell signaling, and cancer. HSP-990 is an Hsp90 inhibitor with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and GRP94, respectively. It inhibits the TRAP1 ATPase with an IC50 value of 320 nM and demonstrates IC50 values of >5 μM in a panel of 51 unrelated kinases. In c-Met amplified GTL-16 gastric tumor cells, HSP-990 has been shown to dissociate the Hsp90-p23 complex, depleting the client protein c-Met and inducing Hsp70. HSP-990 can inhibit proliferation of various human tumor cell lines with GI50 values of 4-40 nM. Single oral administration of 15 mg/kg of HSP-990 was shown to induce sustained downregulation of c-Met and upregulation of Hsp70 in a GTL-16 xenograft model.Related product price
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