1-(1H-INDOL-3-YL)-ETHYLAMINE synthesis

Yield:19955-83-0 20 %Spectr.

Reaction Conditions:

with [pentamethylcyclopentadienyl*Ir(N-phenyl-2-pyridinecarboxamidate)Cl];ammonium formate in d⁽⁴⁾-methanol at 37; for 15 h;chemoselective reaction;

Steps:

General Procedure for Reductive Amination of Carbonyls - NMR Quantification
General procedure: A carbonyl compound (0.2 mmol), 1,3,5-trimethoxybenzene (0.1 mmol, internal standard) andIr1 (2 μmol, 1 molpercent) were added to a 1.5-dram vial equipped with a magnetic stir bar inCD3OD (0.5 mL). Solid HCOONH4 (2 mmol, 10 equiv.) was added to the vial and the solutionwas stirred at 37 °C for 15 h. The crude reaction mixture was analyzed by 1H NMR spectroscopyusing 1,3,5-trimethoxybenzene as an internal standard (IS) for peak integrations. Each reactionwas performed in triplicate and the average yield was calculated.

References:

Nguyen, Dat P.;Sladek, Rudolph N.;Do, Loi H. [Tetrahedron Letters,2020,vol. 61,# 32,art. no. 152196] Location in patent:supporting information

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