UCF-101
- $36 - $1300
- Product name: UCF-101
- CAS: 313649-08-0
- MF: C27H17N3O5S
- MW: 495.51
- EINECS:
- MDL Number:MFCD01000361
- Synonyms:Dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione;UCF-101;HIGH TEMPERATURE REQUIREMENT A2 INHIBITOR I;5-[5-(2-NITROPHENYL)FURFURYLIDINE]-1,3-DIPHENYL-2-THIOBARBITURIC ACID;5-[[5-(2-nitrophenyl)furan-2-yl]methylidene]-1,3-diphenyl-2-sulfanylidene-1,3-diazinane-4,6-dione;Omi/HtrA2 Protease Inhibitor, Ucf-101 - CAS 313649-08-0 - Calbiochem;5-[[5-[2-(dihydroxyamino)phenyl]furan-2-yl]methylidene]-1,3-diphenyl-2-sulfanylidene-1,3-diazinane-4,6-dione;4,6(1H,5H)-Pyrimidinedione, dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-
11 prices
Selected condition:
Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5MG
- 10mg
- 25mg
- 100mg
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM1034489
- Product description5-[5-(2-NITROPHENYL)FURFURYLIDINE]-1,3-DIPHENYL-2-THIOBARBITURIC ACID 95.00%
- Packaging5MG
- Price$496.66
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4437
- Product descriptionUCF101
- Packaging5mg
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15550
- Product descriptionUCF 101 ≥98%
- Packaging1mg
- Price$36
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15550
- Product descriptionUCF 101 ≥98%
- Packaging5mg
- Price$78
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15550
- Product descriptionUCF 101 ≥98%
- Packaging10mg
- Price$138
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15550
- Product descriptionUCF 101 ≥98%
- Packaging25mg
- Price$299
- Updated2024-03-01
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number62519
- Product descriptionUCF101
- Packaging10mg
- Price$625
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number62519
- Product descriptionUCF101
- Packaging100mg
- Price$1300
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML1105
- Product descriptionUCF-101 ≥98% (HPLC)
- Packaging5mg
- Price$120
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML1105
- Product descriptionUCF-101 ≥98% (HPLC)
- Packaging25mg
- Price$476
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberU130500
- Product descriptionUCF101
- Packaging5mg
- Price$65
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
American Custom Chemicals Corporation | CHM1034489 | 5-[5-(2-NITROPHENYL)FURFURYLIDINE]-1,3-DIPHENYL-2-THIOBARBITURIC ACID 95.00% | 5MG | $496.66 | 2021-12-16 | Buy |
ApexBio Technology | C4437 | UCF101 | 5mg | $96 | 2021-12-16 | Buy |
Cayman Chemical | 15550 | UCF 101 ≥98% | 1mg | $36 | 2024-03-01 | Buy |
Cayman Chemical | 15550 | UCF 101 ≥98% | 5mg | $78 | 2024-03-01 | Buy |
Cayman Chemical | 15550 | UCF 101 ≥98% | 10mg | $138 | 2024-03-01 | Buy |
Cayman Chemical | 15550 | UCF 101 ≥98% | 25mg | $299 | 2024-03-01 | Buy |
Medical Isotopes, Inc. | 62519 | UCF101 | 10mg | $625 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | 62519 | UCF101 | 100mg | $1300 | 2021-12-16 | Buy |
Sigma-Aldrich | SML1105 | UCF-101 ≥98% (HPLC) | 5mg | $120 | 2024-03-01 | Buy |
Sigma-Aldrich | SML1105 | UCF-101 ≥98% (HPLC) | 25mg | $476 | 2024-03-01 | Buy |
TRC | U130500 | UCF101 | 5mg | $65 | 2021-12-16 | Buy |
Properties
Boiling point :651.8±65.0 °C(Predicted)
Density :1.50±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :-0.92±0.20(Predicted)
form :powder
color :light orange to dark orange
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
Density :1.50±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :-0.92±0.20(Predicted)
form :powder
color :light orange to dark orange
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
Safety Information
Symbol(GHS): | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Danger | ||||||||||||||||
Hazard statements: |
|
||||||||||||||||
Precautionary statements: |
|
Description
Mammalian Omi/HtrA2 is a serine protease localized in mitochondria with close homology to bacterial HtrA chaperones. It is released from the mitochondria in response to apoptotic stimuli whereupon it induces cell death through both a caspase-dependent manner and a mechanism that involves its protease activity. UCF 101 is an inhibitor of the proteolytic activity of Omi/HtrA2 (IC50 = 9.5 μM). It is highly specific for Omi/HtrA2, demonstrating less potent activity when tested against a panel of various other serine proteases (IC50s range from 200 to >500 μM). Additionally, UCF 101 is naturally fluorescent, thus enabling the visualization of its entry into cells. UCF 101 has been used to decrease cerebral infarct size in a rat model of cerebral ischemia, demonstrating neuroprotective effects by reducing apoptosis of cortical cells. It has also been reported to be protective of cardiomyocytes against ischemic injury through a mechanism that prevents Omi/HtrA2 proteolysis of Thanatos-associated protein 5, a cardiac-specific nuclear protein that controls cell cycle progression.Related product price
- ANTIBIOTIC UCN-02
$299-1432 - FCCP
$43-1575 - PUROMYCIN DIHYDROCHLORIDE
$11-5076
Suppliers and manufacturers
TargetMol Chemicals Inc.
Wuhan Topule Biopharmaceutical Co., Ltd
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
J & K SCIENTIFIC LTD.
Shanghai Lollane Biological Technology Co.,Ltd.
BOC Sciences
Shanghai EFE Biological Technology Co., Ltd.