Zaragozic acid A
|
- $194 - $637
- Product name: Zaragozic acid A
- CAS: 142561-96-4
- MF: C35H46O14
- MW: 690.73
- EINECS:
- MDL Number:MFCD00868072
- Synonyms:Squalestatin 1;Aids111671;Aids-111671;Gr 105155x;L-Erythro-L-glycero-D-altro-7-trideculo-7,4-furanosonic acid, 2,7-anhydro-3,4-di-C-carboxy-8,9,10,12,13-pentadeoxy-10-methylene-12-(phenylmethyl)-, 11-acetate 5-[(2E,4S,6S)-4,6-dimethyl-2-octenoate], (7S)-;Squalestatin A, Squalestatin S1, L 694599;ZARAGOZIC ACID A;DFKDOZMCHOGOBR-NCSQYGPNSA-N
5 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Cayman Chemical
- TRC
Package
- 0.5mg
- 1mg
- 5mg
- ManufacturerAK Scientific
- Product number8496CP
- Product descriptionZaragozicacidA
- Packaging5mg
- Price$637
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1624
- Product descriptionZaragozicAcidA
- Packaging5mg
- Price$549
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17452
- Product descriptionZaragozic Acid A ≥98%
- Packaging1mg
- Price$194
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17452
- Product descriptionZaragozic Acid A ≥98%
- Packaging5mg
- Price$483
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberZ150605
- Product descriptionZaragozicAcidA
- Packaging0.5mg
- Price$395
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 8496CP | ZaragozicacidA | 5mg | $637 | 2021-12-16 | Buy |
| ApexBio Technology | A1624 | ZaragozicAcidA | 5mg | $549 | 2021-12-16 | Buy |
| Cayman Chemical | 17452 | Zaragozic Acid A ≥98% | 1mg | $194 | 2024-03-01 | Buy |
| Cayman Chemical | 17452 | Zaragozic Acid A ≥98% | 5mg | $483 | 2024-03-01 | Buy |
| TRC | Z150605 | ZaragozicAcidA | 0.5mg | $395 | 2021-12-16 | Buy |
Properties
alpha :D22 +18.3° (c = 0.60 in CHCl3); D25 +37° (c = 1.29 in methanol)
Boiling point :850.1±65.0 °C(Predicted)
Density :1.35±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :Soluble in DMSO
form :solid
pka :1.47±0.70(Predicted)
color :white to light tan
CAS DataBase Reference :142561-96-4
Boiling point :850.1±65.0 °C(Predicted)
Density :1.35±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :Soluble in DMSO
form :solid
pka :1.47±0.70(Predicted)
color :white to light tan
CAS DataBase Reference :142561-96-4
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
Squalene synthase catalyzes the first committed step in cholesterol synthesis, mediating the reductive dimerization of farnesyl pyrophosphate to produce squalene. Zaragozic acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase (Ki = 78 pM in vitro). It dose-dependently reduces cholesterol synthesis in HepG2 cells (IC50 = 6 μM) and inhibits hepatic cholesterol synthesis in mice (ED50 = 0.2 mg/kg). Zaragozic acid A also inhibits farnesyl-protein transferase and geranylgeranyl-protein transferase type I (IC50s = 216 and 50 nM, respectively).Related product price
- SQUALESTATIN
$470-1036.09 - 5,5-DIETHOXYPENTAN-1-OL
$125.1-2000 - Hydroxycitric acid
$166-6730.15