1-(1-ADAMANTANECARBONYL)MORPHOLINE synthesis

7synthesis methods

Product Name:1-(1-ADAMANTANECARBONYL)MORPHOLINE
CAS Number:22508-50-5
Molecular formula:C15H23NO2
Molecular Weight:249.35

110-91-8 Synthesis

110-91-8
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2094-72-6 Synthesis

2094-72-6
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22508-50-5
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$134.00/50mg

Yield:-

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine in dichloromethane at 20; for 4 h;

Steps:

27 Methanone, (morphonyl) tricyclo[3.3.1.1^3,7]dec-1 -yl- (Compound C1 )

DIPEA (1 .93ml, 1 1.1 mmol) was added to a solution of Tricyclo[3.3.1.1^3,7]decane-1 - carbonyl chloride (1 ) (2g, 10.1 mmol) and morpholine; (30)(1.1 g ) in DCM (20ml) and the solution stirred at room temperature for 4 hours. The solution was washed with 0.1 N HCI (30ml), saturated NaHC0₃ (30ml), dried (Na₂S0₄), filtered and the solvents removed to give crude product which was further purified via crystallization from 15% EA in hexanes to give as a white solid.

References:

WO2014/139965,2014,A1 Location in patent:Page/Page column 36

110-91-8 Synthesis

110-91-8
691 suppliers
$9.00/1g

201230-82-2 Synthesis