1-(1,3-BENZODIOXOL-5-YLMETHYL)-1H-INDOLE-2,3-DIONE synthesis

Yield:354781-32-1 97%

Reaction Conditions:

with potassium carbonate in acetonitrile;Heating;

Steps:

1-(benzo[d] [1,3]dioxol-5-ylmethyl)indoline-2,3-dione

General procedure: Isatin (1 mmol), corresponding benzyl bromide (1 mmol) andK2CO3 (3 mmol) were heated in acetonitrile for 1e2 h. Aftercompletion of the reaction, acetonitrile was removed on rotavoparand the product was extracted using ethyl acetate. The organic layer was dried over anhydrous Na2SO4 and concentrated. Theproduct obtained was used for next step without furtherpurification

References:

Kamal, Ahmed;Mahesh, Rasala;Nayak, V. Lakshma;Babu, Korrapati Suresh;Kumar, G. Bharath;Shaik, Anver Basha;Kapure, Jeevak Sopanrao;Alarifi, Abdullah [European Journal of Medicinal Chemistry,2016,vol. 108,art. no. 8236,p. 476 - 485]