SUFUGOLIX
- $36 - $943.91
- Product name: SUFUGOLIX
- CAS: 308831-61-0
- MF: C36H31F2N5O4S
- MW: 667.72
- EINECS:
- MDL Number:MFCD09837896
- Synonyms:SUFUGOLIX;TAK013;N-(4-(5-((benzyl(methyl)amino)methyl)-1-(2,6-difluorobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl)phenyl)-N'-methoxyurea;TAK013;TAK 013;Sufugolix(TAK-013);SUFUGOLIX, >98%;tak-013, >98%;Urea, N-[4-[1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro-5-[[methyl(phenylmethyl)amino]methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-N'-methoxy-
5 prices
Selected condition:
Brand
- AK Scientific
- American Custom Chemicals Corporation
- Cayman Chemical
Package
- 1mg
- 5mg
- 10mg
- ManufacturerAK Scientific
- Product number6280CJ
- Product descriptionSufugolix
- Packaging5mg
- Price$260
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberBRS0000770
- Product descriptionTAK-013 95.00%
- Packaging5MG
- Price$943.91
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number27996
- Product descriptionSufugolix
- Packaging1mg
- Price$36
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27996
- Product descriptionSufugolix
- Packaging5mg
- Price$145
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27996
- Product descriptionSufugolix
- Packaging10mg
- Price$223
- Updated2024-03-01
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | 6280CJ | Sufugolix | 5mg | $260 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | BRS0000770 | TAK-013 95.00% | 5MG | $943.91 | 2021-12-16 | Buy |
Cayman Chemical | 27996 | Sufugolix | 1mg | $36 | 2024-03-01 | Buy |
Cayman Chemical | 27996 | Sufugolix | 5mg | $145 | 2024-03-01 | Buy |
Cayman Chemical | 27996 | Sufugolix | 10mg | $223 | 2024-03-01 | Buy |
Properties
Density :1.383±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C,unstable in solution, ready to use.
solubility :DMF: 5mg/mL; DMF:PBS (pH 7.2) (1:2): 0.3mg/mL; DMSO: 3mg/mL
form :A solid
pka :13.20±0.70(Predicted)
color :Light yellow to yellow
storage temp. :Store at -20°C,unstable in solution, ready to use.
solubility :DMF: 5mg/mL; DMF:PBS (pH 7.2) (1:2): 0.3mg/mL; DMSO: 3mg/mL
form :A solid
pka :13.20±0.70(Predicted)
color :Light yellow to yellow
Safety Information
Symbol(GHS): | |||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Warning | ||||||||||||||||||||||||||||||
Hazard statements: |
|
||||||||||||||||||||||||||||||
Precautionary statements: |
|
Description
Sufugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist (IC50 = 0.1 nM). Sufugolix inhibits GnRH-induced arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) release in CHO cells expressing human recombinant or monkey recombinant GnRH (IC50s = 0.1 and 10 nM, respectively), but not the rat GnRH receptor. It inhibits luteinizing hormone (LH) release stimulated by GnRH in monkey pituitary cells ex vivo (IC50 = 36 nM). Sufugolix (10 and 30 mg/kg) reduces increases in plasma LH following castration in male cynomolgus monkeys and lowers serum LH, estradiol, and progesterone levels in female cynomolgus monkeys when administered at a dose of 90 mg/kg.Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Alfa Chemistry
InvivoChem
Nantong HI-FUTURE Biology Co., Ltd.
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Wuhan Jingkang en Biomedical Technology Co., Ltd