SirReal2
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- $37 - $900
- Product name: SirReal2
- CAS: 709002-46-0
- MF: C22H20N4OS2
- MW: 420.55
- EINECS:
- MDL Number:MFCD04173051
- Synonyms:SirReal2;Acetamide,2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]-;2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide;2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide;SirReal2 >=98% (HPLC);Sirtuin,Inhibitor,inhibit,SirReal2,SirReal 2,SirReal-2;2-((4,6-Dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide
16 prices
Selected condition：
Brand
- AK Scientific
- Axon Medchem
- Cayman Chemical
- ChemScene
- CSNpharm
- DC Chemicals
- Tocris
- TRC
- Usbiological
Package
- 50
- 5mg
- 1mg
- 10
- 2x5mg
- 10mg
- 50mg
- 100mg
- 250mg
- ManufacturerAK Scientific
- Product number4698CE
- Product description2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide
- Packaging10mg
- Price$336
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2453
- Product descriptionSirReal2 98%
- Packaging2x5mg
- Price$165
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18116
- Product descriptionSirReal2 ≥98%
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18116
- Product descriptionSirReal2 ≥98%
- Packaging5mg
- Price$116
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18116
- Product descriptionSirReal2 ≥98%
- Packaging10mg
- Price$178
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18116
- Product descriptionSirReal2 ≥98%
- Packaging50mg
- Price$793
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0019744
- Product descriptionSirReal2 >99.0%
- Packaging5mg
- Price$375
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0019744
- Product descriptionSirReal2 >99.0%
- Packaging10mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN19216
- Product descriptionSirReal2
- Packaging5mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN19216
- Product descriptionSirReal2
- Packaging10mg
- Price$605
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8867
- Product descriptionSirReal2 >98%
- Packaging100mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8867
- Product descriptionSirReal2 >98%
- Packaging250mg
- Price$900
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number5457
- Product descriptionSirReal2 ≥98%(HPLC)
- Packaging10
- Price$161
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number5457
- Product descriptionSirReal2 ≥98%(HPLC)
- Packaging50
- Price$664
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberS490925
- Product descriptionSirReal2
- Packaging50mg
- Price$690
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number256672
- Product descriptionSirReal 2
- Packaging10mg
- Price$475
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4698CE | 2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide | 10mg | $336 | 2021-12-16 | Buy |
| Axon Medchem | Axon2453 | SirReal2 98% | 2x5mg | $165 | 2021-12-16 | Buy |
| Cayman Chemical | 18116 | SirReal2 ≥98% | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 18116 | SirReal2 ≥98% | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 18116 | SirReal2 ≥98% | 10mg | $178 | 2024-03-01 | Buy |
| Cayman Chemical | 18116 | SirReal2 ≥98% | 50mg | $793 | 2024-03-01 | Buy |
| ChemScene | CS-0019744 | SirReal2 >99.0% | 5mg | $375 | 2021-12-16 | Buy |
| ChemScene | CS-0019744 | SirReal2 >99.0% | 10mg | $650 | 2021-12-16 | Buy |
| CSNpharm | CSN19216 | SirReal2 | 5mg | $350 | 2021-12-16 | Buy |
| CSNpharm | CSN19216 | SirReal2 | 10mg | $605 | 2021-12-16 | Buy |
| DC Chemicals | DC8867 | SirReal2 >98% | 100mg | $500 | 2021-12-16 | Buy |
| DC Chemicals | DC8867 | SirReal2 >98% | 250mg | $900 | 2021-12-16 | Buy |
| Tocris | 5457 | SirReal2 ≥98%(HPLC) | 10 | $161 | 2021-12-16 | Buy |
| Tocris | 5457 | SirReal2 ≥98%(HPLC) | 50 | $664 | 2021-12-16 | Buy |
| TRC | S490925 | SirReal2 | 50mg | $690 | 2021-12-16 | Buy |
| Usbiological | 256672 | SirReal 2 | 10mg | $475 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMSO: 3 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
form :A crystalline solid
color :Off-white to light yellow
solubility :DMSO: 3 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
form :A crystalline solid
color :Off-white to light yellow
Safety Information
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Description
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). SIRT2 deacetylates histone H4 and α-tubulin and functions as a regulator of cell cycle progression, a determinant of myelination, a modulator of autophagy, and a suppressor of brain inflammation. SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM). SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6. This compound has been shown to be active in HeLa cells by significantly increasing α-tubulin acetylation.Related product price
- 2-Amino-4,6-dimethylpyrimidine
$5-860 - Acetamide
$13-950