Prucalopride
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- $11 - $1802
- Product name: Prucalopride
- CAS: 179474-81-8
- MF: C18H26ClN3O3
- MW: 367.87
- EINECS:1312995-182-4
- MDL Number:MFCD09837787
- Synonyms:Prucalopride;4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide;4-Amino-5-chloro-2,3-dihydro-N-(1-(3-methoxypropyl)-4-piperidyl)-7-benzofurancarboxamide;R 093877;R093877;Resolor;Unii-0A09iuw5tp;Prucalopride(R-93877)
39 prices
Selected condition:
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
Package
- 1unit
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 10mM(in 1mL DMSO)
- 1g
- 5g
- 10g
- 25g
- ManufacturerAK Scientific
- Product numberY0251
- Product descriptionPrucalopride
- Packaging25mg
- Price$116
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ93045
- Product descriptionPrucalopride
- Packaging250mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA126651
- Product descriptionPrucalopride 98+%
- Packaging5mg
- Price$11
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA126651
- Product descriptionPrucalopride 98+%
- Packaging10mg
- Price$14
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA126651
- Product descriptionPrucalopride 98+%
- Packaging50mg
- Price$25
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA126651
- Product descriptionPrucalopride 98+%
- Packaging100mg
- Price$48
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA126651
- Product descriptionPrucalopride 98+%
- Packaging250mg
- Price$94
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA126651
- Product descriptionPrucalopride 98+%
- Packaging1g
- Price$231
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberBRS0000671
- Product descriptionPRUCALOPRIDE 95.00%
- Packaging5MG
- Price$424
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberBRS0000671
- Product descriptionPRUCALOPRIDE 95.00%
- Packaging10MG
- Price$448
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2253
- Product descriptionPrucalopride
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2253
- Product descriptionPrucalopride
- Packaging10mM(in 1mL DMSO)
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2253
- Product descriptionPrucalopride
- Packaging10mg
- Price$63
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2253
- Product descriptionPrucalopride
- Packaging50mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180793
- Product descriptionPrucalopride >99%
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180793
- Product descriptionPrucalopride >99%
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | Y0251 | Prucalopride | 25mg | $116 | 2021-12-16 | Buy |
AK Scientific | J93045 | Prucalopride | 250mg | $250 | 2021-12-16 | Buy |
Ambeed | A126651 | Prucalopride 98+% | 5mg | $11 | 2021-12-16 | Buy |
Ambeed | A126651 | Prucalopride 98+% | 10mg | $14 | 2021-12-16 | Buy |
Ambeed | A126651 | Prucalopride 98+% | 50mg | $25 | 2021-12-16 | Buy |
Ambeed | A126651 | Prucalopride 98+% | 100mg | $48 | 2021-12-16 | Buy |
Ambeed | A126651 | Prucalopride 98+% | 250mg | $94 | 2021-12-16 | Buy |
Ambeed | A126651 | Prucalopride 98+% | 1g | $231 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | BRS0000671 | PRUCALOPRIDE 95.00% | 5MG | $424 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | BRS0000671 | PRUCALOPRIDE 95.00% | 10MG | $448 | 2021-12-16 | Buy |
ApexBio Technology | B2253 | Prucalopride | 1unit | $28 | 2021-12-16 | Buy |
ApexBio Technology | B2253 | Prucalopride | 10mM(in 1mL DMSO) | $55 | 2021-12-16 | Buy |
ApexBio Technology | B2253 | Prucalopride | 10mg | $63 | 2021-12-16 | Buy |
ApexBio Technology | B2253 | Prucalopride | 50mg | $200 | 2021-12-16 | Buy |
Biorbyt Ltd | orb180793 | Prucalopride >99% | 100mg | $606.9 | 2021-12-16 | Buy |
Biorbyt Ltd | orb180793 | Prucalopride >99% | 250mg | $912.9 | 2021-12-16 | Buy |
Properties
Melting point :90.7°
Boiling point :481.4±45.0 °C(Predicted)
Density :1.28
storage temp. :2-8°C
solubility :DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml
pka :13.65±0.20(Predicted)
form :powder
color :white to beige
InChI :InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
InChIKey :ZPMNHBXQOOVQJL-UHFFFAOYSA-N
SMILES :O1C2=C(C(NC3CCN(CCCOC)CC3)=O)C=C(Cl)C(N)=C2CC1
Boiling point :481.4±45.0 °C(Predicted)
Density :1.28
storage temp. :2-8°C
solubility :DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml
pka :13.65±0.20(Predicted)
form :powder
color :white to beige
InChI :InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
InChIKey :ZPMNHBXQOOVQJL-UHFFFAOYSA-N
SMILES :O1C2=C(C(NC3CCN(CCCOC)CC3)=O)C=C(Cl)C(N)=C2CC1
Safety Information
Symbol(GHS): |
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Description
Prucalopride is a potent and selective agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Kis = 2.5 and 8 nM for human 5-HT4A and 5-HT4B, respectively). Prucalopride is greater than 250-fold selective for 5-HT4 over a panel of 53 overexpressed receptors, including 5-HT subtypes, but does bind to human dopamine D4 and sigma-1 (σ1) receptors and mouse 5-HT3 receptors (Kis = 2.3, 3.7, and 3.8 μM, respectively). It induces contractions in guinea pig colon with an EC50 value of 33 nM, an effect that is blocked by the 5-HT4 antagonist GR113808 but not the 5-HT2A and 5-HT3 antagonists ketanserin and granisetron , respectively. It also facilitates non-cholinergic contractions induced by electrical stimulation. In fasted dogs, oral administration of prucalopride increases colonic motility by inhibiting distal colon contractions (ED50 = 0.04 mg/kg), an effect that is blocked by pretreatment with the 5-HT4 antagonist GR125487. Prucalopride (5-10 mg/kg, s.c.) increases acetylcholine and histamine levels in the rat prefrontal cortex by 2.4-fold and 3-fold, respectively, and increases the power of hippocampal theta oscillations. Formulations containing prucalopride have been used in the treatment of chronic idiopathic constipation.More related product prices
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