[1,1'-BIPHENYL]-2-CARBONYL CHLORIDE- synthesis

11synthesis methods

Product Name:[1,1'-BIPHENYL]-2-CARBONYL CHLORIDE-
CAS Number:14002-52-9
Molecular formula:C13H9ClO
Molecular Weight:216.66

947-84-2 Synthesis

947-84-2
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14002-52-9
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$88.35/250mgs:

Yield:14002-52-9 100%

Reaction Conditions:

with oxalyl dichloride;N,N-dimethyl-formamide in toluene at 5 - 20;

Steps:

B.1.2

2-phenylbenzoic acid (4) (CAS N°947-84-2) (30 g, 151 mmol, 1.0 equiv) was suspended in toluene (200 ml) . The suspension was cooled to T5°C before adding DMF (0.2 ml) . The mixture was stirred for 10 min at T5°C before (C0C1)SUB2/SUB (14.3 ml, 166 mmol, 1.1 equiv) was added dropwise. During the addition gas evolved. The mixture was stirred at RT (overnight) . The crude mixture containing biphenyl-2-carbonyl chloride (5) (Yield: 35 g (yellow oil) , quantitative) was concentrated and used as such for the next step.

References:

WO2011/36204,2011,A1 Location in patent:Page/Page column 39-40