WYE 354-d3
|
- $1760
- Product name: WYE 354-d3
- CAS: 1794791-66-4
- MF: C24H29N7O5
- MW: 495.54
- EINECS:
- MDL Number:
- Synonyms:WYE 354-d3;4-[6-[4-[[(Methoxy-d3)carbonyl]aMino]phenyl]-4-(4-Morpholinyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-1-piperidinecarboxylic Acid Methyl Ester
1 prices
Selected condition：
Brand
- TRC
Package
- 10mg
- ManufacturerTRC
- Product numberW950002
- Product descriptionWYE354-d3
- Packaging10mg
- Price$1760
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TRC | W950002 | WYE354-d3 | 10mg | $1760 | 2021-12-16 | Buy |
Properties
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
A labelled pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 μM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo.Related product price
- WYE-687
$48-4462.92 - N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea
$37-4462.92 - WYE-354
$36-1963.5