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1-(1H-indazol-5-yl)thiourea synthesis

3synthesis methods
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Yield:381211-81-0 85%

Reaction Conditions:

Stage #1: 1H-indazol-5-ylamine;1,1'-Thiocarbonyldiimidazole in dichloromethane at 20; for 3 h;
Stage #2: with ammonia;water in dichloromethane at 20;

References:

Kang, Iou-Jiun;Wang, Li-Wen;Yeh, Teng-Kuang;Lee, Chung-Chi;Lee, Yen-Chun;Hsu, Sheng-Ju;Wu, Yen-Shian;Wang, Jing-Chyi;Chao, Yu-Sheng;Yueh, Andrew;Chern, Jyh-Haur [Bioorganic and Medicinal Chemistry,2010,vol. 18,# 17,p. 6414 - 6421] Location in patent:experimental part