Ziprasidone
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- $35 - $1000
- Product name: Ziprasidone
- CAS: 122883-93-6
- MF: C21H21ClN4OS
- MW: 412.943
- EINECS:602-903-0
- MDL Number:MFCD06795476
- Synonyms:5-(2-(4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one hydrochloride;5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride;5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one hydrochloride;5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-oxindole hydrochloride;2H-Indol-2-one,5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-,hydrochloride (1:1);5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-2,3-dihydro-1H-indol-2-one hydrochloride;CP 88059 hydrochloride;CP88059 hydrochloride
14 prices
Selected condition:
Brand
- AK Scientific
- ApexBio Technology
- AvaChem
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
Package
- 25mg
- 100mg
- 10mM(in 1mL DMSO)
- 1ML
- 1g
- 5g
- 10g
- ManufacturerAK Scientific
- Product numberH485
- Product descriptionZiprasidone hydrochloride
- Packaging25mg
- Price$38
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX9542
- Product descriptionZiprasidone hydrochloride
- Packaging1g
- Price$48
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5350
- Product descriptionZiprasidoneHCl
- Packaging10mM(in 1mL DMSO)
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5350
- Product descriptionZiprasidoneHCl
- Packaging100mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3107
- Product descriptionZiprasidone Hydrochloride
- Packaging100mg
- Price$35
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3107
- Product descriptionZiprasidone Hydrochloride
- Packaging1g
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3107
- Product descriptionZiprasidone Hydrochloride
- Packaging10g
- Price$245
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004184
- Product descriptionZiprasidone hydrochloride 98+%
- Packaging10g
- Price$146
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDCAPI1039
- Product descriptionZiprasidoneHCl >99%
- Packaging100mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDCAPI1039
- Product descriptionZiprasidoneHCl >99%
- Packaging1g
- Price$1000
- Updated2021-12-16
- Buy
- ManufacturerMatrix Scientific
- Product number074021
- Product description5-(2-(4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl)-ethyl)-6-chloroindolin-2-one hydrochloride 95+%
- Packaging10g
- Price$440
- Updated2021-12-16
- Buy
- ManufacturerMatrix Scientific
- Product number074021
- Product description5-(2-(4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl)-ethyl)-6-chloroindolin-2-one hydrochloride 95+%
- Packaging5g
- Price$280
- Updated2021-12-16
- Buy
- ManufacturerMatrix Scientific
- Product number074021
- Product description5-(2-(4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl)-ethyl)-6-chloroindolin-2-one hydrochloride 95+%
- Packaging1g
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberZ-018
- Product descriptionZiprasidone hydrochloride solution 1.0?mg/mL in methanol, certified reference material, ampule of 1?mL, Cerilliant?
- Packaging1ML
- Price$119
- Updated2022-05-15
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | H485 | Ziprasidone hydrochloride | 25mg | $38 | 2021-12-16 | Buy |
AK Scientific | X9542 | Ziprasidone hydrochloride | 1g | $48 | 2021-12-16 | Buy |
ApexBio Technology | A5350 | ZiprasidoneHCl | 10mM(in 1mL DMSO) | $60 | 2021-12-16 | Buy |
ApexBio Technology | A5350 | ZiprasidoneHCl | 100mg | $100 | 2021-12-16 | Buy |
AvaChem | 3107 | Ziprasidone Hydrochloride | 100mg | $35 | 2021-12-16 | Buy |
AvaChem | 3107 | Ziprasidone Hydrochloride | 1g | $45 | 2021-12-16 | Buy |
AvaChem | 3107 | Ziprasidone Hydrochloride | 10g | $245 | 2021-12-16 | Buy |
Crysdot | CD31004184 | Ziprasidone hydrochloride 98+% | 10g | $146 | 2021-12-16 | Buy |
DC Chemicals | DCAPI1039 | ZiprasidoneHCl >99% | 100mg | $250 | 2021-12-16 | Buy |
DC Chemicals | DCAPI1039 | ZiprasidoneHCl >99% | 1g | $1000 | 2021-12-16 | Buy |
Matrix Scientific | 074021 | 5-(2-(4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl)-ethyl)-6-chloroindolin-2-one hydrochloride 95+% | 10g | $440 | 2021-12-16 | Buy |
Matrix Scientific | 074021 | 5-(2-(4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl)-ethyl)-6-chloroindolin-2-one hydrochloride 95+% | 5g | $280 | 2021-12-16 | Buy |
Matrix Scientific | 074021 | 5-(2-(4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl)-ethyl)-6-chloroindolin-2-one hydrochloride 95+% | 1g | $96 | 2021-12-16 | Buy |
Sigma-Aldrich | Z-018 | Ziprasidone hydrochloride solution 1.0?mg/mL in methanol, certified reference material, ampule of 1?mL, Cerilliant? | 1ML | $119 | 2022-05-15 | Buy |
Properties
Melting point :>300 °C
storage temp. :Store at -20°C
solubility :Soluble in DMSO > 10 mM
form :Powder
Stability :Hygroscopic
storage temp. :Store at -20°C
solubility :Soluble in DMSO > 10 mM
form :Powder
Stability :Hygroscopic
Safety Information
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Description
Both p.o. and i.m. formulations of ziprasidone were launched in Sweden for the treatment of schizophrenia and agitated psychoses. It is the sixth marketed atypical antipsychotic after clozapine, risperidone, olanzapine, sertindole and quetiapine. The synthesis of ziprasidone involves a novel one-step process for the preparation of 3-(1- piperazinyl)-1,2-benzisothiazole followed by coupling with a chlorooxindole fragment. Ziprasidone is a very potent 5-HT2A/D2 antagonist with a ratio of about 11 in favor of the serotonin receptor. It also shows very high 5-HT2c antagonistic activity, high 5-HT1A agonistic and 5-HT1D antagonistic activity, as well as moderate antagonism of α1 and H1 receptors and moderate norepinephrine and serotonin reuptake inhibition. Its complex binding profile for serotonin and dopamine receptors resulted during clinical trials in high antipsychotic efficacy with low extrapyramidal side effects and also in antidepressive action with low propensity for weight gain in opposition to other atypical and typical neuroleptics. An intramuscular formulation of ziprasidone was demonstrated to be superior to haloperidol, a conventional neuroleptic, for the short-term treatment of agitation in acutely psychotic patients. When administered orally in the fed state, this well-tolerated agent which strongly binds to plasma proteins shows a bioavailability of about 60% which is almost 2 fold greater than in the fasted state. It is transformed into 4 circulating major metabolites by different enzyme systems. The small QTc prolongation observed with ziprasidone was found to be comparable to other antipsychotic drugs and it is considered to be without significant risk.Related product price
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