XL765
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- $31 - $1725
- Product name: XL765
- CAS: 1349796-36-6
- MF: C31H29N5O6S
- MW: 599.66
- EINECS:
- MDL Number:MFCD18252649
- Synonyms:SAR245409 (XL765);PI3K-IN-1;N-[4-[[[3-[(3,5-Dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methylbenzamide;Benzamide, N-[4-[[[3-[(3,5-dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methyl-;Voxtalisib (SAR245409, XL765);N-[4-[[[3-[(3,5-Dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methylbenzamide SAR245409 (XL765);XL765 N-[4-[[[3-[(3,5-Dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methylbenzamide;N-(4-(N-(3-((3,5-Dimethoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-3-methoxy-4-methylben
30 prices
Selected condition:
Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- ApexBio Technology
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 10mM(in 1mL DMSO)
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1137-M001
- Product descriptionXL765 ≥95%
- Packaging1mg
- Price$135
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1137-M005
- Product descriptionXL765 ≥95%
- Packaging5mg
- Price$227
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1137-M010
- Product descriptionXL765 ≥95%
- Packaging10mg
- Price$346
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1137
- Product descriptionXL765
- Packaging50mg
- Price$1065
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1137
- Product descriptionXL765
- Packaging100mg
- Price$1725
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA781923
- Product descriptionXL765Analogue 98+%
- Packaging2mg
- Price$31
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA781923
- Product descriptionXL765Analogue 98+%
- Packaging10mg
- Price$68
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA781923
- Product descriptionXL765Analogue 98+%
- Packaging50mg
- Price$198
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA781923
- Product descriptionXL765Analogue 98+%
- Packaging100mg
- Price$258
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5634
- Product descriptionSAR245409(XL765)
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5634
- Product descriptionSAR245409(XL765)
- Packaging10mM(in 1mL DMSO)
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5634
- Product descriptionSAR245409(XL765)
- Packaging25mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5634
- Product descriptionSAR245409(XL765)
- Packaging100mg
- Price$980
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16299
- Product descriptionXL765 ≥95%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16299
- Product descriptionXL765 ≥95%
- Packaging5mg
- Price$193
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16299
- Product descriptionXL765 ≥95%
- Packaging10mg
- Price$363
- Updated2024-03-01
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Adipogen Life Sciences | SYN-1137-M001 | XL765 ≥95% | 1mg | $135 | 2021-12-16 | Buy |
Adipogen Life Sciences | SYN-1137-M005 | XL765 ≥95% | 5mg | $227 | 2021-12-16 | Buy |
Adipogen Life Sciences | SYN-1137-M010 | XL765 ≥95% | 10mg | $346 | 2021-12-16 | Buy |
AK Scientific | SYN1137 | XL765 | 50mg | $1065 | 2021-12-16 | Buy |
AK Scientific | SYN1137 | XL765 | 100mg | $1725 | 2021-12-16 | Buy |
Ambeed | A781923 | XL765Analogue 98+% | 2mg | $31 | 2021-12-16 | Buy |
Ambeed | A781923 | XL765Analogue 98+% | 10mg | $68 | 2021-12-16 | Buy |
Ambeed | A781923 | XL765Analogue 98+% | 50mg | $198 | 2021-12-16 | Buy |
Ambeed | A781923 | XL765Analogue 98+% | 100mg | $258 | 2021-12-16 | Buy |
ApexBio Technology | A5634 | SAR245409(XL765) | 5mg | $120 | 2021-12-16 | Buy |
ApexBio Technology | A5634 | SAR245409(XL765) | 10mM(in 1mL DMSO) | $150 | 2021-12-16 | Buy |
ApexBio Technology | A5634 | SAR245409(XL765) | 25mg | $350 | 2021-12-16 | Buy |
ApexBio Technology | A5634 | SAR245409(XL765) | 100mg | $980 | 2021-12-16 | Buy |
Cayman Chemical | 16299 | XL765 ≥95% | 1mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 16299 | XL765 ≥95% | 5mg | $193 | 2024-03-01 | Buy |
Cayman Chemical | 16299 | XL765 ≥95% | 10mg | $363 | 2024-03-01 | Buy |
Properties
Density :1.387±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥15 mg/mL in DMSO
form :solid
pka :5.88±0.30(Predicted)
color :Light yellow to yellow
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥15 mg/mL in DMSO
form :solid
pka :5.88±0.30(Predicted)
color :Light yellow to yellow
Safety Information
Symbol(GHS): |
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Description
Phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) constitutively signal and drive cell survival and proliferation in many forms of cancer. XL765 is a dual inhibitor of both PI3K and mTOR, completely blocking phosphorylation of substrates at 8-16 μM. Similarly, XL765 is cytotoxic to glioblastoma multiforme (GBM) xenografts in vitro, with half maximal inhibition occurring at 3.7-7.7 μM. XL765 is orally bioavailable and passes the blood-brain barrier, reducing the growth of intracranial GBM xenografts in mice. This inhibitor is effective alone or in combination therapy with other compounds in various types of cancer.Related product price
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