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ChemicalBook >> CAS DataBase List >> PLX647

PLX647

PLX647 price.
  • $60 - $850
  • Product name: PLX647
  • CAS: 873786-09-5
  • MF: C21H17F3N4
  • MW: 382.38
  • EINECS:
  • MDL Number:MFCD28100808
  • Synonyms:PLX647;PLC647;5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinamine;[5-[(1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-yl](4-trifluoromethylbenzyl)amine;2-Pyridinamine, 5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-;PLX 647;PLX-647;CS-1696;5-({1H-pyrrolo[2,3-b]pyridin-3-yl}methyl)-N-{[4-(trifluoromethyl)phenyl]methyl}pyridin-2-amine
18 prices
Selected condition:
Brand
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 5mg
  • 25mg
  • 100mg
  • 250mg
  • 10mg
  • 50mg
  • 10mM(in 1mL DMSO)
  • ManufacturerApexBio Technology
  • Product numberB5816
  • Product descriptionPLX647
  • Packaging10mM(in 1mL DMSO)
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5816
  • Product descriptionPLX647
  • Packaging10mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5816
  • Product descriptionPLX647
  • Packaging50mg
  • Price$580
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18012
  • Product descriptionPLX647 ≥95%
  • Packaging5mg
  • Price$97
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18012
  • Product descriptionPLX647 ≥95%
  • Packaging10mg
  • Price$184
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18012
  • Product descriptionPLX647 ≥95%
  • Packaging25mg
  • Price$433
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18012
  • Product descriptionPLX647 ≥95%
  • Packaging50mg
  • Price$768
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM149779
  • Product description5-((1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-(4-(trifluoromethyl)benzyl)pyridin-2-amine 95%+
  • Packaging50mg
  • Price$386
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3984
  • Product descriptionPLX647 99.07%
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3984
  • Product descriptionPLX647 99.07%
  • Packaging10mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3984
  • Product descriptionPLX647 99.07%
  • Packaging50mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3984
  • Product descriptionPLX647 99.07%
  • Packaging100mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31000464
  • Product descriptionPLX647 98+%
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31000464
  • Product descriptionPLX647 98+%
  • Packaging10mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31000464
  • Product descriptionPLX647 98+%
  • Packaging50mg
  • Price$413
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8107
  • Product descriptionPLX647 >98%
  • Packaging100mg
  • Price$500
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ApexBio Technology B5816 PLX647 10mM(in 1mL DMSO) $90 2021-12-16 Buy
ApexBio Technology B5816 PLX647 10mg $140 2021-12-16 Buy
ApexBio Technology B5816 PLX647 50mg $580 2021-12-16 Buy
Cayman Chemical 18012 PLX647 ≥95% 5mg $97 2024-03-01 Buy
Cayman Chemical 18012 PLX647 ≥95% 10mg $184 2024-03-01 Buy
Cayman Chemical 18012 PLX647 ≥95% 25mg $433 2024-03-01 Buy
Cayman Chemical 18012 PLX647 ≥95% 50mg $768 2024-03-01 Buy
Chemenu CM149779 5-((1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-(4-(trifluoromethyl)benzyl)pyridin-2-amine 95%+ 50mg $386 2021-12-16 Buy
ChemScene CS-3984 PLX647 99.07% 5mg $60 2021-12-16 Buy
ChemScene CS-3984 PLX647 99.07% 10mg $90 2021-12-16 Buy
ChemScene CS-3984 PLX647 99.07% 50mg $250 2021-12-16 Buy
ChemScene CS-3984 PLX647 99.07% 100mg $450 2021-12-16 Buy
Crysdot CD31000464 PLX647 98+% 5mg $60 2021-12-16 Buy
Crysdot CD31000464 PLX647 98+% 10mg $105 2021-12-16 Buy
Crysdot CD31000464 PLX647 98+% 50mg $413 2021-12-16 Buy
DC Chemicals DC8107 PLX647 >98% 100mg $500 2021-12-16 Buy

Properties

Density :1.358±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :13.73±0.40(Predicted)
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

PLX647 is a dual inhibitor of the receptor tyrosine kinases FMS and KIT (IC50s = 28 and 16 nM, respectively). It is selective for FMS and KIT but does inhibit FLT3 and KDR (IC50s = 91 and 130 nM, respectively) in a panel of 400 kinases at a concentration of 1 μM. PLX647 inhibits proliferation of Ba/F3 cells expressing constitutively active FMS or KIT (IC50s = 92 and 180 nM, respectively) as well as ligand-dependent growth of M-NFS-60 and M-07e cells that express endogenous FMS and KIT, respectively (IC50s = 380 and 230 nM, respectively). It has no effect on HEK293T or HepG2 cells that lack FMS and KIT (IC50 = >50 μM) or Ba/F3 cells overexpressing KDR (IC50 = >5 μM). PLX647 also inhibits differentiation of human osteoclast precursor cells (IC50 = 170 nM). In vivo, PLX647 (40 mg/kg) reduces TNF-α and IL-6 release in a rat model of LPS-induced cytokine release. It reduces mast cell degranulation in a mouse model of passive cutaneous anaphylaxis (PCA) and inhibits bone destruction and delays disease progression in a mouse model of collagen-induced arthritis (CIA). PLX647 also reverses bone osteolysis and allodynia in a syngeneic rat model of cancer-induced bone pain.

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