PACRITINIB
|
- $44 - $8950
- Product name: PACRITINIB
- CAS: 937272-79-2
- MF: C28H32N4O3
- MW: 472.58
- EINECS:
- MDL Number:MFCD22572772
- Synonyms:14,19-Dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene, 11-[2-(1-pyrrolidinyl)ethoxy]-, (16E)-;16E)-11-[2-(1-Pyrrolidinyl)ethoxy]-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene Pacritinib (SB1518);Pacritinib, >=98%;PACRITINIB;SB1518;Pacritinib (SB1518);(16E)-11-[2-(1-Pyrrolidinyl)ethoxy]-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene;SB1518(Pacritinib)
20 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
Package
- 500μg
- 1MG
- 2mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1000mg
- ManufacturerAK Scientific
- Product number2626AH
- Product descriptionPacritinib
- Packaging2mg
- Price$126
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0026041
- Product descriptionSB-1518 95.00%
- Packaging1MG
- Price$187.95
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0026041
- Product descriptionSB-1518 95.00%
- Packaging5MG
- Price$504.42
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181302
- Product descriptionPacritinib >98%
- Packaging100mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181302
- Product descriptionPacritinib >98%
- Packaging250mg
- Price$1654.1
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181302
- Product descriptionPacritinib >98%
- Packaging1000mg
- Price$3282.7
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16709
- Product descriptionPacritinib ≥98%
- Packaging500μg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16709
- Product descriptionPacritinib ≥98%
- Packaging1mg
- Price$84
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16709
- Product descriptionPacritinib ≥98%
- Packaging5mg
- Price$341
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-1741
- Product descriptionPacritinib 99.93%
- Packaging5mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1741
- Product descriptionPacritinib 99.93%
- Packaging10mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1741
- Product descriptionPacritinib 99.93%
- Packaging50mg
- Price$290
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1741
- Product descriptionPacritinib 99.93%
- Packaging100mg
- Price$490
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000170
- Product descriptionPacritinib 98+%
- Packaging10mg
- Price$276
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000170
- Product descriptionPacritinib 98+%
- Packaging25mg
- Price$648
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000170
- Product descriptionPacritinib 98+%
- Packaging50mg
- Price$1231
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2626AH | Pacritinib | 2mg | $126 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0026041 | SB-1518 95.00% | 1MG | $187.95 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0026041 | SB-1518 95.00% | 5MG | $504.42 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181302 | Pacritinib >98% | 100mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181302 | Pacritinib >98% | 250mg | $1654.1 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181302 | Pacritinib >98% | 1000mg | $3282.7 | 2021-12-16 | Buy |
| Cayman Chemical | 16709 | Pacritinib ≥98% | 500μg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 16709 | Pacritinib ≥98% | 1mg | $84 | 2024-03-01 | Buy |
| Cayman Chemical | 16709 | Pacritinib ≥98% | 5mg | $341 | 2024-03-01 | Buy |
| ChemScene | CS-1741 | Pacritinib 99.93% | 5mg | $70 | 2021-12-16 | Buy |
| ChemScene | CS-1741 | Pacritinib 99.93% | 10mg | $110 | 2021-12-16 | Buy |
| ChemScene | CS-1741 | Pacritinib 99.93% | 50mg | $290 | 2021-12-16 | Buy |
| ChemScene | CS-1741 | Pacritinib 99.93% | 100mg | $490 | 2021-12-16 | Buy |
| Crysdot | CD31000170 | Pacritinib 98+% | 10mg | $276 | 2021-12-16 | Buy |
| Crysdot | CD31000170 | Pacritinib 98+% | 25mg | $648 | 2021-12-16 | Buy |
| Crysdot | CD31000170 | Pacritinib 98+% | 50mg | $1231 | 2021-12-16 | Buy |
Properties
Boiling point :694.3±65.0 °C(Predicted)
Density :1.22±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:5.0(Max Conc. mg/mL);10.6(Max Conc. mM)
form :A crystalline solid
pka :9.56±0.20(Predicted)
color :Light yellow to yellow
Density :1.22±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:5.0(Max Conc. mg/mL);10.6(Max Conc. mM)
form :A crystalline solid
pka :9.56±0.20(Predicted)
color :Light yellow to yellow
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
FMS-like tyrosine kinase 3 (FLT3) and Janus kinase 2 (JAK2) are tyrosine kinases that mediate cytokine signaling and are frequently mutated in cancers, particularly acute myeloid leukemia. Pacritinib is an inhibitor of both FLT3 and JAK2 (IC50s = 22 and 23 nM, respectively). It also blocks the activities of the FLT3 D835Y mutant, FLT3 with internal tandem duplications (ITDs), and JAK2 with a V617F substitution (IC50s = 6, 20-180, and 220 nM, respectively). Pacritinib also inhibits JAK1, JAK3, and TYK2 (IC50s = 1280, 520, and 50 nM, respectively). Pacritinib is orally bioavailable, inhibiting FLT3 and JAK2 signaling, tumor growth, and metastasis in xenografts in mice. It is synergistic with the histone deacetylase inhibitor pracinostat (also known as SB 939, ), decreasing cell proliferation and inducing apoptosis in cells carrying either the JAK2 V617F mutation or FLT3 with ITDs, both in vitro and in vivo. Pacritinib has potential in resolving hematological malignancies.More related product prices
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