1,1-diphenylpropan-1-ol synthesis

14synthesis methods

Product Name:1,1-diphenylpropan-1-ol
CAS Number:5180-33-6
Molecular formula:C15H16O
Molecular Weight:212.29

100-58-3
185 suppliers
$18.00/10ml

93-55-0
7 suppliers
$15.00/25g

5180-33-6
5 suppliers
$172.00/50mg

Yield:5180-33-6 22%

Reaction Conditions:

in diethyl ether;dichloromethane at 20;Inert atmosphere;Grignard Reaction;

Steps:

2. Control Reactions for Al(OTf)3 Enhanced Grignard Reaction

General procedure: A solution of carbonyl compound in dry DCM (2 - 5 mL) and the Grignard reagent in diethylether (3.0 M, 2.0 eq.) was stirred under Ar at rt. with the reaction time the same as to achievethe completion of the corresponding Al(OTf)3-enhanced reaction. The reaction mixture was neutralized with aq. NH4Cl solution and the product extracted into EtOAc (3 x 50 mL). The organic layer was dried over Na2SO4, filtered and evaporated under reduced pressure.Purification was done via PLC

References:

Pieterse, Tanya;Visser, Melanie;Marais, Charlene;Bezuidenhoudt, Barend C. B. [Synlett,2016,vol. 27,# 10,art. no. ST-2015-D0886-L,p. 1541 - 1546] Location in patent:supporting information

119-61-9 Synthesis