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ChemicalBook >> CAS DataBase List >> SC-514

SC-514

SC-514 price.
  • $24 - $1802
  • Product name: SC-514
  • CAS: 354812-17-2
  • MF: C9H8N2OS2
  • MW: 224.3
  • EINECS:
  • MDL Number:MFCD00206459
  • Synonyms:SC-514, >=98%;3-amino-5-(thiophen-3-yl)thiophene-2-carboxamide;SC-514;GK 01140;IKK-2 Inhibitor, SC-514 ;4-Amino-[2',3'-bithiophene]-5-carboxamide;SC-514;5-(Thien-3-yl)-3-aminothiophene-2-carboxamide;GK 01140
43 prices
Selected condition:
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 50
  • 1mg
  • 5mg
  • 10
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 10mM(in 1mL DMSO)
  • 1000mg
  • ManufacturerAK Scientific
  • Product numberSYN5279
  • Product descriptionSC-514
  • Packaging10mg
  • Price$86
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN5279
  • Product descriptionSC-514
  • Packaging50mg
  • Price$266
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA499215
  • Product descriptionSC514 98+%
  • Packaging5mg
  • Price$24
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA499215
  • Product descriptionSC514 98+%
  • Packaging10mg
  • Price$33
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA499215
  • Product descriptionSC514 98+%
  • Packaging50mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA499215
  • Product descriptionSC514 98+%
  • Packaging100mg
  • Price$88
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA499215
  • Product descriptionSC514 98+%
  • Packaging250mg
  • Price$176
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA499215
  • Product descriptionSC514 98+%
  • Packaging1g
  • Price$438
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000534
  • Product descriptionSC-514 95.00%
  • Packaging5MG
  • Price$455
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000534
  • Product descriptionSC-514 95.00%
  • Packaging10MG
  • Price$704.55
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000534
  • Product descriptionSC-514 95.00%
  • Packaging100MG
  • Price$1593.9
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1585
  • Product descriptionSC-514
  • Packaging10mM(in 1mL DMSO)
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS577703
  • Product descriptionSC514 ≥98%
  • Packaging5mg
  • Price$24
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS577703
  • Product descriptionSC514 ≥98%
  • Packaging10mg
  • Price$33
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS577703
  • Product descriptionSC514 ≥98%
  • Packaging50mg
  • Price$54
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS577703
  • Product descriptionSC514 ≥98%
  • Packaging100mg
  • Price$87
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5279 SC-514 10mg $86 2021-12-16 Buy
AK Scientific SYN5279 SC-514 50mg $266 2021-12-16 Buy
Ambeed A499215 SC514 98+% 5mg $24 2021-12-16 Buy
Ambeed A499215 SC514 98+% 10mg $33 2021-12-16 Buy
Ambeed A499215 SC514 98+% 50mg $55 2021-12-16 Buy
Ambeed A499215 SC514 98+% 100mg $88 2021-12-16 Buy
Ambeed A499215 SC514 98+% 250mg $176 2021-12-16 Buy
Ambeed A499215 SC514 98+% 1g $438 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000534 SC-514 95.00% 5MG $455 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000534 SC-514 95.00% 10MG $704.55 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000534 SC-514 95.00% 100MG $1593.9 2021-12-16 Buy
ApexBio Technology B1585 SC-514 10mM(in 1mL DMSO) $65 2021-12-16 Buy
Arctom AS577703 SC514 ≥98% 5mg $24 2021-12-16 Buy
Arctom AS577703 SC514 ≥98% 10mg $33 2021-12-16 Buy
Arctom AS577703 SC514 ≥98% 50mg $54 2021-12-16 Buy
Arctom AS577703 SC514 ≥98% 100mg $87 2021-12-16 Buy

Properties

Melting point :209-211°C
Boiling point :399.2±42.0 °C(Predicted)
Density :1.450±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :15.63±0.50(Predicted)
form :powder
color :white to light brown
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SC-514 is a selective and reversible inhibitor of IKKβ (IKK-2) (IC50 = 3-12 μM) that displays >10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK. This compound attenuates NF-κB-induced gene expression of IL-6, IL-8 and Cox-2 (IC50 = 20, 20, and 8 μM, respectively). Improper activation of NF-κB has been linked to cancer, immune and inflammatory diseases, and viral infection.

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